Development in the thymus: it takes two to tango

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

The thymic microenvironment

1993 • 459 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Morphogenetic interactions in the development of the mouse thymus gland

1960 • 336 citations

The Developmental Biology of T Lymphocytes

1988 • 300 citations

TISSUE INTERACTION IN THE DEVELOPMENT OF THYMUS LYMPHOCYTES

1969 • 295 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

CD40 is functionally expressed on human thymic epithelial cells.

1992 • 261 citations

T-Cell Differentiation is Influenced by Thymic Microenvironments

1991 • 239 citations

A possible mammary stem cell line

1978 • 230 citations

Towards an integrated view of thymopoiesis

1991 • 205 citations

Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations

1985 • 199 citations

Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment

1991 • 190 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Heterogeneity of epithelial cells in the human thymus

1984 • 164 citations

Cytokines in T-cell development

1991 • 164 citations

Control of lens epithelial cell survival.

1993 • 161 citations

Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens

1984 • 138 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

Lymphatic Tissues and in Vivo Immune Responses

1991 • 129 citations

Growth of epithelial cells in the thymic medulla is under the control of mature T cells.

1992 • 128 citations

The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies.

1985 • 124 citations

Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?

1987 • 117 citations

The human thymus microenvironment: in vivo identification of thymic nurse cells and other antigenically-distinct subpopulations of epithelial cells.

1981 • 116 citations

Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor.

1990 • 116 citations

Interferon-gamma modulates HLA class II antigen expression on cultured human thymic epithelial cells.

1985 • 110 citations

Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level.

1991 • 109 citations

Stromal cell types in the developing thymus of the normal and nude mouse embryo

1985 • 108 citations

The phenotypic heterogeneity of mouse thymic stromal cells.

1990 • 104 citations

T-cell differentiation in thymus organ cultures.

1990 • 100 citations

The Developmental Biology Of T Lymphocytes

1988 • 98 citations

Functional histology of the human thymus

1991 • 93 citations

IL-1, IL-4, and IFN-gamma differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells.

1991 • 87 citations

The functional capabilities of cells leaving the thymus.

1984 • 84 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

Human intrathymic T cell differentiation.

1990 • 78 citations

Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.

1992 • 72 citations

Thymic epithelial antibodies: immunohistological analysis and introduction of nomenclature.

1989 • 66 citations

Molecular interactions between stromal cells and B lymphocyte precursors.

1991 • 63 citations

Immunosuppression with cyclosporin A alters the thymic microenvironment.

1989 • 56 citations

Human thymic epithelial cells produce interleukin-3

1991 • 55 citations

Complex lymphoid and epithelial thymic tumours in Thyl-myc transgenic mice

1989 • 54 citations

Cyclosporin and the rat thymus. An immunohistochemical study.

1990 • 54 citations

Thymic shared antigen-1. A novel thymocyte marker discriminating immature from mature thymocyte subsets.

1992 • 53 citations

The cytokine wall chart

1993 • 51 citations

Human thymic epithelium and T cell development: current issues and future directions.

1990 • 48 citations

Alterations in the cortical thymic epithelium of rats after in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): An (immuno)histological study

1992 • 44 citations

Phenotypic characterization of murine thymic microenvironments.

1990 • 43 citations

Thymic pathology in primary and secondary immunodeficiencies

1992 • 41 citations

Synergistic induction of interleukin-6 production and gene expression in human thymic epithelial cells by LPS and cytokines

1991 • 38 citations

Phenotypic Characterization of Chicken Bursal Stromal Elements

1990 • 37 citations

Implantation of cultured thymic fragments in congenitally athymic (nude) rats

1988 • 34 citations

Human Thy-1 antigen: cell surface expression on early T and B lymphocytes.

1983 • 32 citations

A novel cytokine-responsive cell surface glycoprotein defines a subset of medullary thymic epithelium in situ.

1993 • 32 citations

Functional evidence for a monoclonal antibody that binds to the human IL-4 receptor.

1988 • 30 citations

Rat thymic epithelial cells in culture constitutively secrete IL-1 and IL-6

1991 • 28 citations

Antibodies against the T cell receptor/CD3 complex interfere with distinct intra-thymic cell-cell interactionsin vivo: correlation with arrest of T cell differentiation

1989 • 28 citations

The true function of the thymus?

1988 • 26 citations

Phenotypic Characterization of Chicken Thymic Stromal Elements

1992 • 25 citations

T cell activation by mycobacterial antigens in inflammatory synovitis

1991 • 25 citations

A novel T-lymphocyte molecule that may function in the induction of self-tolerance and MHC-restriction within the human thymic microenvironment.

1988 • 23 citations

Analysis of the fine distribution of thymic epithelial microenvironmental molecules by immuno-electron microscopy.

1989 • 23 citations

Human thymic dendritic cell‐thymocyte association: ultrastructural cell phenotype analysis

1989 • 22 citations

Immunohistology of T cell differentiation in the thymus of H‐Y‐specific T cell receptor α/β transgenic mice

1990 • 21 citations

Expression of a T cell receptor gamma-chain (V gamma 1.1J gamma 4C gamma 4) transgene in mice influences T cell receptor ontogeny and thymic architecture during development.

1990 • 20 citations

Pathology of the Thymus in Immunodeficiency States

1986 • 19 citations

A Novel Adhesion Molecule in the Murine Thymic Microenvironment: Functional and Biochemical Analysis

1992 • 18 citations

Human Thymic Epithelial Cells in Serum-Free Culture: Nature and Effects on Thymocyte Cell Lines

1992 • 17 citations

Tyrosine kinase activation in thymic epithelial cells: necessity of thymocyte contact through the gp23/45/90 adhesion complex

1992 • 17 citations

The intrathymic microenvironment: expression of lectin receptors and lectin-like molecules of differentiation antigens and MHC gene products.

1983 • 16 citations

Five novel antigens illustrate shared phenotype between mouse thymic stromal cells, thymocytes, and peripheral lymphocytes

1992 • 14 citations

Thymic hyperplasia in transgenic mice caused by immortal epithelial cells expressing c‐kit ligand

1992 • 14 citations

Unravelling the complexity of intrathymic cell‐cell interactions

1988 • 13 citations

Phenotypic Analysis of the Chicken Thymic Microenvironment During Ontogenic Development

1992 • 12 citations

Surface expression of CD4 and Thy-1 on mouse thymic stromal cells

1990 • 11 citations

Interferon Gamma Alters the Phenotype of Rat Thymic Epithelial Cells in Culture and Increases Interleukin-6 Production

1992 • 11 citations

Control of helper-T-cell proliferation by recognition of la and Mac-1 antigens on phagocytic cells of the thymic reticulum

1988 • 8 citations

Selective stimulation of thymocyte precursors mediated by specific cytokines. Different CD3+ subsets are generated by IL-1 versus IL-2.

1991 • 7 citations

The Effect of Graded Doses of Fission Neutrons or X Rays on the Stromal Compartment of the Thymus in Mice

1988 • 5 citations

Antigens shared by thymic stromal cells and T lymphocytes are abnormally expressed in AKR thymuses.

1989 • 3 citations

Microexplants of human thymus: how do the thymic epithelial cells react to lymphocyte death?

1990 • 1 citations