Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

1984 • 638 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium.

1991 • 326 citations

The interleukins ¹

1989 • 276 citations

T-Cell Differentiation is Influenced by Thymic Microenvironments

1991 • 239 citations

IL-1 receptor antagonist and IL-1 beta production in human monocytes are regulated differently.

1991 • 219 citations

Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon-gamma (IFN-gamma).

1985 • 184 citations

Effect of IL-7 on the growth of fetal thymocytes in culture.

1989 • 179 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

Synergy of tumor necrosis factor and interleukin 2 in the activation of human cytotoxic lymphocytes: effect of tumor necrosis factor alpha and interleukin 2 in the generation of human lymphokine-activated killer cell cytotoxicity.

1988 • 172 citations

Cytokines in T-cell development

1991 • 164 citations

Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines.

1988 • 164 citations

CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation

1991 • 155 citations

Human thymic epithelial cells produce interleukin 1.

1987 • 136 citations

IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing alpha beta or gamma delta T-cell receptors in vitro: synergism with IL-2.

1989 • 119 citations

Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor.

1990 • 116 citations

Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.

1990 • 109 citations

Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level.

1991 • 109 citations

Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors.

1988 • 97 citations

Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes.

1990 • 84 citations

Synergy of human recombinant interleukin 1 with interleukin 2 in the generation of lymphokine-activated killer cells.

1989 • 74 citations

Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation.

1987 • 70 citations

Development of human T lymphocytes and their thymus-dependency.

1990 • 70 citations

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.

1989 • 70 citations

Cytokine production by mature and immature thymocytes.

1991 • 69 citations

Human thymic epithelial cells directly induce activation of autologous immature thymocytes.

1988 • 67 citations

Cytokine-induced IL-1 beta gene expression in the human polymorphonuclear leukocyte: transcriptional and post-transcriptional regulation by tumor necrosis factor and IL-1.

1991 • 66 citations

Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset.

1991 • 65 citations

Constitutive expression and role in growth regulation of interleukin-1 and multiple cytokine receptors in a biphenotypic leukemic cell line

1991 • 64 citations

Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivo.

1991 • 56 citations

Human thymic epithelial cells produce interleukin-3

1991 • 55 citations

Concomitant production of different lymphokines in activated T cells

1988 • 52 citations

Interferon-gamma is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes.

1987 • 50 citations

IL-7 supports the generation of cytotoxic T lymphocytes from thymocytes. Multiple lymphokines required for proliferation and cytotoxicity.

1990 • 49 citations

Human thymic epithelium and T cell development: current issues and future directions.

1990 • 48 citations

Thymic microenvironment induces HIV expression:physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells

1992 • 45 citations

Thymic stroma is required for the development of human T cell lineages in vitro

1989 • 38 citations

Production of IL-1 alpha by activated Th type 2 cells. Its role as an autocrine growth factor.

1991 • 35 citations

Activation of lymphokine genes during stimulation of cloned T cells

1986 • 18 citations

Delineation of human thymocytes with or without functional potential by CD1-specific antibodies

1989 • 15 citations

Immunohistology of lymphoid organs

1989 • 13 citations

Interplay between IL-2 and IL-4 in human thymocyte differentiation: antagonism or agonism

1991 • 13 citations