Intrathymic δ Selection Events in γδ Cell Development

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Notch Signaling

1995 • 1,282 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

Positive Selection of Thymocytes

1995 • 604 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Selective Events in T Cell Development

1994 • 486 citations

Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes

1993 • 474 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1996 • 343 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Interleukin 7 receptor-deficient mice lack gammadelta T cells.

1996 • 316 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

1990 • 306 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Developmental potential of the earliest precursor cells from the adult mouse thymus.

1991 • 294 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

1994 • 238 citations

Self-reactive γδ T cells are eliminated in the thymus

1990 • 221 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

αβ lineage-specific expression of the α T cell receptor gene by nearby silencers

1989 • 182 citations

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

1995 • 180 citations

Differentiation potential of subsets of CD4−8− thymocytes

1987 • 169 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro.

1990 • 143 citations

α β and γ δ T cells can share a late common precursor

1995 • 139 citations

Rapid staining methods for analysis of deoxyribonucleic acid and protein in mammalian cells.

1976 • 134 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

Separate lineages of T cells expressing the αβ and γδ receptors

1989 • 118 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

Identification of early stages of T lymphocyte development in the thymus cortex and medulla.

1985 • 103 citations

Positive Selection of Thymocytes

1995 • 103 citations

Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.

1990 • 99 citations

Peripheral lymphoid development and function in TCR mutant mice

1994 • 97 citations

T Cell Receptor δ Gene Rearrangement and T Early α (TEA) Expression in Immature αβ LineageThymocytes: Implications for αβ/γδ Lineage Commitment

1996 • 96 citations

Selection is not required to produce invariant T-cell receptor γ-gene junctional sequences

1993 • 94 citations

TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development.

1996 • 88 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

The kinetics of immature murine thymocyte development in vivo

1990 • 77 citations

Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.

1996 • 76 citations

Subpopulations of early thymocytes. A cross-correlation flow cytometric analysis of adult mouse Ly-2-L3T4-(CD8-CD4-) thymocytes using eight different surface markers.

1988 • 63 citations

The role of short homology repeats and TdT in generation of the invariant γδ antigen receptor repertoire in the fetal thymus

1995 • 62 citations

Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination.

1994 • 59 citations

Characterization of the subset of immature thymocytes which can undergo rapid in vitro differentiation

1989 • 54 citations

Development of immature thymocytes: initiation of CD3, CD4, and CD8 acquisition parallels down‐regulation of the interleukin 2 receptor α chain

1990 • 53 citations

Intrathymic differentiation of V gamma 3 T cells.

1993 • 48 citations

Inhibition of thymocyte negative selection by T cell receptor antagonist peptides

1996 • 36 citations

Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement.

1995 • 36 citations

_γδ T cells promote CD4 and CD8 expression by SCID thymocytes

1993 • 35 citations

Subpopulations of CD4-CD8-murine thymocytes: differences in proliferation rate in vivo and proliferative responses in vitro

1988 • 32 citations

Development of γδ T cells in the adult murine thymus

1993 • 30 citations

The level of N‐region diversity in T cell receptors is not pre‐ordained in the stem cell

1993 • 30 citations

Emigration of selected subsets of γδ⁺ T cells from the adult murine thymus

1993 • 29 citations

Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation.

1993 • 23 citations

A δ T-Cell Receptor Deleting Element Transgenic Reporter Construct Is Rearranged in αβ but not γδ T-Cell Lineages

1995 • 18 citations

Different patterns of TCR transgene expression in single-positive and double-negative T cells. Evidence for separate pathways of T cell maturation.

1996 • 14 citations

Extensive N nucleotide addition in junctional region of T cell receptor Vγ5 genes rearranged in fetal liver‐derived thymocytes in radiation chimera mice

1993 • 9 citations

T Cell Receptor, γδ

1998 • 7 citations

Deleted Work

1955 • 0 citations