p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

p53 function and dysfunction

1992 • 1,918 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Control points in early T-cell development

1993 • 429 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

High Incidence of Lung, Bone, and Lymphoid Tumors in Transgenic Mice Overexpressing Mutant Alleles of the p53 Oncogene

1989 • 109 citations

Status of the p53 tumor suppressor gene in human squamous carcinoma cell lines.

1992 • 88 citations

Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection

1995 • 68 citations

p53 mutations in C57BL/6J murine thymic lymphomas induced by gamma-irradiation and N-methylnitrosourea.

1992 • 66 citations

Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice.

1994 • 62 citations

Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation.

1990 • 58 citations

Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells.

1993 • 50 citations

Negative and positive selection of immature thymocytes: timing and the role of the ligand for alpha beta T cell receptor.

1990 • 39 citations

CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire.

1991 • 18 citations