Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

PCR protocols — A guide to methods and applications

1990 • 10,078 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Handbook of Experimental Immunology.

1968 • 2,480 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Teratocarcinomas and embryonic stem cells: A practical approach

1987 • 768 citations

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells.

1977 • 740 citations

Handbook of experimental immunology

1987 • 680 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Long-term culture of B lymphocytes and their precursors from murine bone marrow.

1982 • 612 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

Clonal and systemic analysis of long-term hematopoiesis in the mouse.

1990 • 577 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells

1992 • 520 citations

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

1994 • 459 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Clonal analysis of hematopoietic stem-cell differentiation in vivo.

1991 • 379 citations

Transient nature of early haematopoietic spleen colonies

1982 • 377 citations

Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells

1993 • 345 citations

Isolation of murine pluripotent hemopoietic stem cells.

1984 • 333 citations

Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule

1991 • 331 citations

Cellular and developmental properties of fetal hematopoietic stem cells

1990 • 317 citations

Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family.

1991 • 300 citations

Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

1993 • 288 citations

Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages

1992 • 231 citations

Growth and Differentiation in the Hemopoietic System

1987 • 220 citations

Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell.

1989 • 209 citations

Structure-function studies of a colony stimulating factor (CSF-1).

1982 • 175 citations

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells.

1993 • 174 citations

Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells

1994 • 153 citations

PRODUCTION OF SINGLE-STRANDED DNA BY ASYMMETRIC PCR

1990 • 127 citations

Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis

1992 • 120 citations

The c‐kit‐encoded tyrosine kinase regulates the proliferation of early pre‐B cells

1991 • 113 citations

Clonal nature of mast-cell clusters formed in W/Wv mice after bone marrow transplantation

1979 • 91 citations

Potentials for lymphoid differentiation by cells from long term cultures of bone marrow.

1980 • 78 citations

In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand.

1992 • 69 citations

In vitro studies on lymphocyte differentiation. I. Long term in vitro culture of cells giving rise to functional lymphocytes in irradiated mice.

1978 • 68 citations

Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA.

1993 • 60 citations

Giant granules of beige mice. A quantitative marker for granulocytes in bone marrow transplantation.

1973 • 59 citations

Hematopoietic development of vav-/- mouse embryonic stem cells.

1994 • 49 citations

Characterization of early B lymphocyte precursors present in long-term bone marrow cultures.

1983 • 49 citations

Clonal analysis of primary marrow stroma: functional homogeneity in support of lymphoid and myeloid cell lines and identification of positive and negative regulators.

1994 • 48 citations

Developmentally regulated cell surface expression and function of c-kit receptor during lymphocyte ontogeny in the embryo and adult mice

1992 • 40 citations

Fetal Liver Pro-B and Pre-B Lymphocyte Clones: Expression of Lymphoid-Specific Genes, Surface Markers, Growth Requirements, Colonization of the Bone Marrow, and Generation of B Lymphocytes In Vivo and In Vitro

1992 • 39 citations

Processing by the thymus is not required for cells that cure and populate W/WV recipients

1979 • 36 citations

POPULATION OF LYMPHOID TISSUES IN CURED W-ANEMIC MICE BY DONOR CELLS

1976 • 36 citations

Growth And Differentiation In The Hematopoietic System

1987 • 31 citations

GIANT GRANULES OF BEIGE MICE

1973 • 30 citations

The haematopoietic stem cell and its clonal progeny: mechanisms regulating the hierarchy of primitive haematopoietic cells.

1992 • 27 citations

Fetal liver pro-B and pre-B lymphocyte clones: expression of lymphoid-specific genes, surface markers, growth requirements, colonization of the bone marrow, and generation of B lymphocytes in vivo and in vitro.

1992 • 18 citations