The Steel factor

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1988 • 727 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.

1990 • 599 citations

Requirement for mast cell growth factor for primordial germ cell survival in culture

1991 • 482 citations

In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development.

1991 • 479 citations

Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture

1991 • 459 citations

Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

1991 • 424 citations

Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism.

1991 • 385 citations

Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice.

1987 • 380 citations

Decreased production of mast cells in S1/S1d anemic mice

1979 • 372 citations

Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators

1991 • 369 citations

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.

1991 • 346 citations

The Cellular Basis of the Genetically Determined Hemopoietic Defect in Anemic Mice of Genotype Sl/Sld

1965 • 345 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

The Dominant W ⁴² Spotting Phenotype Results from a Missense Mutation in the c- kit Receptor Kinase

1990 • 287 citations

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.

1991 • 265 citations

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

1991 • 264 citations

bFGF is the putative natural growth factor for human melanocytes

1987 • 259 citations

The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.

1991 • 222 citations

Permissive role of interleukin 3 (IL‐3) in proliferation and differentiation of multipotential hemopoietic progenitors in culture

1985 • 214 citations

Deletion of the c-kit protooncogene in the human developmental defect piebald trait.

1991 • 212 citations

The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor

1991 • 169 citations

c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas.

1992 • 167 citations

The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells.

1991 • 157 citations

Tissue transplantation as an analytic and therapeutic tool in hereditary anemias

1970 • 145 citations

Effect of c-kit ligand on in vitro human megakaryocytopoiesis

1991 • 140 citations

Human burst-forming units-erythroid need direct interaction with stem cell factor for further development

1991 • 138 citations

Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates

1991 • 133 citations

Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells.

1991 • 106 citations

STEEL, A NEW DOMINANT GENE IN THE HOUSE MOUSE

1956 • 102 citations

Steel factor is required for maintenance, but not differentiation, of melanocyte precursors in the neural crest

1992 • 95 citations

A comparison of pigment cell development in albino, steel, and dominant-spotting mutant mouse embryos

1970 • 91 citations

In vitro growth and regulation of bone marrow enriched CD34+ hematopoietic progenitors in Diamond-Blackfan anemia

1991 • 88 citations

Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24.

1991 • 84 citations

Amino acid sequence and post-translational modification of stem cell factor isolated from buffalo rat liver cell-conditioned medium

1991 • 80 citations

Diamond-blackfan anemia: in vitro response of erythroid progenitors to the ligand for c-kit

1991 • 77 citations

Proof of whole-cell implant in therapy of W-series anemia

1968 • 70 citations

Diamond-Blackfan anemia: heterogenous response of hematopoietic progenitor cells in vitro to the protein product of the steel locus

1991 • 70 citations

Stem cell factor in combination with granulocyte colony-stimulating factor (CSF) or granulocyte-macrophage CSF synergistically increases granulopoiesis in vivo

1991 • 67 citations

Influence of steel factor on hemoglobin synthesis in sickle cell disease

1992 • 41 citations

Effect of mast cell growth factor (c-kit ligand) on clonogenic leukemic precursor cells

1992 • 39 citations

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

1991 • 36 citations

Influence of steel factor on hemoglobin synthesis in sickle cell disease

1992 • 5 citations