Signal Transduction, Mitotic Catastrophes, and Death in T‐Cell Development

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Programmed cell death in plants: A pathogen-triggered response activated coordinately with multiple defense functions

1994 • 670 citations

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 • 638 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

The thymic microenvironment

1993 • 459 citations

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

1993 • 449 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

The thymus selects the useful, neglects the useless and destroys the harmful

1989 • 378 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.

1990 • 372 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

Steroid production in the thymus: implications for thymocyte selection.

1994 • 351 citations

The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory.

1993 • 350 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

1002 Protein Phosphatases?

1992 • 330 citations

Activation events during thymic selection.

1992 • 326 citations

Regulation of apoptosis in the immune system

1994 • 321 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

Tumor necrosis factor receptor superfamily members and their ligands

1994 • 313 citations

Protein-tyrosine phosphatases: The other side of the coin

1989 • 308 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1992 • 281 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

1993 • 252 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

Sepsis-induced apoptosis of the thymocytes in mice.

1994 • 237 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.

1992 • 228 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

1993 • 221 citations

A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha

1994 • 220 citations

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

1994 • 210 citations

Cell death and the cell cycle: a relationship between transformation and neurodegeneration?

1993 • 205 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

Rescue of thymocytes and T cell hybridomas from glucocorticoid‐induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire

1991 • 199 citations

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

1994 • 198 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Cyclic regulation of CD45 isoform expression in a long term human CD4+CD45RA+ T cell line.

1991 • 186 citations

Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation.

1989 • 185 citations

The T-cell repertoire for antigen and MHC

1988 • 180 citations

Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.

1993 • 179 citations

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

1992 • 179 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Activation signals regulate heat shock transcription factor 1 in human B lymphocytes

1997 • 169 citations

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

1992 • 165 citations

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor.

1992 • 164 citations

Cytokines in T-cell development

1991 • 164 citations

Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells.

1994 • 162 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target.

1994 • 144 citations

Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.

1994 • 143 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

1989 • 140 citations

Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus

1990 • 140 citations

Regulation of TCR Signaling by CD45 Lacking Transmembrane and Extracellular Domains

1993 • 138 citations

Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis.

1993 • 137 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Death-defying acts: a meeting review on apoptosis.

1993 • 132 citations

Helper T-cell development in the absence of CD4-p56 Ick association

1993 • 132 citations

Retinoids are important cofactors in T cell activation.

1992 • 131 citations

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

1993 • 131 citations

Positive selection of CD4+ T cells mediated by MHC class ll-bearing stromal cell in the thymic cortex

1989 • 130 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.

1992 • 129 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Thymocyte apoptosis induced by elevated endogenous corticosterone levels

1994 • 126 citations

9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.

1993 • 124 citations

IL-10 inhibits apoptotic cell death in human T cells starved of IL-2

1993 • 123 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.

1991 • 118 citations

Hyporesponsiveness of “naive” (CD45RA⁺) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

1990 • 118 citations

Interleukin‐2 prevention of apoptosis in human neutrophils

1994 • 117 citations

T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death.

1994 • 117 citations

T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor

1991 • 113 citations

CD3‐mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin‐1, interleukin‐2, interferon‐γ and accessory cells

1993 • 113 citations

Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation.

1993 • 113 citations

Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45

1993 • 112 citations

Relationship between Apoptosis and the Cell Cycle in Lymphocytes: Roles of Protein Kinase C, Tyrosine Phosphorylation, and AP1

1993 • 111 citations

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.

1991 • 109 citations

Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 ⁺ CD8 ⁺ Cells

1992 • 109 citations

Definition of the thymic generative lineage by selective expression of high molecular weight isoforms of CD45 (T200)

1989 • 108 citations

Activation requirements for CD4+ T cells differing in CD45R expression.

1992 • 107 citations

Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.

1992 • 106 citations

Isoforms of the transmembrane tyrosine phosphatase cd45 differentially affect T cell recognition

1994 • 105 citations

Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas

1992 • 101 citations

The CD8 coreceptor revisited: One chain good, two chains better

1994 • 99 citations

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

1994 • 98 citations

The regulation and function of p21ras in T cells

1992 • 98 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5.

