Are the IL-2 Receptors Expressed in the Murine Fetal Thymus Functional?

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization.

1986 • 740 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells.

1985 • 305 citations

Cell growth cycle block of T cell hybridomas upon activation with antigen.

1987 • 235 citations

Expression and function of interleukin-2 receptors on immature thymocytes

1985 • 217 citations

The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.

1984 • 214 citations

Developmental Status and Reconstitution Potential of Subpopulations of Murine Thymocytes

1988 • 211 citations

Unique structure of murine interleukin-2 as deduced from cloned cDNAs

1985 • 205 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.

1985 • 162 citations

Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors

1987 • 124 citations

Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2

1985 • 108 citations

Cell proliferation and differentiation in the fetal and early postnatal mouse thymus.

1989 • 104 citations

Interleukin 2 upregulates expression of its receptor on a T cell clone.

1985 • 102 citations

Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.

1988 • 95 citations

The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit.

1987 • 91 citations

The differentiation of murine thymocytes in vivo and in vitro.

1978 • 76 citations

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.

1989 • 70 citations

Early genetic events in T cell development analyzed by in situ hybridization.

1987 • 68 citations

Human thymic epithelial cells directly induce activation of autologous immature thymocytes.

1988 • 67 citations

Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

1988 • 65 citations

Human T‐Cell Precursors: Involvement of the IL‐2 Pathway in the Generation of Mature T Cells

1988 • 63 citations

Functional status of interleukin 2 receptors expressed by immature (Lyt-2-/L3T4-) thymocytes.

1986 • 60 citations

Differentiation potential of 14-day fetal mouse thymocytes in organ culture. Analysis of CD4/CD8-defined single-positive and double-negative cells.

1988 • 53 citations

Expression of interleukin 2 receptor on murine fetal thymocytes

1985 • 53 citations

Control of prothymocyte proliferation by thymic accessory cells

1987 • 35 citations

Mouse fetal thymus lobes cultured in IL-2 generate CD3+, TCR-gamma delta-expressing CD4-/CD8+ and CD4-/CD8- cells.

1989 • 31 citations

Developmentally controlled expression of IL 2 receptors and of sensitivity to IL 2 in a subset of embryonic thymocytes.

1985 • 25 citations

Activation of the interleukin 2 pathway precedes CD3‐T cell receptor expression in thymic development. Differential growth requirements of early and mature intrathymic subpopulations

1989 • 20 citations

Detection of rearranged T cell receptor β‐chain gene and induction of cytolytic function in interleukin 2‐ responsive day 14–15 murine fetal thymocytes

1986 • 9 citations