MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

1993 • 345 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

1993 • 333 citations

Dominant Mutations in a Gene Encoding a Putative Protein Kinase (BCKT) Bypass the Requirement for a Saccharomyces cerevisiae Protein Kinase C Homolog

1992 • 322 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

MKK1 and MKK2, Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C

1993 • 306 citations

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.

1993 • 305 citations

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.

1992 • 292 citations

PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

1993 • 289 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.

1992 • 256 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

The yeast STE12 protein binds to the DNA sequence mediating pheromone induction.

1989 • 245 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.

1992 • 234 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.

1992 • 232 citations

A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.

1991 • 231 citations

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

1993 • 217 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

1991 • 208 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro

1993 • 190 citations

A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae.

1993 • 189 citations

Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.

1992 • 188 citations

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.

1993 • 187 citations

Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog.

1992 • 181 citations

cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.

1993 • 179 citations

STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast.

1990 • 178 citations

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.

1993 • 171 citations

Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.

1993 • 166 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

Ordered phosphorylation of p42^mapk by MAP kinase kinase

1992 • 159 citations

A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.

1988 • 153 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

1993 • 150 citations

Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.

1990 • 148 citations

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

1992 • 142 citations

Erks: their fifteen minutes has arrived.

1992 • 133 citations

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

1993 • 128 citations

Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos.

1993 • 120 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

1993 • 73 citations

Complementation of byrl in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase

1993 • 73 citations

Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis.

1993 • 67 citations

The amino acid sequence of a mammalian MAP kinase kinase.

1992 • 66 citations

Schizosaccharomyces pombe Spk1 is a Tyrosine-Phosphorylated Protein Functionally Related to Xenopus Mitogen-Activated Protein Kinase

1993 • 57 citations

Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase.

1993 • 44 citations

Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line.

1993 • 40 citations

Isolation of two members of the rat MAP kinase kinase gene family

1993 • 29 citations