1994 • 96 citations

Genetic analysis of immune dysfunction in non‐obese diabetic (NOD) mice: Mapping of a susceptibility locus close to the Bcl‐2 gene correlates with increased resistance of NOD T cells to apoptosis induction

1994 • 92 citations

Positive selection of T lymphocytes on fibroblasts

1993 • 92 citations

Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells.

1994 • 92 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells

1994 • 88 citations

Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development.

1994 • 87 citations

Cytokine Gene Regulation: Regulatory cis-Elements and DNA Binding Factors Involved in the Interferon System

1992 • 87 citations

Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.

1991 • 86 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

1992 • 84 citations

Thymic selection: two pathways to life and two to death

1994 • 83 citations

Autoimmunity and apoptosis.

1994 • 83 citations

Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium

1989 • 83 citations

Killing of immature CD4⁺CD8⁺ thymocytes in vivo by anti‐CD3 or 5′‐(N‐ethyl)‐carboxamido‐adenosine is blocked by glucocorticoid receptor antagonist RU‐486

1993 • 79 citations

Interleukin-2, Autotolerance, and Autoimmunity

1991 • 79 citations

Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.

1994 • 77 citations

The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

1994 • 76 citations

Specific CD45 isoforms differentially regulate T cell receptor signaling.

1994 • 74 citations

In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands

1992 • 72 citations

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

1993 • 71 citations

Requirement for Tyrosine Kinase p56^lckfor Thymic Development of Transgenic γδ T Cells

1993 • 71 citations

Selective enrichment of T_h1 CD45RB^low CD4⁺ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis

1994 • 69 citations

Differential expression of APO‐1 on human thymocytes: Implications for negative selection?

1994 • 67 citations

Lymphocyte lineage commitment: Instruction versus selection

1993 • 67 citations

Thymic nurse cells are sites of thymocyte apoptosis.

1994 • 66 citations

Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations.

1992 • 65 citations

Proliferation and apoptosis of B220⁺ CD4⁻CD8⁻TCRαβ^intermediate T cells in the liver of normal adult mice: implication for Ipr pathogenesis

1994 • 65 citations

Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.

1994 • 64 citations

IL-12 influences intrathymic T cell development.

1994 • 64 citations

Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association

1993 • 63 citations

Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cell.

1993 • 62 citations

Thymic CD45 tyrosine phosphatase regulates apoptosis and MHC-restricted negative selection.

1994 • 62 citations

Interleukin 2 induces the expression of CD45RO and the memory phenotype by CD45RA+ peripheral blood lymphocytes.

1994 • 61 citations

Viral, worm and radical implications for apoptosis

1994 • 58 citations

Disruption of CD8‐dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1992 • 57 citations

CD3 antigen‐mediated calcium signals and protein kinase C activation are higher in CD45R0⁺ than in CD45RA⁺ human T lymphocyte subsets

1993 • 56 citations

The ligand for positive selection of T lymphocytes in the thymus

1994 • 56 citations

cAMP analogs prevent activation-induced apoptosis of T cell hybridomas.

1993 • 56 citations

Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo.

1994 • 55 citations

CD28-B7 interactions are not required for intrathymic clonal deletion

1993 • 53 citations

The effect of rapamycin on T cell development in mice

1994 • 51 citations

Nuclear events after activation of CD4+8+ thymocytes.

1990 • 50 citations

Rapid re‐expression of CD45RC on rat CD4 T cells in vitro correlates with a change in function

1993 • 47 citations

Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45.

1993 • 46 citations

The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes

1994 • 45 citations

CD45RA and CD45RBhigh expression induced by thymic selection events.

1992 • 45 citations

Negative regulation of apoptotic death in immature B cells by CD45

1994 • 45 citations

Developmental sequence of T200 antigen modifications in murine T cells.

