Involvement of Cellular Proteolytic Machinery in Apoptosis

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

The biochemistry of programmed cell death

1995 • 997 citations

Calcium-activated neutral protease (calpain) system: structure, function, and regulation.

1991 • 841 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

Calpain activation in apoptosis

1994 • 445 citations

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1996 • 434 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

Granzymes: exogenous porteinases that induce target cell apoptosis

1995 • 403 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1996 • 368 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Functions of the Proteasome: the Lysis at the End of the Tunnel

1995 • 302 citations

A Cytosolic Granzyme B Inhibitor Related to the Viral Apoptotic Regulator Cytokine Response Modifier A Is Present in Cytotoxic Lymphocytes

1996 • 301 citations

The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

1996 • 295 citations

Cell death in biology and pathology

1981 • 290 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

1996 • 274 citations

Calmodulin-binding proteins as calpain substrates

1989 • 274 citations

ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis

1996 • 267 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

Apoptosis induction resulting from proteasome inhibition

1996 • 249 citations

Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A

1995 • 238 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Plasminogen Activator Inhibitor Type 2 Inhibits Tumor Necrosis Factor α-induced Apoptosis

1995 • 225 citations

[43] Interleukin-1β converting enzyme

1994 • 208 citations

Review

1995 • 202 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases

1996 • 198 citations

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1996 • 175 citations

Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: Involvement of calcium-activated proteases

1995 • 146 citations

An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor

1996 • 146 citations

Ubiquitin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis.

1993 • 124 citations

Apoptosis — Molecular mechanisms and biomedical implications

1996 • 113 citations

Nuclear Transport of Granzyme B (Fragmentin-2)

1996 • 104 citations

Localization of Granzyme B in the Nucleus

1996 • 102 citations

The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury.

1995 • 101 citations

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

1996 • 101 citations

Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways

1995 • 78 citations

Cell ageing and cell death

1985 • 67 citations

Proteases in apoptosis

1996 • 59 citations

Cell ageing and cell death

1985 • 55 citations

Association of Human Fas (CD95) with a Ubiquitin-conjugating Enzyme (UBC-FAP)

1996 • 54 citations

Proteinase Inhibitor 6 Cannot Be Secreted, Which Suggests It Is a New Type of Cellular Serpin

1996 • 54 citations

Molecular Cloning of Bomapin (Protease Inhibitor 10), a Novel Human Serpin That Is Expressed Specifically in the Bone Marrow

1995 • 51 citations

Calpain and cell death.

1996 • 42 citations

Specific Developmental Changes in the Regulatory Subunits of the 26 S Proteasome in Intersegmental Muscles Preceding Eclosion inManduca sexta

1996 • 35 citations

Binding of Granzyme B in the Nucleus of Target Cells

1996 • 34 citations

Programmed cell death in the tobacco hornworm,Manduca sexta: Alteration in protein synthesis

1996 • 26 citations