Regulation of Recombination Activating Gene Expression During Lymphocyte Development

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development

1983 • 490 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

B lymphocytes may escape tolerance by revising their antigen receptors.

1993 • 425 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the J_H locus

1993 • 404 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

1995 • 363 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

1991 • 335 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

1987 • 306 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

Initiation of V(D)J recombination in a cell-free system

1995 • 286 citations

IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development

1994 • 284 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

A subpopulation of B220+ cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors.

1996 • 236 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

Positive and negative selection events during B lymphopoiesis

1995 • 195 citations

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

1994 • 189 citations

The status of Ig loci rearrangements in single cells from different stages of B cell development

1995 • 186 citations

Cell cycle regulation of V(D)J recombination-activating protein RAG-2.

1994 • 184 citations

Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts

1988 • 177 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa.

1993 • 160 citations

A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines.

1993 • 141 citations

Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice

1993 • 138 citations

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.

1993 • 135 citations

An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement.

1994 • 134 citations

Abnormalities of the Immune System Induced by Dysregulated bcl-2 Expression in Transgenic Mice

1990 • 129 citations

Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface

1995 • 116 citations

A role for a pre-T-cell receptor in T-cell development

1993 • 114 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

B cell development in mice with a defective λ₅ gene

1993 • 104 citations

Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.

1992 • 90 citations

Generation and regeneration of cells of the B-lymphocyte lineage

1993 • 89 citations

The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes.

1994 • 81 citations

γδ T-cell development

1993 • 61 citations

Function and Control of Recombination‐Activating Gene Activity^a

1992 • 58 citations

Regulation of gene expression at early stages of B-cell differentiation

1994 • 58 citations

Development of αβ T cells

1993 • 56 citations

IL-2 receptor α chain expression during early B lymphocyte differentiation

1994 • 50 citations

Transcriptional control points during lymphopoiesis

1994 • 40 citations

Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis.

1987 • 38 citations

Induction of sterile transcription from the kL chain gene locus in V(D)J recombinasedeficient progenitor B cells

1995 • 35 citations

Expression of the V(D)J recombinase gene RAG-1 is tightly regulated and involves both transcriptional and post-transcriptional controls

1992 • 24 citations

B-cell development in mouse and man

1995 • 16 citations

Comparison of RAG gene expression in normal and transformed precursor lymphocytes

1993 • 15 citations

Control of VDJ Recombinase Activity

1989 • 14 citations