T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Negative selection of lymphocytes

1994 • 810 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

The T Cell Receptor

1987 • 554 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Selective Events in T Cell Development

1994 • 486 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1989 • 331 citations

Activation events during thymic selection.

1992 • 326 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

1982 • 252 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1993 • 225 citations

Practical design criteria for a dynamic ratio imaging system

1990 • 198 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.

1988 • 160 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

The majority of CD4+8- thymocytes are functionally immature.

1991 • 137 citations

The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex.

1994 • 135 citations

Inhibition of T Cell Receptor Expression and Function in Immature CD4 ⁺ cD8 ⁺ Cells by CD4

1990 • 129 citations

Influence of the Major Histocompatibility Complex on Positive Thymic Selection of V_β17a⁺T Cells

1989 • 110 citations

Simultaneous analysis of immunophenotype and apoptosis of murine thymocytes by single laser flow cytometry

1992 • 99 citations

Functionally distinct subsites on a class II major histocompatibility complex molecule

1987 • 95 citations

Development of Mature CD8⁺Thymocytes: Selection Rather Than Instruction?

1993 • 94 citations

Cytotoxic T cell clone‐specific monoclonal antibodies used to select clonotypic antigen‐specific cytotoxic T cells

1985 • 90 citations

Apoptosis And Programmed Cell Death In Immunity

1992 • 89 citations

Induction of MHC-restricted specificity and tolerance in the thymus

1986 • 82 citations

In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands

1992 • 72 citations

Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.

1994 • 64 citations

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

1993 • 62 citations

The Ca²⁺/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene

1994 • 62 citations

Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus

1990 • 51 citations

Activation of murine T lymphocytes with monoclonal antibodies: detection on Lyt-2+ cells of an antigen not associated with the T cell receptor complex but involved in T cell activation.

1987 • 51 citations

Selective Events in T Cell Development

1994 • 37 citations

Cyclosporine, Tolerance, and Autoimmunity

1993 • 35 citations

Effect of cyclosporin A on lymphopoiesis. I. Absence of mature T cells in thymus and periphery of bone marrow transplanted mice treated with cyclosporin A.

1989 • 35 citations

Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.

1991 • 31 citations

Relationship of cyclosporine A-mediated inhibition of clonal deletion and development of syngeneic graft-versus-host disease.

1991 • 23 citations

Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages.

1993 • 22 citations

A novel form of self tolerance dictated in the thymus of transgenic mice with autoreactive TCR α and β chain genes

1994 • 15 citations

Bioimaging of myeloperoxidase release into phagolysosome of viable polymorphonuclear leukocytes and reaction of the enzyme with microspheres using a highly sensitive analyzer system

1993 • 4 citations