Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus.

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Handbook of Experimental Immunology.

1968 • 2,480 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Handbook of experimental immunology

1987 • 680 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

1994 • 238 citations

Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation

1993 • 209 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.

1986 • 145 citations

Production of Homozygous Mutant ES Cells with a Single Targeting Construct

1992 • 140 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

Cellular aspects of early T-cell development

1992 • 91 citations

CD2ϵ and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function

1995 • 85 citations

Methods for cloning and analysis of eukaryotic genes

1990 • 71 citations