The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Cellular and developmental properties of fetal hematopoietic stem cells

1990 • 317 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

1994 • 218 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations

1985 • 199 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1995 • 163 citations

The regulation and function of p21ras during T-cell activation and growth

1995 • 160 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

1993 • 130 citations

T-cell differentiation in thymus organ cultures.

1990 • 100 citations

Genetics of signal transduction in invertebrates

1994 • 96 citations

Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development

1994 • 75 citations

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway.

1995 • 74 citations

Regulation of T cell receptor (TCR)‐β locus allelic exclusion and initiation of TCR‐α locus rearrangement in immature thymocytes by signaling through the CD3 complex

1995 • 73 citations

Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro.

1991 • 70 citations

Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors.

1994 • 70 citations

Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein kinase in astrocytes

1993 • 68 citations

Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate

1993 • 59 citations

Double-negative thymocyte subsets in CD3′ chain-deficient mice: Absence of HSA+CD44−CD25− cells

1994 • 53 citations

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1995 • 52 citations

Signal transduction and cell fate specification during Caenorhabditis elegans vulval development

1994 • 51 citations

T cell differentiation: control by the pre-TCR and αβ TCR

1995 • 5 citations