CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

1984 • 1,518 citations

CD44 and Its Interaction with Extracellular Matrix

1993 • 1,082 citations

Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

1996 • 930 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

1989 • 680 citations

Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures.

1990 • 574 citations

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

1989 • 568 citations

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

1992 • 542 citations

Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression.

1993 • 541 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Significance of CD44 gene products for cancer diagnosis and disease evaluation

1992 • 470 citations

CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.

1995 • 434 citations

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway.

1996 • 421 citations

Hyaluronan and its binding proteins, the hyaladherins

1990 • 419 citations

Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44

1992 • 417 citations

Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

1994 • 384 citations

Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons.

1991 • 377 citations

CD44 variant exon epitopes in primary breast cancer and length of survival

1995 • 363 citations

A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.

1993 • 352 citations

CD8+ T lymphocytes in intracellular microbial infections

1988 • 335 citations

Dual role of the CD44 molecule in T cell adhesion and activation.

1989 • 335 citations

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

1993 • 330 citations

CD44 contributes to T cell activation.

1989 • 324 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

Distinct effects of two CD44 isoforms on tumor growth in vivo.

1991 • 315 citations

Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration

1996 • 313 citations

Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms.

1994 • 311 citations

Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44.

1993 • 309 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release

1990 • 300 citations

Splicing choice from ten variant exons establishes CD44 variability

1993 • 291 citations

Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis

1991 • 288 citations

A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion.

1992 • 287 citations

LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.

1996 • 277 citations

Differential expression of homing-associated adhesion molecules by T cell subsets in man.

1990 • 270 citations

CD44 splice variants: metastases meet lymphocytes

1993 • 268 citations

Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon.

1995 • 253 citations

The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human, and rat

1993 • 247 citations

The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44

1993 • 245 citations

CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation.

1993 • 241 citations

Cryptosporidium infection in an adult mouse model. Independent roles for IFN-gamma and CD4+ T lymphocytes in protective immunity.

1991 • 235 citations

Antibodies against the CD44 p80, lymphocyte homing receptor molecule augment human peripheral blood T cell activation.

1990 • 230 citations

Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues.

1989 • 215 citations

Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans

1990 • 210 citations

Spleen cell cytokine secretion in Mycobacterium bovis BCG-infected mice

1992 • 171 citations

Persistent Cryptosporidium infection in congenitally athymic (nude) mice

1984 • 167 citations

Expression of CD44 is repressed in neuroblastoma cells.

1991 • 165 citations

Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody.

1994 • 164 citations

Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: cooperation between the integrin alpha 4 beta 1 and the CD44 adhesion receptor

1994 • 161 citations

Hematopoietic progenitor cell expression of the H-CAM (CD44) homing- associated adhesion molecule

1990 • 160 citations

CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer.

1995 • 159 citations

Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth

1994 • 153 citations

Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo.

1993 • 152 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning

1993 • 149 citations

CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells

1992 • 144 citations

Impaired primary T cell responses in L-selectin-deficient mice.

1996 • 143 citations

Expression of CD44 confers a new adhesive phenotype on transfected cells

1990 • 138 citations

Molecular cloning and expression of Pgp-1. The mouse homolog of the human H-CAM (Hermes) lymphocyte homing receptor.

1989 • 133 citations

Are CD44 variant isoforms involved in human tumour progression?

1995 • 129 citations

Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor.

1989 • 129 citations

Localization of the CD44 Glycoprotein to Fibrous Astrocytes in Normal White Matter and to Reactive Astrocytes in Active Lesions in Multiple Sclerosis

1991 • 122 citations

Role of CD44 cytoplasmic domain in hyaluronan binding

1995 • 119 citations

T-cell-receptor-independent activation of cytolytic activity of cytotoxic T lymphocytes mediated through CD44 and gp90MEL-14.

1991 • 112 citations

Sequential production of Th1 and Th2 cytokines in response to live bacillus Calmette-Guérin.

1995 • 102 citations

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

1996 • 101 citations

Thymic stem cells in mouse bone marrow

1994 • 101 citations

Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains.

1989 • 99 citations

Isolation of mouse CD44 cDNA: structural features are distinct from the primate cDNA.

1989 • 94 citations

Localization of hyaluronan in mouse embryos during implantation, gastrulation and organogenesis

1993 • 93 citations

Aggregation of macrophages and fibroblasts is inhibited by a monoclonal antibody to the hyaluronate receptor

1988 • 92 citations

Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain.

1995 • 90 citations

CD44 (Pgp-1) inhibits CD3 and dexamethasone-induced apoptosis

1995 • 90 citations

Molecular basis of the recognition of intravenously transplanted hemopoietic cells by bone marrow.

1988 • 89 citations

Clinical relevance of CD44 cell-surface expression and N-myc gene amplification in a multicentric analysis of 121 pediatric neuroblastomas.

1996 • 89 citations

Determination of total and merecaptothanol-resistant antibody in the same serum sample.

1970 • 89 citations

Antibodies to CD44 trigger effector functions of human T cell clones.

1993 • 87 citations

In vitro homing of hemopoietic stem cells is mediated by a recognition system with galactosyl and mannosyl specificities.

1987 • 86 citations

Expression of CD44 isoforms in renal cell tumors. Positive correlation to tumor differentiation.

