DNA-PK: at the cross-roads of biochemistry and genetics

DNA Repair and Mutagenesis

2006 • 4,725 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks in Saccharomyces cerevisiae

1996 • 733 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Xeroderma Pigmentosum Group F Caused by a Defect in a Structure-Specific DNA Repair Endonuclease

1996 • 537 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints

1995 • 509 citations

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

1996 • 492 citations

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

1993 • 486 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

1986 • 465 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap.

1981 • 430 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

1995 • 386 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

Removal of Nonhomologous DNA Ends in Double-Strand Break Recombination: the Role of the Yeast Ultraviolet Repair Gene RAD1

1992 • 375 citations

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1995 • 370 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

1996 • 349 citations

Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated.

1992 • 345 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.

1995 • 342 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

Accelerated telomere shortening in ataxia telangiectasia

1996 • 334 citations

Molecular characterization of the human excision repair gene : cDNA cloning and amino acid homology with the yeast DNA repair gene

1986 • 330 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

Mechanisms of nonhomologous recombination in mammalian cells.

1985 • 314 citations

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

1993 • 311 citations

VDJ recombination

1992 • 307 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

Initiation of V(D)J recombination in a cell-free system

1995 • 286 citations

The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

1996 • 281 citations

Mutations in Two Ku Homologs Define a DNA End-Joining Repair Pathway in Saccharomyces cerevisiae

1996 • 275 citations

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1989 • 273 citations

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells

1980 • 260 citations

EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA

1993 • 247 citations

The DNA-binding Protein Hdf1p (a Putative Ku Homologue) Is Required for Maintaining Normal Telomere Length in Saccharomyces Cerevisiae

1996 • 246 citations

Menage á trois: Double strand break repair, V(D)J recombination and DNA-PK

1995 • 245 citations

The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast.

1980 • 242 citations

DNA damage and the DNA-activated protein kinase

1993 • 237 citations

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

1994 • 225 citations

RAD1 and RAD10, but Not Other Excision Repair Genes, Are Required for Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae

1995 • 217 citations

Molecular Cloning of cDNA Encoding the p70 (Ku) Lupus Autoantigen

1989 • 212 citations

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

1996 • 211 citations

Analysis of the mechanism of interaction of simian Ku protein with DNA

1991 • 207 citations

Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events.

1994 • 207 citations

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.

1993 • 193 citations

Chromosomal double-strand break repair in Ku80-deficient cells.

1996 • 191 citations

In vivo biochemistry: Physical monitoring of recombination induced by site‐specific endonucleases

1995 • 191 citations

The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination

1996 • 189 citations

Biochemical and Genetic Defects in the DNA-Dependent Protein Kinase in Murine scid Lymphocytes

1996 • 185 citations

Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II

1993 • 184 citations

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA

1990 • 178 citations

Ku80-deficient Cells Exhibit Excess Degradation of Extrachromosomal DNA

1996 • 175 citations

Molecular and Biochemical Characterization of xrs Mutants Defective in Ku80

1997 • 174 citations

Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell

1983 • 170 citations

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

1995 • 167 citations

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination.

1994 • 164 citations

TFIIH: a key component in multiple DNA transactions

1996 • 160 citations

Ku86 Defines the Genetic Defect and Restores X-Ray Resistance and V(D)J Recombination to Complementation Group 5 Hamster Cell Mutants

1996 • 156 citations

Human and mouse homologs of the Saccharomyces cerevisiaeRAD54 DNA repair gene: evidence for functional conservation

1996 • 152 citations

Cell cycle-dependent repair of double-strand DNA breaks in a ?-ray-sensitive Chinese hamster cell

1985 • 150 citations

Relative rates of homologous and nonhomologous recombination in transfected DNA.

1985 • 145 citations

Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts.

1993 • 135 citations

Cell Cycle Responses of Two X-ray Sensitive Mutants Defective in DNA Repair

1989 • 131 citations

cDNA-derived Amino Acid Sequence of the 86-kDa Subunit of the Ku Antigen

1989 • 125 citations

Mammalian mutants defective in the response to ionizing radiation-induced DNA damage

1995 • 122 citations

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.

