Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Negative selection of lymphocytes

1994 • 810 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

p53 mutations increase resistance to ionizing radiation.

1993 • 573 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

1993 • 397 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Steroid production in the thymus: implications for thymocyte selection.

1994 • 351 citations

A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues.

1994 • 341 citations

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1994 • 335 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

1993 • 314 citations

Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)

1995 • 273 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids.

1995 • 230 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Identification of a new brain-specific transcription factor, NURR1

1992 • 229 citations

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.

1992 • 181 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene.

1994 • 147 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.

1988 • 142 citations

Differential effects of Bcl-2 on T and B cells in transgenic mice.

1992 • 140 citations

Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses.

1993 • 138 citations

Functional domains and phosphorylation of the orphan receptor Nur77.

1993 • 128 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Tolerance in Transgenic Mice Expressing Major Histocompatibility Molecules Extrathymically on Pancreatic Cells

1990 • 117 citations

Production, selection, and maturation of thymocytes with high surface density of TCR.

1994 • 113 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

Apoptosis And Programmed Cell Death In Immunity

1992 • 89 citations

Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

1993 • 78 citations

The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

1994 • 76 citations

Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice.

1992 • 71 citations

Transgenic rearranged T cell receptor gene inhibits lymphadenopathy and accumulation of CD4-CD8-B220+ T cells in lpr/lpr mice.

1990 • 64 citations

The Orphan Receptors NGFI-B and Steroidogenic Factor 1 Establish Monomer Binding as a Third Paradigm of Nuclear Receptor-DNA Interaction

1993 • 62 citations

Altered expression of self-reactive T cell receptor V beta regions in autoimmune mice.

1990 • 60 citations

Analysis of specificity for antigen, Mls, and allogeneic MHC by transfer of T-cell receptor α- and β-chain genes

1988 • 52 citations

Developmental regulation of bcl-2 expression in the thymus.

1994 • 51 citations

Distinct requirements of positive and negative selection for selecting cell type and CD8 interaction.

1993 • 47 citations

Functional domains and phosphorylation of the orphan receptor Nur77

1993 • 47 citations

cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.

1995 • 45 citations

Small cortical thymocytes are subject to positive selection.

1994 • 38 citations

A genetic method for defining DNA-binding domains: application to the nuclear receptor NGFI-B.

1993 • 33 citations

Nerve stimulation and denervation induce differential patterns of immediate early gene mRNA expression in skeletal muscle

1993 • 32 citations

Activation of the Inducible Orphan Receptor Gene nur77 by Serum Growth Factors: Dissociation of Immediate-Early and Delayed-Early Responses

1993 • 20 citations