1996 • 86 citations

The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouse

1991 • 86 citations

Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia

1995 • 85 citations

Expression of a human homing receptor (CD44) in lymphoid malignancies and related stages of lymphoid development.

1990 • 85 citations

Hyaluronate binding and CD44 expression in human glioblastoma cells and astrocytes

1992 • 76 citations

Genetic characterization of a polymorphic murine cell-surface glycoprotein

1982 • 75 citations

The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate

1993 • 75 citations

CD44 triggering enhances human NK cell cytotoxic functions.

1994 • 75 citations

Worm Sperm and Advances in Cell Locomotion

1996 • 75 citations

High levels of CD44 expression distinguish virgin from antigen-primed B cells.

1991 • 73 citations

CD44: physiological expression of distinct isoforms as evidence for organ-specific metastasis formation

1995 • 65 citations

Human T cell activation by OKT3 is inhibited by a monoclonal antibody to CD44.

1991 • 64 citations

Cell surface CD44-related chondroitin sulfate proteoglycan is required for transforming growth factor-β-stimulated mouse melanoma cell motility and invasive behavior on type I collagen

1993 • 63 citations

H-CAM expression in the human nervous system: Evidence for a role in diverse glial interactions

1992 • 63 citations

CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells.

1989 • 62 citations

Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium lonophore

1988 • 60 citations

Peripheral T lymphocyte depletion by apoptosis after CD4 ligationin vivo: selective loss of CD44− and ‘activating’ memory T cells

1994 • 58 citations

Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation

1989 • 57 citations

Activation of CD44 induces ICAM‐1/LFA‐1‐independent, Ca²⁺, Mg²⁺, —independent adhesion pathway in lymphocyte‐endothelial cell interaction

1993 • 56 citations

In vitro Proliferation and Production of Gamma Interferon by Murine CD4 + Cells in Response to Cryptosporidium parvum Antigen

1994 • 54 citations

Chapter 25 Embryo-Derived Stem Cells: A Tool for Elucidating the Developmental Genetics of the Mouse

1986 • 53 citations

Stimulation of human monocytes via CD45, CD44, and LFA-3 triggers macrophage-colony-stimulating factor production. Synergism with lipopolysaccharide and IL-1 beta.

1992 • 53 citations

Regulation of Lymphocyte Traffic to Mucosa-Associated Lymphatic Tissues

1991 • 53 citations

Expression of variant CD44-messenger RNA in colorectal adenocarcinomas and adenomatous polyps in humans

1996 • 52 citations

The MHC class‐II and CD44 molecules are involved in the induction of tumour necrosis factor (TNF) gene expression by human monocytes stimulated with tumour cells

1994 • 48 citations

Lymphocyte Migration into the Skin: The Role of Lymphocyte Homing Receptor (CD44) and Endothelial Cell Antigen (HECA-452)

1990 • 47 citations

CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas.

1995 • 47 citations

Localization of hyaluronan in mouse embryos during implantation, gastrulation and organogenesis

1993 • 47 citations

An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus

1988 • 46 citations

CD44 standard and variant isoform expression in human epidermal skin tumors is not correlated with tumor aggressiveness but down-regulated during proliferation and tumor de-differentiation

1996 • 45 citations

Qualitative and quantitative heterogeneity in Pgp-1 expression among murine thymocytes

1988 • 40 citations

The protein fold of the hyaluronate‐binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C‐type lectin superfamily

1996 • 37 citations

Expression of CD44 molecules and CD44 ligands during human thymic fetal development: expression of CD44 isoforms is developmentally regulated

1995 • 37 citations

Monoclonal Anti-CD44 Antibody Acts in Synergy with Anti-CD2 but Inhibits Anti-CD3 or T Cell Receptor-Mediated Signaling in Murine T Cell Hybridomas

1993 • 35 citations

CD44 plays a co-stimulatory role in murine T cell activation: ligation of CD44 selectively co-stimulates IL-2 production, but not proliferation in TCR-stimulated murine T_h1 cells

1995 • 33 citations

Differentiation and prognosis of neuroblastoma in correlation to the expression of CD44s

1995 • 30 citations

Stimulation of IFN-γ, TNF-α, and TNF-β secretion in IL-2-activated T cells: Costimulatory roles for LFA-1, LFA-2, CD44, and CD45 molecules

1992 • 27 citations

Localization of CD44 (P80) on the external surface of a human astrocytoma cell

1991 • 23 citations

Mechanisms of Enhancement of Natural Killer Activity by an Antibody to CD44: Increase in Conjugate Formation and Release of Tumor Necrosis Factor α

1995 • 22 citations

Genetic alterations associated with metastatic dissemination and chemoresistance in neuroblastoma

1995 • 19 citations

Ontogeny of fetal CD8^lo4^lo thymocytes: Expression of CD44, CD25 and early expression of TcR α mRNA

1993 • 19 citations

Thymic stem cells in mouse bone marrow

1994 • 15 citations

CD44 Is Involved in Porcine Natural Cytotoxicity

1993 • 9 citations

CD44 (Pgp-1) inhibits CD3 and dexamethasone-induced apoptosis

1995 • 7 citations

Expression of lectin receptors on the surface of granulocyte‐macrophage progenitor cells (CFU‐gm)

1986 • 6 citations

Expression of lectin receptors on the surface of granulocyte‐macrophage progenitor cells (cfu‐gm)

1986 • 4 citations