1987 • 44 citations

CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis

1991 • 42 citations

Negative selection of thymocytes. A novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis.

1992 • 42 citations

Death and transfiguration of cortical thymocytes: a reconsideration

1990 • 42 citations

CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.

1992 • 41 citations

No Requirement for p56^lckin the Antigen-Stimulated Clonal Deletion of Thymocytes

1992 • 40 citations

The Role of p56^ICk and p59^fyn Tyrosine Kinases and CD45 Protein Tyrosine Phosphatase in T‐cell Development and Clonal Selection

1993 • 40 citations

Early mobilization of Ca2+ is not required for glucocorticoid-induced apoptosis in thymocytes.

1993 • 39 citations

Engagement of the CD45 molecule induces homotypic adhesion of human thymocytes through a LFA-1/ICAM-3-dependent pathway.

1994 • 38 citations

In vitro negative selection of αβ T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells

1993 • 38 citations

Immature thymocytes become sensitive to calcium-mediated apoptosis with the onset of CD8, CD4, and the T cell receptor expression: a role for bcl-2?

1993 • 34 citations

Ca²⁺ mobilization in physiologically stimulated single T cells gradually increases with peptide concentration (analog signaling)

1994 • 34 citations

CD45 modulates T cell receptor/CD3‐induced activation of human thymocytes via regulation of tyrosine phosphorylation

1992 • 34 citations

Up-regulation of c-myc induces the gene expression of the murine homologues of p34cdc2 and cyclin-dependent kinase-2 in T lymphocytes.

1994 • 32 citations

A thymic epithelial cell line induces both positive and negative selection in the thymus

1994 • 29 citations

CD4, CD8 and tyrosine kinases in thymic selection

1993 • 29 citations

Activation-induced cell death in proliferating T cells is associated with altered tyrosine phosphorylation of TCR/CD3 subunits.

1994 • 26 citations

TCR cross-linking induces CTL death via internal action of TNF.

1994 • 25 citations

Nature of the immunogenic moiety recognized by the human T cell proliferating in response to tetanus toxoid antigen

1981 • 24 citations

Ultrastructural analysis of thymic nurse cell epithelium

1994 • 22 citations

Prevention of TCR-mediated apoptosis by the elevation ofcAMP

1994 • 22 citations

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.

1993 • 21 citations

Thymic nurse cell lymphocytes react against self major histocompatibility complex

1992 • 20 citations

A positively selecting thymic epithelial cell line lacks costimulatory activity.

1994 • 20 citations

Glucocorticoids in malignant lymphoid cells: Gene regulation and the minimum receptor fragment for lysis

1992 • 19 citations

Role of CD4⁺CD45RA⁺ T cells in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse

1993 • 18 citations

Expression of high molecular weight isoforms of CD45 by mouse thymic progenitor cells

1990 • 18 citations

Interleukin‐7 regulates c‐myc expression in murine T cells and thymocytes: a role for tyrosine kinase(s) and calcium mobilization

1994 • 17 citations

Tyrosine kinase triggering in thymocytes undergoing positive selection

1992 • 15 citations

CD45RA is detected in all thymocyte subsets defined by CD4 and CD8 by using three-colour flow cytometry.

1990 • 14 citations

A positively selecting thymic epithelial cell line lacks costimulatory activity.

1994 • 14 citations

Differential activation of p21ras in CD45RA+ and CD45RO+ human T lymphocytes.

1994 • 10 citations

In situ analyses of in ovo graft‐vs.‐host reaction induced by thymic nurse cell lymphocytes

1993 • 10 citations

CD45RA antibodies split the CD3bright T cell subset

1991 • 8 citations

A novel CD45RA⁺CD4⁺ transient thymic subpopulation in MRL-lpr/lpr mice: its relation to non-proliferating CD4⁻CD8⁻CD45RA⁺ tumor cells

1993 • 8 citations

The variable occurrence of CD45RA on CD8⁺ thymocytes correlates with the presence of Mtv sequences; its expression on other thymocytes is rare

1992 • 3 citations