The V–J Recombination of T Cell Receptor-γ Genes Is Blocked in Interleukin-7 Receptor–deficient Mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Gamma/Delta Cells

1993 • 819 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

1995 • 376 citations

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1993 • 345 citations

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

1996 • 316 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

Genomic organization of the genes encoding mouse T-cell receptor α-chain

1985 • 202 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

Lymphocyte Development from Stem Cells

1992 • 170 citations

Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus.

1989 • 162 citations

Gamma/Delta T Cells

1993 • 146 citations

Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

1995 • 127 citations

Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice.

1993 • 126 citations

T cell receptor-gamma and -delta genes preferentially utilized by adult thymocytes for the surface expression.

1989 • 110 citations

V(D)J recombination and the cell cycle

1995 • 98 citations

T-cell gamma gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets.

1987 • 75 citations

Interleukin 7-induced expression of specific T cell receptor gamma variable region genes in murine fetal liver cultures.

1993 • 69 citations

Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells

1986 • 55 citations

Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells.

1996 • 53 citations

Organization of the Murine T-Cell Receptor γ Locus

1993 • 35 citations

Interleukin 7 preferentially supports the growth of γδ T cell receptor-bearing T cells from fetal thymocytes in vitro

1991 • 35 citations

Expression and rearrangement of the alpha, beta, and gamma chain genes of the T cell receptor in cloned murine large granular lymphocyte lines. No correlation with the cytotoxic spectrum.

1986 • 27 citations

Bone marrow clones representing an intermediate stage of development between hematopoietic stem cells and pro-T-lymphocyte or pro-B- lymphocyte progenitors

1993 • 19 citations