Checkpoints of dueling dimers foil death wishes

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye

1993 • 557 citations