Early T Lymphocyte Progenitors

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

The Biology of Hematopoietic Stem Cells

1995 • 775 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1993 • 673 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes

1993 • 474 citations

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

1992 • 458 citations

Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire

1993 • 437 citations

Control points in early T-cell development

1993 • 429 citations

The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins.

1994 • 424 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

1992 • 368 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

1990 • 306 citations

Developmental potential of the earliest precursor cells from the adult mouse thymus.

1991 • 294 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

A population of early fetal thymocytes expressing FcγRIIIII contains precursors of T lymphocytes and natural killer cells

1992 • 264 citations

Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.

1992 • 263 citations

A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

1994 • 233 citations

Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

1993 • 233 citations

Cell kinetics in the fetal mouse thymus: precursor cell input, proliferation, and emigration.

1987 • 230 citations

Mouse hematopoietic stem cells

1991 • 224 citations

Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow

1992 • 224 citations

Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development

1989 • 222 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

Dynamics of Early T Cells: Prothymocyte Migration and Proliferation in the Adult Mouse Thymus

1986 • 188 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow

1992 • 183 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Mouse hematopoietic stem cells

1991 • 178 citations

Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells.

1991 • 173 citations

Demonstration of a cyclic renewal of the lymphocyte precursor cells in the quail thymus during embryonic and perinatal life.

1982 • 172 citations

Lymphocyte Development from Stem Cells

1992 • 170 citations

Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development.

1993 • 165 citations

Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice.

1992 • 161 citations

Murine thymocytes proliferate in direct response to interleukin-7

1989 • 157 citations

Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny.

1990 • 148 citations

α β and γ δ T cells can share a late common precursor

1995 • 139 citations

Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation

1995 • 138 citations

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

1993 • 130 citations

Extrathymic T cell differentiation

1995 • 129 citations

Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes

1987 • 112 citations

Commitment to the T cell receptor‐αβ or ‐γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes

1992 • 110 citations

Human natural killer cell committed thymocytes and their relation to the T cell lineage.

1993 • 107 citations

Separation and functional analysis of bone marrow cells separated by rhodamine-123 fluorescence.

1987 • 105 citations

Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells.

1989 • 102 citations

Thymic stem cells in mouse bone marrow

1994 • 101 citations

The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44.

1995 • 101 citations

IL-7 maintains the T cell precursor potential of CD3-CD4-CD8- thymocytes.

1991 • 100 citations

Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development

1993 • 100 citations

Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells

1991 • 92 citations

Phenotypic analysis of murine long-term hemopoietic reconstituting cells quantitated competitively in vivo and comparison with more advanced colony-forming progeny.

1995 • 90 citations

Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.

1993 • 85 citations

Interleukin 7-induced expression of specific T cell receptor gamma variable region genes in murine fetal liver cultures.

1993 • 69 citations

Early stages in human and mouse T-cell development

1994 • 63 citations

In vitro development of B cells and macrophages from early mouse fetal thymocytes

1994 • 62 citations

Human thymocyte development in mouse organ cultures

1990 • 53 citations

Mouse stem cell antigen Sca-2 is a member of the Ly-6 family of cell surface proteins.

1994 • 52 citations

Delineation of T-progenitor cell activity within the CD34+ compartment of adult bone marrow

1995 • 48 citations

The majority of immature fetal thymocytes can be induced to proliferate to IL-2 and differentiate into cells indistinguishable from mature natural killer cells.

1993 • 47 citations

The junctional modifications of a T cell receptor gamma chain are determined at the level of thymic precursors.

1991 • 45 citations

Intrathymic lymphoid precursor cells during fetal thymus development.

1993 • 43 citations

Assessment of CD4 expression by early T precursor cells and by dendritic cells in the human thymus.

1994 • 39 citations

Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase.

1995 • 35 citations

Phenotypic analysis of the early events during repopulation of the thymus by the bone marrow prothymocyte

1990 • 35 citations

Identification and characterization of pro-T lymphocytes and lineage-uncommitted lymphocyte precursors from mice with three novel surface markers.

1990 • 34 citations

CD4dull+ hematopoietic progenitor cells in murine bone marrow

1993 • 31 citations

Developmental regulation of the intrathymic T cell precursor population.

1991 • 30 citations

Development of γδ T cells in the adult murine thymus

1993 • 30 citations

Demonstration that Thy(lo) subsets of mouse bone marrow that express high levels of lineage markers are not significant hematopoietic progenitors

1994 • 30 citations

Pro‐T cells in fetal thymus express c‐kit and RAG‐2 but do not rearrange the gene encoding the T cell receptor β chain

1994 • 26 citations

A lymphostromal molecule, thymic shared Ag-1, regulates early thymocyte development in fetal thymus organ culture.

1993 • 22 citations

ER-MP12 antigen, a new cell surface marker on mouse bone marrow cells with thymus-repopulating ability: I. Intrathymic repopulating ability of ER-MP12-positive bone marrow cells

1993 • 22 citations

Multiple Routes for Late Intrathymic Precursors to Generate CD4+CD8+ Thymocytes

1992 • 22 citations

Purified murine long-term in vivo hematopoietic repopulating cells are not prothymocytes.

1995 • 14 citations

Frequency Analysis of the T Cell Precursors in the Thymus

1993 • 11 citations

CD45RA antibodies split the CD3bright T cell subset

1991 • 8 citations

The fetal thymus stores immature hemopoietic cells capable of differentiating into non-T lineage cells constituting the thymus stromal element

1993 • 8 citations

Persistence of stem cell activity within the murine thymus after transfer of a bone marrow fraction enriched in CFU-S

1991 • 5 citations