Domains of the TCR beta-chain required for early thymocyte development.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

1984 • 642 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

1984 • 528 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

1989 • 499 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Structure, Organization and Polymorphism of Murine and Human T‐Cell Receptor a and β Chain Gene Families

1988 • 448 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

The T Cell Antigen Receptor: Insights into Organelle Biology

1990 • 361 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells

1986 • 225 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex

1986 • 210 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Genomic organization of the genes encoding mouse T-cell receptor α-chain

1985 • 202 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

1987 • 179 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

The genes coding for the cytoskeletal proteins actin and vimentin in warm-blooded vertebrates.

1982 • 136 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.

1988 • 100 citations

Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene.

1993 • 85 citations

Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins.

1991 • 82 citations

Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes

1996 • 82 citations

T cell depletion in transgenic mice carrying a mutant gene for TCR-β

1989 • 77 citations

Selection of V_H gene repertoires: differentiating B cells of adult bone marrow mimic fetal development

1990 • 74 citations

The structure of the μ/pseudo light chain complex on human pre‐B cells is consistent with a function in signal transduction

1993 • 56 citations

Genomic organization of the mouse T-cell receptor beta-chain gene family.

1987 • 48 citations

T cell receptor-alpha beta lacking the beta-chain V domain can be expressed at the cell surface but prohibits T cell maturation.

1992 • 31 citations

The T Cell Antigen Receptor: Insights Into Organelle Biology

1990 • 20 citations

Ontogeny of T-cell receptor gene expression

1987 • 8 citations