Syk tyrosine kinase required for mouse viability and B-cell development

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

1985 • 599 citations

Gene Targeting: A Practical Approach

1994 • 592 citations

Gene targeting: a practical approach.

1993 • 585 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

1994 • 495 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Syk Protein-tyrosine Kinase Is Regulated by Tyrosine-phosphorylated Iga/Ig/3 Immunoreceptor Tyrosine Activation Motif Binding and Autophosphorylation

1995 • 270 citations

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

1994 • 248 citations

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3.

1994 • 227 citations

B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames

1991 • 203 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

1994 • 189 citations

The Role of Igβ in Precursor B Cell Transition and Allelic Exclusion

1995 • 133 citations

Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets.

1993 • 127 citations

Transmembrane signaling by antigen receptors of B and T lymphocytes

1995 • 109 citations

The expression of the Ig H chain repertoire in developing bone marrow B lineage cells.

1991 • 95 citations

The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

1991 • 77 citations

Developmentally controlled selection of antibody genes: Characterization of individual V_H7183 genes and evidence for stage‐specific somatic diversification

1992 • 64 citations

Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling

1994 • 64 citations

Influence of surrogate L chain on D_HJ_H-reading frame 2 suppression in mouse precursor B cells

1994 • 31 citations

Sequences of four new members of the V H7183 gene family in BALB/c mice

1994 • 21 citations