The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition

Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state

1979 • 954 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Rapid separation of low molecular weight solutes from liposomes without dilution

1978 • 444 citations

Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells

1985 • 348 citations

Action of cyclosporine on mitochondrial calcium fluxes

1987 • 329 citations

The nature of the voltage-dependent conductance induced by alamethicin in black lipid membranes

1973 • 301 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel

1986 • 289 citations

A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii.

1979 • 278 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume.

1985 • 237 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Voltage-dependent channels in planar lipid bilayer membranes.

1981 • 225 citations

Facilitation of phospholipase A2 activity by mastoparans, a new class of mast cell degranulating peptides from wasp venom.

1983 • 224 citations

Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine.

1993 • 213 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation

1993 • 181 citations

Effects of phospholipase A2 inhibitors on ruthenium red-induced Ca2+ release from mitochondria.

1985 • 160 citations

Osmotic effects of polyethylene glycol

1988 • 147 citations

Electrophysiology of the inner mitochondrial membrane

1994 • 147 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

Pore size and properties of channels from mitochondria isolated fromNeurospora crassa

1980 • 136 citations

Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria

1989 • 122 citations

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

1991 • 114 citations

Magnesium-Ion Modulates the Sensitivity of the Mitochondrial Permeability Transition Pore to Cyclosporine-A and ADP

1994 • 110 citations

Kinetics of mitochondrial calcium transport. II. A kinetic description of the sodium-dependent calcium efflux mechanism of liver mitochondria and inhibition by ruthenium red and by tetraphenylphosphonium.

1986 • 106 citations

Modulation of inner mitochondrial membrane channel activity

1992 • 97 citations

Cyclosporin A protects hepatocytes subjected to high Ca²⁺ and oxidative stress

1992 • 96 citations

Mapping of the mastoparan-binding site on G proteins. Cross-linking of [125I-Tyr3,Cys11]mastoparan to Go

1991 • 86 citations

A new mast cell degranulating peptide homologous to mastoparan in the venom of Japanese hornet (Vespa xanthoptera).

1979 • 86 citations

Mastoparan, a wasp venom, stimulates insulin release by pancreatic islets through pertussis toxin sensitive GTP-binding protein

1989 • 82 citations

Communication between two globular domains of calmodulin in the presence of mastoparan or caldesmon fragment. Ca2+ binding and 1H NMR.

1987 • 82 citations

EGTA inhibits reverse uniport-dependent Ca2+ release from uncoupled mitochondria. Possible regulation of the Ca2+ uniporter by a Ca2+ binding site on the cytoplasmic side of the inner membrane.

1988 • 81 citations

Ca2+ transport properties of ionophores A23187, ionomycin, and 4-BrA23187 in a well defined model system

1994 • 77 citations

Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes.

1989 • 76 citations

Probing alamethicin channels with water-soluble polymers. Size-modulated osmotic action

1993 • 75 citations

Mastoparan stimulates exocytosis at a Ca(2+)-independent late site in stimulus-secretion coupling. Studies with the RINm5F beta-cell line.

1993 • 70 citations

Interaction of wasp venom mastoparan with biomembranes

1990 • 66 citations

Relationships between Ca2+ release, Ca2+ cycling, and Ca2+-mediated permeability changes in mitochondria.

1985 • 65 citations

Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure.

1985 • 62 citations

Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins

1990 • 62 citations

Dissociation of NAD(P)+-stimulated mitochondrial Ca2+ efflux from swelling and membrane damage

1984 • 52 citations

Mechanisms of mastoparan-stimulated surfactant secretion from isolated pulmonary alveolar type 2 cells.

1991 • 44 citations

Factors affecting solute entrapment in phospholipid vesicles prepared by the freeze-thaw extrusion method: a possible general method for improving the efficiency of entrapment

1990 • 42 citations

Mastoparan promotes exocytosis and increases intracellular cyclic AMP in human platelets. Evidence for the existence of a Ge-like mechanism of secretion

1992 • 38 citations

Effects of the wasp venom peptide, mastoparan, on a phosphoinositide-specific phospholipase C purified from rabbit brain membranes

1989 • 37 citations

Mastoparan increases membrane permeability in rat parotid cells independently of action on G-proteins

1991 • 35 citations

Selective Effects of Mastoparan Analogs: Separation of G-Protein-Directed and Membrane-Perturbing Activities

1993 • 35 citations

A new mast cell degranulating peptide, polistes mastoparan, in the venom of Polistes jadwigae

1980 • 28 citations

Effects of solute concentration on the entrapment of solutes in phospholipid vesicles prepared by freeze-thaw extrusion

1991 • 27 citations

A new mast cell degranulating peptide, mastoparan-M, in the venom of the hornet Vespa mandarinia

1981 • 21 citations

Identification of a GTP-binding protein in the contact sites between inner and outer mitochondrial membranes

1991 • 20 citations

Transient induction of the mitochondrial permeability transition by uncoupler plus a Ca2+-specific chelator

1991 • 19 citations

Generation of the mitochondrial permeability transition does not involve inhibition of lysophospholipid acylation. Acyl-coenzyme A:1-acyllysophospholipid acyltransferase activity is not found in rat liver mitochondria.

1991 • 18 citations

Membrane interactions of mastoparan analogues related to their differential effects on protein kinase C, Na,K‐ATPase and HL60 cells

1992 • 18 citations

Purification of a GTP-Binding Protein Localized in Mitochondria1

1993 • 9 citations

Mastoparan blockade of currents through Ca2+-activated K+ channels in bovine chromaffin cells

1992 • 6 citations

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