1995 • 121 citations

Intermolecular recombination between DNAs introduced into mouse L cells is mediated by a nonconservative pathway that leads to crossover products.

1990 • 120 citations

ERCC4 (XPF) Encodes a Human Nucleotide Excision Repair Protein with Eukaryotic Recombination Homologs

1996 • 118 citations

V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder.

1993 • 115 citations

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

1995 • 113 citations

Evidence that mammalian cells possess homologous recombinational repair pathways

1996 • 110 citations

scid Cells Are Deficient in Ku and Replication Protein A Phosphorylation by the DNA-Dependent Protein Kinase

1995 • 109 citations

The cellular responses to DNA damage

1995 • 108 citations

Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination

1994 • 107 citations

MOLECULAR ANALYSIS OF V(D)J RECOMBINATION

1992 • 107 citations

Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line

1986 • 97 citations

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction

1996 • 94 citations

Double-strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants

1985 • 94 citations

Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines

1991 • 91 citations

Characterization of an X-ray-hypersensitive mutant of V79 Chinese hamster cells

1988 • 83 citations

DNA-Dependent ATPase from HeLa Cells Is Related to Human Ku Autoantigen

1994 • 79 citations

Homologous, homeologous, and illegitimate repair of double-strand breaks during transformation of a wild-type strain and a rad52 mutant strain of Saccharomyces cerevisiae.

1994 • 74 citations

Nomenclature of human genes involved in ionizing radiation sensitivity

1995 • 73 citations

The genetic basis of resistance to ionising radiation damage in cultured mammalian cells

1991 • 72 citations

Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.

1995 • 71 citations

Production and characterization of recombinant human Ku antigen

1994 • 69 citations

DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

1995 • 63 citations

p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts.

1996 • 59 citations

Gene recombination in X-ray-sensitive hamster cells.

1987 • 58 citations

Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination

1995 • 55 citations

A Double-Strand Break within a Yeast Artificial Chromosome (YAC) Containing Human DNA Can Result in YAC Loss, Deletion, or Cell Lethality

1996 • 51 citations

X-ray sensitive mutants of Chinese hamster ovary cell line: radio-sensitivity of DNA synthesis

1985 • 47 citations

Loss of S-phase-dependent radioresistance in irs-1 cells exposed to X-rays

1994 • 46 citations

Genotoxicity of γ-irradiation in L5178Y mouse lymphoma cells

1986 • 39 citations

The ataxia-telangiectasia gene: a link between checkpoint controls, neurodegeneration and cancer

1995 • 37 citations

Homologous recombination in a Chinese hamster X-ray-sensitive mutant

1986 • 36 citations

Dose-rate effect on induction and repair rate of radiation-induced DNA double-strand breaks in a normal and an ataxia telangiectasia human fibroblast cell line

1995 • 33 citations

Ku is a general inhibitor of DNA-protein complex formation and transcription

1996 • 32 citations

DNA double-strand break rejoining in xrs5 cells is more rapid in the G2 than in the G1 phase of the cell cycle

1994 • 29 citations

An Ionizing Radiation-Sensitive CHO Mutant Cell Line: irs-20. IV. Genetic Complementation, V(D)J Recombination and the scid Phenotype

1997 • 26 citations

Decreased stable transfection frequencies of six X-ray-sensitive CHO strains, all members of the xrs complementation group

1989 • 26 citations

Biochemical and cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6 V. The correlation of DNA strand breaks and base damage to chromosomal aberrations and sister-chromatid exchanges induced by X-irradiation

1990 • 25 citations

The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

1996 • 21 citations

Use of Damaged Plasmid to Study DNA Repair in X-ray Sensitive(Xrs)Strains of Chinese Hamster Ovary (CHO) Cells

1989 • 20 citations

Differential gene expression in wild-type and X-ray-sensitive mutants of Chinese hamster ovary cell lines

1992 • 9 citations

Deleted Work

1955 • 0 citations