Kinetics of Fas-induced apoptosis in thymic organ culture.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Negative selection of lymphocytes

1994 • 810 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Positive selection of lymphocytes

1994 • 563 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

1980 • 331 citations

A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry

1994 • 319 citations

Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry

1994 • 226 citations

The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.

1993 • 210 citations

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

1995 • 197 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.

1988 • 142 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

Comparison of 35S- and digoxigenin-labeled RNA and oligonucleotide probes for in situ hybridization

1992 • 129 citations

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice.

1981 • 128 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

1993 • 82 citations

Defective maintenance of T cell tolerance to a superantigen in MRL-lpr/lpr mice.

1992 • 71 citations

Altered expression of self-reactive T cell receptor V beta regions in autoimmune mice.

1990 • 60 citations

The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes

1994 • 45 citations

Novel origin of lpr and gld cells and possible implications in autoimmunity

1990 • 29 citations

Origin and selection of peripheral CD4⁻CD8⁻ T cells bearing α/β T cell antigen receptors in autoimmune gld mice

1990 • 28 citations

Parallels in T lymphocyte development between lpr and normal mice

1994 • 15 citations