The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells

1985 • 1,237 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium.

1994 • 389 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces.

1994 • 322 citations

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

1995 • 267 citations

Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells

1994 • 248 citations

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

1994 • 214 citations

Pulsatile and steady flow induces c‐fos expression in human endothelial cells

1993 • 203 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Shear‐induced platelet‐derived growth factor gene expression in human endothelial cells is mediated by protein kinase C

1992 • 134 citations

Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter

1995 • 118 citations

Growth factors and cell proliferation

1992 • 77 citations

A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways

1995 • 55 citations