Fyn Can Partially Substitute for Lck in T Lymphocyte Development

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Positive Selection of Thymocytes

1995 • 604 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Activation events during thymic selection.

1992 • 326 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

1996 • 286 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

1992 • 212 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes.

1994 • 180 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

1993 • 156 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

1992 • 147 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

1993 • 130 citations

Inhibition of T Cell Receptor Expression and Function in Immature CD4 ⁺ cD8 ⁺ Cells by CD4

1990 • 129 citations

Developmental regulation of lck gene expression in T lymphocytes.

1991 • 124 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 • 98 citations

Selection is not required to produce invariant T-cell receptor γ-gene junctional sequences

1993 • 94 citations

Receptors and signals in early thymic selection

1995 • 90 citations

Participation of CD4 coreceptor molecules in T-cell repertoire selection

1991 • 85 citations

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes

1988 • 84 citations

TCR Activation of ZAP70 Is Impaired in CD4+CD8+ Thymocytes as a Consequence of Intrathymic Interactions that Diminish Available p56lck

1996 • 83 citations

A signaling pathway governing early thymocyte maturation

1995 • 76 citations

Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development

1994 • 75 citations

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.

1996 • 74 citations

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway.

1995 • 74 citations

Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection.

1991 • 72 citations

Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines.

1995 • 72 citations

Activation of src family kinases in human pre-B cells by IL-7.

1994 • 71 citations

Requirement for Tyrosine Kinase p56^lckfor Thymic Development of Transgenic γδ T Cells

1993 • 71 citations

Requirement for Positive Selection of γδ Receptor-Bearing T Cells

1991 • 69 citations

Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection

1995 • 68 citations

TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.

1997 • 62 citations

Changes in the relative abundance of type I and type II lck mRNA transcripts suggest differential promoter usage during T-cell development.

1990 • 62 citations

In vitro maturation of clonal CD4+CD8+ cell lines in response to TCR engagement.

1995 • 59 citations

Disruption of CD8‐dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1992 • 57 citations

Positive selection of CD4+ and CD8+ T cells

1996 • 55 citations

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1995 • 52 citations

Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice.

1995 • 45 citations

Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.

1991 • 31 citations

CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.

1991 • 30 citations

Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.

1993 • 23 citations

Tyrosine kinase triggering in thymocytes undergoing positive selection

1992 • 15 citations

T-Cell development and selection in the intestinal epithelium

1995 • 14 citations

Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection.

1992 • 12 citations

Lck dependence of signaling pathways activated by γirradiation and CD3ε engagement in RAG-1^-/-immature thymocytes

1996 • 11 citations

Sequential Occurrence of Positive and Negative Selection during T Lymphocyte Maturation

1993 • 5 citations