Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The Fas Death Factor

1995 • 4,070 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Apoptosis of T cells mediated by galectin-1

1995 • 1,056 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

The biochemistry of programmed cell death

1995 • 997 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Superoxide Production by the Mitochondrial Respiratory Chain

1997 • 909 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1997 • 801 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

1996 • 768 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.

1992 • 692 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.

1995 • 675 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

1992 • 654 citations

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

1996 • 653 citations

A License to Kill

1996 • 649 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Calcium‐mediated cell injury and cell death

1995 • 638 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin Exposure

1996 • 610 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Lamin proteolysis facilitates nuclear events during apoptosis.

1996 • 587 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Acute Myocardial Infarction in Humans is Associated with Activation of Programmed Myocyte Cell Death in the Surviving Portion of the Heart

1996 • 515 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Complex Complexes: Signaling at the TCR

1996 • 512 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Signal transduction through lipid second messengers

1996 • 496 citations

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

1996 • 488 citations

Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus.

1996 • 485 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

1996 • 481 citations

The p75 neurotrophin receptor

1994 • 480 citations

A Subfamily of P-Type ATPases with Aminophospholipid Transporting Activity

1996 • 472 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

The thymic microenvironment

1993 • 459 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

How the λ repressor and cro work

1980 • 452 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

1997 • 440 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1997 • 417 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.

1996 • 407 citations

T Cell Selection in the Thymus

1988 • 405 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

1997 • 387 citations

Constitutive expression of the machinery for programmed cell death.

1996 • 386 citations

Phosphatidylserine Externalization during CD95-induced Apoptosis of Cells and Cytoplasts Requires ICE/CED-3 Protease Activity

1996 • 386 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

1996 • 382 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

1995 • 377 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis.

1996 • 353 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

The cell-death machine

1996 • 351 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

p53 in signaling checkpoint arrest or apoptosis

1996 • 336 citations

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

1996 • 335 citations

A death-domain-containing receptor that mediates apoptosis

1996 • 333 citations

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

1996 • 331 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis.

1997 • 326 citations

Activation events during thymic selection.

1992 • 326 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

1994 • 320 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

Tumor necrosis factor receptor superfamily members and their ligands

1994 • 313 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

1997 • 309 citations

Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis

1997 • 308 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Anatomy of TRAF2

1996 • 302 citations

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

1997 • 302 citations

Isolation of an Erythrocyte Membrane Protein that Mediates Ca2+-dependent Transbilayer Movement of Phospholipid

1996 • 301 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.

1996 • 300 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

1997 • 287 citations

Fas Activation of the p38 Mitogen-Activated Protein Kinase Signalling Pathway Requires ICE/CED-3 Family Proteases

1997 • 285 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Structure-Function Comparisons of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1996 • 280 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Protective Effect of N-Acetylcysteine in Tumor Necrosis Factor-α-Induced Apoptosis in U937 Cells: The Role of Mitochondria

1995 • 274 citations

DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis.

1995 • 271 citations

Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor

1996 • 268 citations

The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition

1996 • 266 citations

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion

1994 • 266 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

The ADP-ATP Translocation in mitochondria, a membrane potential controlled transport

1980 • 262 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions.

1996 • 260 citations

Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells.

1995 • 260 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Ceramide signalling and the immune response

1996 • 257 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.

1997 • 254 citations

Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis

1997 • 253 citations

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

1993 • 252 citations

Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

1997 • 251 citations

Apoptosis induction resulting from proteasome inhibition

1996 • 249 citations

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

1997 • 248 citations

Exposure of Phosphatidylethanolamine on the Surface of Apoptotic Cells

1997 • 247 citations

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

1992 • 245 citations

Moslecular and biological characterization of human 4‐1BB and its ligands

1994 • 242 citations

The Role of APO‐1‐Mediated Apoptosis in the Immune System

1994 • 242 citations

TNF-Induced Activation of NF-κB

1995 • 240 citations

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1996 • 238 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

1997 • 238 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis

1996 • 236 citations

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

1992 • 236 citations

ATP Flux Is Controlled by a Voltage-gated Channel from the Mitochondrial Outer Membrane

1996 • 235 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

Stress-induced apoptosis and the sphingomyelin pathway

1997 • 234 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells.

1996 • 229 citations

Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes

1996 • 227 citations

HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.

