Natural killer cell receptors

RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS

1996 • 871 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes

1996 • 599 citations

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.

1995 • 507 citations

Protection from Natural Killer Cell-Mediated Lysis by HLA-G Expression on Target Cells

1996 • 489 citations

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.

1996 • 441 citations

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

1996 • 365 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

1996 • 362 citations

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.

1996 • 349 citations

A human killer inhibitory receptor specific for HLA-A1,2.

1996 • 347 citations

Sequential Involvement of Lck and SHP-1 with MHC-Recognizing Receptors on NK Cells Inhibits FcR-Initiated Tyrosine Kinase Activation

1996 • 341 citations

Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.

1996 • 340 citations

Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer

1995 • 338 citations

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

1996 • 337 citations

Superantigen-Dependent, Cell-Mediated Cytotoxicity Inhibited by MHC Class I Receptors on T Lymphocytes

1995 • 316 citations

Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

1995 • 308 citations

The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 • 271 citations

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor

1997 • 252 citations

Arousal and inhibition of human NK cells

1997 • 249 citations

The Role of Ly49A and 5E6(Ly49C) Molecules in Hybrid Resistance Mediated by Murine Natural Killer Cells Against Normal T Cell Blasts

1996 • 234 citations

Triggering of Natural Killer Cells by the Costimulatory Molecule CD80 (B7-1)

1996 • 233 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.

1997 • 229 citations

Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production

1995 • 221 citations

Mouse Ly-49A Interrupts Early Signaling Events in Natural Killer Cell Cytotoxicity and Functionally Associates with the SHP-1 Tyrosine Phosphatase

1997 • 216 citations

Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones.

1995 • 216 citations

The Ly-49D Receptor Activates Murine Natural Killer Cells

1996 • 213 citations

The role of natural killer cells in host—parasite interactions

1995 • 209 citations

CD94 and a Novel Associated Protein (94AP) Form a NK Cell Receptor Involved in the Recognition of HLA-A, HLA-B, and HLA-C Allotypes

1996 • 187 citations

Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells

1995 • 180 citations

Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type.

1993 • 178 citations

Major histocompatibility complex class I‐dependent skewing of the natural killer cell Ly49 receptor reportoire

1996 • 167 citations

Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3

1996 • 163 citations

Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE.

1996 • 160 citations

The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1.

1997 • 159 citations

Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibililty complex haplotype.

1996 • 158 citations

IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells.

1996 • 148 citations

Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells.

1996 • 142 citations

A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705.

1996 • 140 citations

Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells

1997 • 139 citations

CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies

1996 • 133 citations

Killer Cell Inhibitory Receptor Recognition of Human Leukocyte Antigen (HLA) Class I Blocks Formation of a pp36/PLC-γ Signaling Complex in Human Natural Killer (NK) Cells

1996 • 133 citations

A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation

1996 • 130 citations

Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection.

1996 • 120 citations

An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.

1996 • 119 citations

Heterogeneity Among Ly-49C Natural Killer (NK) Cells: Characterization of Highly Related Receptors with Differing Functions and Expression Patterns

1996 • 119 citations

Mouse natural killer cells express gp49B1, a structural homologue of human killer inhibitory receptors.

1997 • 116 citations

Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49.

1994 • 114 citations

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles.

1996 • 109 citations

Isolation and characterization of a unique natural killer cell inhibitory factor present in the anterior chamber of the eye.

1996 • 107 citations

Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells

1997 • 104 citations

Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions.

1996 • 102 citations

The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand.

1996 • 94 citations

Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells.

1997 • 90 citations

Enhancement of Class II-Restricted T cell Responses by Costimulatory NK Receptors for Class I MHC Proteins

1996 • 89 citations

Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule.

1996 • 88 citations

Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I.

1995 • 84 citations

Natural killer cell receptors and MHC class I interactions

1997 • 77 citations

Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.

1996 • 58 citations

Recognition events that inhibit and activate natural killer cells

1996 • 54 citations

Human natural killer cell inhibitory receptors bind to HLA class I molecules

1996 • 52 citations

Expression of HLA-C molecules confers target cell resistance to some non-major histocompatibility complex-restricted T cells in a manner analogous to allospecific natural killer cells.

1995 • 44 citations

Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes.

1996 • 42 citations

Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition

1996 • 38 citations

Ly-49 G2⁺ NK cells are responsible for mediating the rejection of H-2^b bone marrow allog rafts in mice

1996 • 36 citations

The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles

1997 • 34 citations

Genes in two MHC class I regions control recognition of a single rat NK cell allodeterminant

1996 • 31 citations