Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Tumor suppressor genes

1991 • 775 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

p53 and DNA polymerase α compete for binding to SV40 T antigen

1987 • 291 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Pathology of Laboratory Animals

1978 • 266 citations

A monoclonal antibody that recognizes B cells and B cell precursors in mice.

1981 • 260 citations

p53 transformation-related protein: Detection by monoclonal antibody in mouse and human cells

1981 • 222 citations

Mouse p53 inhibits SV40 origin-dependent DNA replication

1987 • 216 citations

A New Inbred Subline of Mice (129/terSv) with a High Incidence of Spontaneous Congenital Testicular Teratomas2

1973 • 198 citations

Analysis of the gene coding for the murine cellular tumour antigen p53.

1984 • 182 citations

The cellular oncogene p53 can be activated by mutagenesis

1985 • 181 citations

Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells.

1990 • 170 citations

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

1990 • 156 citations

Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus.

1988 • 131 citations

Mortality, Major Cause of Moribundity, and Spontaneous Tumors in CD-1 Mice

1988 • 131 citations

Inactivation of p53 gene expression by an insertion of Moloney murine leukemia virus-like DNA sequences.

1984 • 106 citations

Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene.

1989 • 97 citations

Pathology of laboratory animals

1979 • 85 citations

Structural comparisons of wild-type and nuclear transport-defective simian virus 40 large tumor antigens

1984 • 31 citations

Ovarian Choriocarcinoma in the Mouse

1987 • 23 citations