Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Current protocols in immunology

1992 • 1,464 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody

1979 • 1,144 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1994 • 888 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

1995 • 441 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins

1994 • 384 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Susceptibility to Leishmania major Infection in Interleukin-4-Deficient Mice

1996 • 292 citations

Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response.

1995 • 242 citations

[49] Derivation of embryonic stem cell lines

1993 • 228 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4⁺ T cells which are NK1.1⁻

1995 • 168 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

Immunology of leishmaniasis

1992 • 162 citations

Monoclonal antibodies against murine gamma interferon.

1984 • 153 citations

Pathogen-induced Th1 phenotype development in CD4⁺ αβ-TCR transgenic T cells is macrophage dependent

1993 • 133 citations

Differential effects of interleukin‐12 on the development of naive mouse CD4⁺ T cells

1994 • 132 citations

The role of TH1 and TH2 cells in experimental cutaneous leishmaniasis

1989 • 113 citations

Exacerbation of experimental murine cutaneous leishmaniasis with CD4⁺Leishmania major‐specific T cell lines or clones which secrete interferon‐γ and mediate parasite‐specific delayed‐type hypersensitivity

1991 • 57 citations

Immunity to experimental infection with Leishmania major: generation of protective L3T4⁺ T cell clones recognizing antigen(s) associated with live parasites

1989 • 56 citations

Characterization of anti-mouse IL-12 monoclonal antibodies and measurement of mouse IL-12 by ELISA

1996 • 38 citations