Genetic analyses of integrin function in mice

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 • 792 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Consequences of lack of beta 1 integrin gene expression in mice.

1995 • 724 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

1995 • 601 citations

Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.

1995 • 593 citations

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

1996 • 558 citations

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice

1995 • 554 citations

Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice

1996 • 539 citations

Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

1985 • 518 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

1996 • 402 citations

Constitutive activation of Src family kinases in mouse embryos that lack Csk

1993 • 401 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation.

1995 • 393 citations

Integrin β4 mutations associated with junctional epidermolysis bullosa with pyloric atresia

1995 • 389 citations

Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix

1995 • 349 citations

Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins

1996 • 348 citations

Differential Requirements for α4 Integrins during Fetal and Adult Hematopoiesis

1996 • 347 citations

Developmental regulation of integrin expression at the time of implantation in the mouse embryo

1993 • 321 citations

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

1996 • 312 citations

Beta 1 integrin-dependent and -independent polymerization of fibronectin.

1996 • 292 citations

Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells

1985 • 272 citations

Mouse embryonic hematopoiesis

1995 • 266 citations

Deletion of Integrin α1 by Homologous Recombination Permits Normal Murine Development but Gives Rise to a Specific Deficit in Cell Adhesion

1996 • 263 citations

Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts.

1995 • 254 citations

Gene targeting yields a CD18-mutant mouse for study of inflammation.

1993 • 240 citations

Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK.

1995 • 218 citations

The T genes in embryogenesis

1994 • 215 citations

Neural crest cell formation and migration in the developing embryo

1994 • 189 citations

Antibodies against domain E3 of laminin-1 and integrin alpha 6 subunit perturb branching epithelial morphogenesis of submandibular gland, but by different modes.

1995 • 177 citations

Cell Migration in the Vertebrate Embryo: Role of Cell Adhesion and Tissue Environment in Pattern Formation

1985 • 174 citations

Mesodermal development in mouse embryos mutant for fibronectin

1996 • 170 citations

Assembly of extracellular matrix

1992 • 159 citations

Retrovirally introduced antisense integrin RNA inhibits neuroblast migration in vivo

1992 • 151 citations

Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles.

1996 • 127 citations

Targeted deletion of beta 1 integrins in F9 embryonal carcinoma cells affects morphological differentiation but not tissue-specific gene expression.

1993 • 73 citations