1996 • 227 citations

Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis

1996 • 225 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

Bcl-x_Lcan inhibit apoptosis in cells that have undergone Fas-induced protease activation

1997 • 222 citations

CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

1996 • 220 citations

Le mythe de Sisyphe

1942 • 218 citations

Circadian rhythm and light regulate opsin mRNA in rod photoreceptors

1989 • 218 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function

1997 • 214 citations

The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

1996 • 213 citations

Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation

1996 • 212 citations

Sphingomyelin breakdown and cell fate

1996 • 212 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

1996 • 210 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

1994 • 210 citations

The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants.

1994 • 210 citations

c-Jun NH2-terminal Kinase-mediated Activation of Interleukin-1β Converting Enzyme/CED-3-like Protease during Anticancer Drug-induced Apoptosis

1997 • 207 citations

The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition

1995 • 207 citations

Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.

1996 • 202 citations

Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes.

1994 • 202 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

CD28 signals through acidic sphingomyelinase.

1995 • 194 citations

Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis.

1996 • 193 citations

Calpain, an upstream regulator of thymocyte apoptosis.

1997 • 191 citations

Non-oxidative Loss of Glutathione in Apoptosis via GSH Extrusion

1995 • 190 citations

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1993 • 185 citations

Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation.

1989 • 185 citations

Involvement of Cellular Proteolytic Machinery in Apoptosis

1997 • 184 citations

The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation

1996 • 180 citations

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

1995 • 178 citations

Chloromethyl-X-rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis

1996 • 178 citations

Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma.

1995 • 178 citations

ATAR, a Novel Tumor Necrosis Factor Receptor Family Member, Signals through TRAF2 and TRAF5

1997 • 176 citations

Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases.

1996 • 175 citations

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1996 • 175 citations

Ceramide: a signal for apoptosis or mitogenesis?

1995 • 173 citations

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

1996 • 173 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

CD27: marker and mediator of T-cell activation?

1994 • 169 citations

Apoptosis by a cytosolic extract from Fas-activated cells.

1995 • 167 citations

Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

1996 • 167 citations

Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival.

1996 • 167 citations

Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus

1994 • 167 citations

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat

1997 • 164 citations

Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli

1996 • 164 citations

Correspondence

1996 • 164 citations

Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca²⁺ and Oxidant Stress

1996 • 163 citations

Glucocorticoid-mediated control of the activation and clonal deletion of peripheral T cells in vivo.

1993 • 163 citations

Native Recombinant Cyclophilins A, B, and C Degrade DNA Independently of Peptidylprolyl cis-trans-Isomerase Activity

1997 • 161 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

The apoptosis endonucleases: cleaning up after cell death?

1994 • 160 citations

Activation of Raf by ionizing radiation

1996 • 158 citations

An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

1995 • 158 citations

The ICE family of cysteine proteases as effectors of cell death.

1996 • 158 citations

The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.

1995 • 158 citations

Chromatin condensation during apoptosis requires ATP

1996 • 157 citations

Evidence for CPP32 Activation in the Absence of Apoptosis during T Lymphocyte Stimulation

1997 • 155 citations

The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation

1994 • 152 citations

A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway

1996 • 150 citations

Apoptosis of immature thymocytes mediated by E2/CD99.

1997 • 149 citations

Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo

1995 • 148 citations

Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers [see comments]

1995 • 147 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

CD30, Th2 cytokines and HIV infections: a complex and fascinating link

1995 • 145 citations

Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells.

1994 • 145 citations

Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target.

1994 • 144 citations

Peroxynitrite causes calcium efflux from mitochondria which is prevented by Cyclosporin A

1994 • 143 citations

The Negative Signaling Molecule SH2 Domain-containing Inositol-Polyphosphate 5-Phosphatase (SHIP) Binds to the Tyrosine-phosphorylated β Subunit of the High Affinity IgE Receptor

1997 • 143 citations

Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.

1994 • 143 citations

JNK, but not MAPK, activation is associated with Fas‐mediated apoptosis in human T cells

1996 • 142 citations

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

1997 • 141 citations

Increased Expression of the Insulin-like Growth Factor-II Gene in Wilms' Tumor Is Not Dependent on Loss of Genomic Imprinting or Loss of Heterozygosity

1996 • 140 citations

Regulation of TCR Signaling by CD45 Lacking Transmembrane and Extracellular Domains

1993 • 138 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2.

1995 • 133 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.

1994 • 133 citations

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.

1997 • 132 citations

Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.

1997 • 131 citations

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

1993 • 131 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin. Recombinant cyclophilins A, B, and C have nuclease activity.

1994 • 130 citations

CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.

1996 • 130 citations

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.

1996 • 130 citations

Molecular Genetics of Murine Lupus Models

1989 • 129 citations

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

1996 • 128 citations

Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells

1996 • 127 citations

Phosphatidylserine Externalization Is a Downstream Event of Interleukin-1β–Converting Enzyme Family Protease Activation During Apoptosis

1997 • 127 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Structure and expression of murine CD30 and its role in cytokine production.

