Early T‐cell Development in CD3‐deficient Mice

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Control points in early T-cell development

1993 • 429 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

The generation and fate of thymocytes.

1990 • 309 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

Regulation of TCR α and β gene allelic exclusion during T-cell development

1992 • 284 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

Crystal Structure of the β Chain of a T Cell Antigen Receptor

1995 • 267 citations

Bclx regulates the survival of double-positive thymocytes.

1995 • 249 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

1994 • 233 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

1995 • 180 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

Role of TCR ζ Chain in T Cell Development and Selection

1994 • 141 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

α β and γ δ T cells can share a late common precursor

1995 • 139 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

Requirement for TNF-α and IL-1α in Fetal Thymocyte Commitment and Differentiation

1995 • 135 citations

Cytokine production and requirements during T-cell development

1995 • 104 citations

V(D)J recombination and the cell cycle

1995 • 98 citations

Activation-Driven Programmed Cell Death and T Cell Receptor ζη Expression

1989 • 98 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro

1995 • 95 citations

Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins.

1991 • 82 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

A signaling pathway governing early thymocyte maturation

1995 • 76 citations

Evidence for a single-niche model of positive selection.

1994 • 76 citations

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway.

1995 • 74 citations

Regulation of T cell receptor (TCR)‐β locus allelic exclusion and initiation of TCR‐α locus rearrangement in immature thymocytes by signaling through the CD3 complex

1995 • 73 citations

Expression of genes encoding the pre-TCR and CD3 complex during thymus development

1995 • 71 citations

Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection

1995 • 68 citations

Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.

1994 • 64 citations

Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice.

1994 • 62 citations

Regulation of thymocyte development through CD3. II. Expression of T cell receptor beta CD3 epsilon and maturation to the CD4+8+ stage are highly correlated in individual thymocytes.

1993 • 61 citations

Two Pathways of B‐Lymphocyte Development in Mouse Bone Marrow and the Roles of Surrogate L Chain in this Development

1994 • 57 citations

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase

1994 • 54 citations

Double-negative thymocyte subsets in CD3′ chain-deficient mice: Absence of HSA+CD44−CD25− cells

1994 • 53 citations

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1995 • 52 citations

Over-expression of CD3ε transgenes blocks T lymphocyte development

1995 • 51 citations

Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells.

1993 • 50 citations

Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.

1994 • 37 citations

_γδ T cells promote CD4 and CD8 expression by SCID thymocytes

1993 • 35 citations

Immature thymocytes become sensitive to calcium-mediated apoptosis with the onset of CD8, CD4, and the T cell receptor expression: a role for bcl-2?

1993 • 34 citations

Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.

1994 • 34 citations

Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point.

1993 • 32 citations

Normal development and function of natural killer cells in CD3 epsilon delta 5/delta 5 mutant mice.

1995 • 30 citations

Nuclear factors that mediate intrathymic signals are developmentally regulated.

1994 • 27 citations