Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Cytochemical Identification of Monocytes and Granulocytes

1971 • 2,735 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

Death in Embryonic Systems

1966 • 943 citations

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

Positive Selection of Thymocytes

1995 • 604 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4

1996 • 572 citations

The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems

1977 • 563 citations

Cell death during differentiation of the retina in the mouse

1984 • 531 citations

Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

1991 • 512 citations

CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM

1968 • 441 citations

Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers.

1983 • 412 citations

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.

1994 • 407 citations

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.

1983 • 386 citations

Macrophages are required for cell death and tissue remodeling in the developing mouse eye

1993 • 355 citations

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

1996 • 348 citations

PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony- stimulating factor receptor promoter in myeloid cells

1996 • 341 citations

Hemopoietic stem cell differentiation

1980 • 333 citations

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter.

1993 • 315 citations

Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes

1990 • 308 citations

A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex

1996 • 307 citations

PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene

1995 • 287 citations

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

1993 • 278 citations

Macrophage recruitment during limb development and wound healing in the embryonic and foetal mouse

1994 • 274 citations

Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody.

1989 • 252 citations

Mid-gestational lethality in mice lacking keratin 8.

1993 • 247 citations

Transcription Factors and Hematopoietic Development

1995 • 236 citations

The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.

1993 • 212 citations

Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1

1993 • 211 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

Gene regulation by Ets proteins

1993 • 199 citations

Differential surface expression of cell adhesion molecules during granulocyte maturation

1993 • 188 citations

Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80

1991 • 188 citations

Apoptosis during macrophage-dependent ocular tissue remodelling

1994 • 166 citations

T-cell lineage commitment and cytokine responses of thymic progenitors

1995 • 164 citations

Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis.

1993 • 152 citations

Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.

1994 • 151 citations

Early B‐Cell Development in the Mouse: Insights from Mutations Introduced by Gene Targeting

1994 • 142 citations

ULTRASTRUCTURAL CHANGES IN REGRESSING TAIL MUSCLES OF XENOPUS LARVAE AT METAMORPHOSIS

1964 • 134 citations

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

1994 • 127 citations

Embryonic Origin of the Mouse Macrophage

1972 • 124 citations

PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer.

1994 • 123 citations

What defines a pluripotent hematopoietic stem cell (PHSC): will the real PHSC please stand up! [editorial]

1994 • 121 citations

Spi-1/PU.1: an oncogene of the Ets family

1994 • 115 citations

Cell proliferation and differentiation in the fetal and early postnatal mouse thymus.

1989 • 104 citations

CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.

1995 • 103 citations

Activation of Transcription by PU.1 Requires both Acidic and Glutamine Domains

1996 • 93 citations

Frequency of VH81x usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression.

1996 • 80 citations

Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates

1996 • 79 citations

Hematopoietic lineage commitment: Role of transcription factors

1995 • 75 citations

Lymphocyte Ontogeny and Activation in Gene Targeted Mutant Mice

1994 • 64 citations

Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells.

1993 • 61 citations

Identification of erythropoietin producing cells in fetal mouse liver cultures.

1977 • 54 citations

Mouse β-Globin DNA-Binding Protein B1 is Identical to a Proto-Oncogene, the Transcription Factor Spi-1/PU.1, and is Restricted in Expression to Hematopoietic Cells and the Testis

1993 • 45 citations

Inversions Produced during V(D)J Rearrangement at IgH, the Immunoglobulin Heavy-Chain Locus

1995 • 37 citations

Hematopoietic stem cells: concepts, assays, and controversies.

1991 • 20 citations