1996 • 126 citations

A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes.

1995 • 125 citations

Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis

1997 • 125 citations

Human Bak Induces Cell Death in Schizosaccharomyces pombe with Morphological Changes Similar to Those with Apoptosis in Mammalian Cells

1997 • 125 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

Cellular Stresses and Cytokines Activate Multiple Mitogen‐Activated‐Protein Kinase Kinase Homologues in PC12 and KB Cells

1996 • 123 citations

Detection of apoptosis in live cells by MitoTracker? Red CMXRos and SYTO dye flow cytometry

1997 • 122 citations

Energy supply and the shape of death in neurons and lymphoid cells

1997 • 122 citations

CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9

1997 • 120 citations

CD30 Ligand Is Frequently Expressed in Human Hematopoietic Malignancies of Myeloid and Lymphoid Origin

1997 • 119 citations

Translocation of Apocytochrome c across the Outer Membrane of Mitochondria

1995 • 119 citations

Detection of Apoptosis and DNA Replication by Differential Labeling of DNA Strand Breaks with Fluorochromes of Different Color

1996 • 119 citations

IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection: correlation with its ability to block culture-induced down-modulation of Bcl-2.

1996 • 119 citations

Hyporesponsiveness of “naive” (CD45RA⁺) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

1990 • 118 citations

Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.

1994 • 117 citations

Ras‐related proteins in signal transduction and growth control

1995 • 115 citations

Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis

1996 • 114 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

Tim23, a Protein Import Component of the Mitochondrial Inner Membrane, Is Required for Normal Activity of the Multiple Conductance Channel, MCC

1997 • 113 citations

T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor

1991 • 113 citations

Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation.

1993 • 113 citations

Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45

1993 • 112 citations

Reconstitution of Phospholipid Scramblase Activity from Human Blood Platelets

1996 • 110 citations

Intracellular redox changes during apoptosis.

1996 • 110 citations

Events in Apoptosis

1996 • 109 citations

Activation requirements for CD4+ T cells differing in CD45R expression.

1992 • 107 citations

No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis

1994 • 107 citations

RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes

1997 • 107 citations

Role of Tyrosine Phosphorylation of HS1 in B Cell Antigen Receptor-mediated Apoptosis

1997 • 107 citations

A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

1993 • 106 citations

Molecular Cloning, Mapping to Human Chromosome 1 q21-q23, and Cell Binding Characteristics of Spα, a New Member of the Scavenger Receptor Cysteine-rich (SRCR) Family of Proteins

1997 • 103 citations

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

1996 • 101 citations

Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system.

1994 • 100 citations

The regulation and function of p21ras in T cells

1992 • 98 citations

Bcl-2 and Hsp27 act at different levels to suppress programmed cell death

1997 • 96 citations

Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease

1994 • 96 citations

Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5.

1994 • 96 citations

Apoptosis in Human Adenocarcinoma HT29 Cells Induced by Exposure to Hypoxia

1995 • 95 citations

Co-ligation of the Antigen and Fc Receptors Gives Rise to the Selective Modulation of Intracellular Signaling in B Cells

1997 • 94 citations

Constitutive synthesis of tumor necrosis factor in the thymus.

1992 • 93 citations

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity.

1995 • 92 citations

Raf regulates positive selection

1996 • 90 citations

The stress activated protein kinase pathway.

1996 • 90 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development.

1994 • 87 citations

Resistance of actin to cleavage during apoptosis

1997 • 87 citations

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

1992 • 84 citations

Regulation of murine B cell growth and differentiation by CD30 ligand

1995 • 83 citations

The Temporal Relationship between Protein Phosphatase, ICE/CED-3 Proteases, Intracellular Acidification, and DNA Fragmentation in Apoptosis

1997 • 82 citations

Human T cells require IL-2 but not G1/S transition to acquire susceptibility to Fas-mediated apoptosis.

1996 • 80 citations

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

1995 • 79 citations

Interleukin-2, Autotolerance, and Autoimmunity

1991 • 79 citations

The Pharmacology of T Cell Apoptosis

1995 • 77 citations

Altered lipid packing identifies apoptotic thymocytes

1993 • 77 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

CD30 ligand expression in nonmalignant and Hodgkin's disease-involved lymphoid tissues.

1996 • 76 citations

Specific CD45 isoforms differentially regulate T cell receptor signaling.

