Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Selective Events in T Cell Development

1994 • 486 citations

Control points in early T-cell development

1993 • 429 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting.

1991 • 125 citations

Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.

1988 • 84 citations

Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins.

1991 • 82 citations

T-cell receptor δ-chain can substitute for α to form a βδ heterodimer

1989 • 68 citations

Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.

1987 • 58 citations

Associations between subunit ectodomains promote T cell antigen receptor assembly and protect against degradation in the ER

1993 • 46 citations

T-cell antigen receptor (TCR)-α/β heterodimer formation is a prerequisite for association of CD3-ζ2 into functionally competent TCR·CD3 complexes

1989 • 43 citations

CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

1992 • 37 citations

Surface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post‐endoplasmic reticulum compartment

1989 • 37 citations

Genetic reconstitution of the T cell receptor (TcR) α/β heterodimer restores the association of CD3 ζ₂ with the TcR/CD3 complex

1991 • 10 citations

Dismantling the immune system

1993 • 4 citations