1994 • 74 citations

Identification of a Novel 97 kDa Endonuclease Capable of Internucleosomal DNA Cleavage

1997 • 74 citations

In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands

1992 • 72 citations

Identification of Genes Induced during Apoptosis in T Lymphocytes

1994 • 71 citations

Signaling for death of lymphoid cells

1993 • 71 citations

Primary Structure and Differential Gene Expression of Three Membrane Forms of Guanylyl Cyclase Found in the Eye of the TeleostOryzias latipes

1997 • 71 citations

CD30 ligand is expressed on resting normal and malignant human B lymphocytes

1996 • 71 citations

A region of the 75 kDa neurotrophin receptor homologous to the death domains of TNFR‐I and Fas

1995 • 70 citations

Selective enrichment of T_h1 CD45RB^low CD4⁺ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis

1994 • 69 citations

Differential expression of APO‐1 on human thymocytes: Implications for negative selection?

1994 • 67 citations

Identification of a Cysteine Protease Closely Related to Interleukin‐1β‐Converting Enzyme

1996 • 66 citations

Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations.

1992 • 65 citations

Calcium-dependent, Interleukin 1β-converting Enzyme Inhibitor-insensitive Degradation of Lamin B1 and DNA Fragmentation in Isolated Thymocyte Nuclei

1996 • 65 citations

Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.

1994 • 64 citations

Baculovirus P35 inhibits the glucocorticoid-mediated pathway of cell death.

1997 • 64 citations

CD30 ligation induces nuclear factor‐ϰB activation in human T cell lines

1995 • 64 citations

Perspectives on the mitochondrial multiple conductance channel

1996 • 64 citations

Lymphocyte Ontogeny and Activation in Gene Targeted Mutant Mice

1994 • 64 citations

Structural and biological features of the TNF receptor and TNF ligand superfamilies: Interactive signals in the pathobiology of Hodgkin's disease

1996 • 63 citations

Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines.

1994 • 62 citations

Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection.

1994 • 62 citations

Effects of Mycoplasma fermentans on the myelomonocytic lineage. Different molecular entities with cytokine-inducing and cytocidal potential.

1996 • 61 citations

Two Different Proteases Are Involved in the Proteolysis of Lamin during Apoptosis

1997 • 61 citations

Activation of Hodgkin cells via the CD30 receptor induces autocrine secretion of interleukin-6 engaging the NF-kappabeta transcription factor

1996 • 60 citations

Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts

1993 • 58 citations

CD4/CD8 lineage commitment: back to instruction?

1996 • 57 citations

Disruption of CD8‐dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1992 • 57 citations

Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells

1996 • 56 citations

Compartmentalization of the Peripheral Immune System

1993 • 55 citations

Intracellular signals that mediate thymic negative selection

1994 • 54 citations

Effect of Protease Inhibitors on Early Events of Apoptosis

1996 • 54 citations

The early intracellular production of a reactive oxygen intermediate mediates apoptosis in dexamethasone-treated thymocytes.

1995 • 53 citations

A pre‐existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli

1995 • 53 citations

Peptidyl Aldehyde Inhibitors of Proteasome Induce Apoptosis Rapidly in Mouse Lymphoma RVC Cells

1997 • 52 citations

Endonuclease G from mammalian nuclei is identical to the major endonuclease of mitochondria

1995 • 51 citations

Promotion and Inhibition of Activation‐Induced Apoptosis in T‐Cell Hybridomas by Oncogenes and Related Signals

1994 • 51 citations

CD30 expression in normal and neoplastic lymphoid tissue: biological aspects and clinical implications.

1995 • 51 citations

Apoptosis without decrease of cell DNA content

1995 • 50 citations

DNA Fragmentation Induced by Protease Activation in p53-Null Human Leukemia HL60 Cells Undergoing Apoptosis Following Treatment with the Topoisomerase I Inhibitor Camptothecin: Cell-Free System Studies

1996 • 50 citations

Activation of the Na(+)/H(+) antiporter, Na+/HCO3(-)/CO3(2-) cotransporter, or Cl(-)/HCO3(-) exchanger in spontaneous thymocyte apoptosis.

1996 • 49 citations

T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.

1997 • 48 citations

Crk is required for apoptosis in Xenopus egg extracts

1997 • 48 citations

Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family

1997 • 47 citations

Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45.

1993 • 46 citations

Antiapoptosis potential of bcl-2 oncogene by dephosphorylation

1994 • 46 citations

Modeled structure of the 75-kDa neurotrophin receptor

1995 • 46 citations

CD45RA and CD45RBhigh expression induced by thymic selection events.

1992 • 45 citations

The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes

1994 • 45 citations

Calpain Inhibitors and Serine Protease Inhibitors Can Produce Apoptosis in HL-60 Cells

1996 • 44 citations

Developmental sequence of T200 antigen modifications in murine T cells.

1987 • 44 citations

Lack of correlation between early intracellular calcium ion rises and the onset of apoptosis in thymocytes

1994 • 44 citations

An apoptotic endonuclease activated either by decreasing pH or by increasing calcium

1996 • 43 citations

Resistance of mitochondrial DNA to degradation characterizes the apoptotic but not the necrotic mode of human leukemia cell death

1993 • 42 citations

Purification and characterization of Mycoplasma penetrans Ca2+/Mg2+-dependent endonuclease

1997 • 41 citations

CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.

1992 • 41 citations

Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.

1990 • 41 citations

Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

1992 • 41 citations

The role of oxygen in thymocyte apoptosis

1996 • 40 citations

Temporal Phases in Apoptosis Defined by the Actions of Src Homology 2 Domains, Ceramide, Bcl-2, Interleukin-1β Converting Enzyme Family Proteases, and a Dense Membrane Fraction

1997 • 40 citations

The Role of p56^ICk and p59^fyn Tyrosine Kinases and CD45 Protein Tyrosine Phosphatase in T‐cell Development and Clonal Selection

1993 • 40 citations

A Mitochondrial Signal Peptide fromNeurospora crassaIncreases the Permeability of Isolated Rat Liver Mitochondria

1996 • 39 citations

Engagement of the CD45 molecule induces homotypic adhesion of human thymocytes through a LFA-1/ICAM-3-dependent pathway.

1994 • 38 citations

Cell acidification in apoptosis

1996 • 38 citations

Alterations in the level of CD45 surface expression affect the outcome of thymic selection.

1997 • 38 citations

Signal Transduction, Mitotic Catastrophes, and Death in T‐Cell Development

1994 • 36 citations

Intracellular Calcium Stores Are Not Required for Bcl-2-mediated Protection from Apoptosis

1996 • 36 citations

Zinc inhibits apoptosis upstream of ICE/CED-3 proteases rather than at the level of an endonuclease

1997 • 35 citations

Aurintricarboxylic acid is an inhibitor of mu- and m-calpain.

1995 • 35 citations

Inhibition of topoisomerase II by aurintricarboxylic acid: implications for mechanisms of apoptosis.

1994 • 33 citations

Utilization of an in vitro assay to evaluate chromatin degradation by candidate apoptotic nucleases

1997 • 31 citations

CD30 ligand signal transduction involves activation of a tyrosine kinase and of mitogen-activated protein kinase in a Hodgkin's lymphoma cell line.

1995 • 30 citations

Death of germinal center B cells without DNA fragmentation

1996 • 30 citations

Endo-exonuclease of human leukaemic cells: Evidence for a role in apoptosis

1996 • 29 citations

Activation-induced cell death in proliferating T cells is associated with altered tyrosine phosphorylation of TCR/CD3 subunits.

1994 • 26 citations

The fail-safe paradigm of immunological self-tolerance

1991 • 25 citations

DISRUPTION OF T CELL DEVELOPMENT AND REPERTOIRE SELECTION BY CALCINEURIN INHIBITION IN VIVO

1994 • 25 citations

T cell repertoire and clonal deletion of Mtv superantigen‐reactive T cells in mice lacking CD4 and CD8 molecules

1995 • 24 citations

Mg2+- or Mn2+-Dependent Endonuclease Activities of Human Myeloid Leukemia Cells Capable of Producing Nucleosomal-Size DNA Fragmentation

1997 • 22 citations

Kinetics of Fas-induced apoptosis in thymic organ culture.

1997 • 22 citations

Apoptosis of cells lacking mitochondrial DNA

1996 • 18 citations

The Mitochondrial Membrane Permeability Transition Induced by Inorganic Phosphate or Inorganic Arsenate. A Comparative Study

1997 • 18 citations

Role of CD4⁺CD45RA⁺ T cells in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse

1993 • 18 citations

Tyrosine kinase triggering in thymocytes undergoing positive selection

1992 • 15 citations

Thapsigargin induces mitochondrial dysfunction and apoptosis in the mastocytoma P815 cell line and in mouse thymocytes.

1996 • 14 citations

Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck).

1996 • 9 citations

CD45RA antibodies split the CD3bright T cell subset

1991 • 8 citations

Induction of apoptotic DNA fragmentation and c-jun downregulation in human myeloid leukemia cells by the permeant Ca2+ chelator BAPTA/AM.

1995 • 8 citations