Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The mitochondrial permeability transition

1995 • 2,412 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1994 • 818 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

1992 • 561 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Liver cell necrosis: Cellular mechanisms and clinical implications

1995 • 393 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

1993 • 353 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes

1990 • 303 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

1995 • 288 citations

Active site mutants of human cyclophilin A separate peptidyl‐prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition

1992 • 287 citations

Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition.

1995 • 281 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1994 • 245 citations

Peptidylproline cis/trans isomerases

1995 • 235 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

1989 • 224 citations

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 • 217 citations

Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

1994 • 208 citations

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1992 • 189 citations

Identification and characterization of porins in Pseudomonas aeruginosa.

1991 • 188 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation

1993 • 181 citations

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

1994 • 162 citations

Conformational specificity of chymotrypsin toward proline-containing substrates

1984 • 157 citations

Mitochondrial calcium spiking: A transduction mechanism based on calcium‐induced permeability transition involved in cell calcium signalling

1994 • 149 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study

1995 • 128 citations

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

1991 • 114 citations

Prolyl isomerase requirement for the expression of functional homo-oligomeric ligand-gated ion channels

1994 • 108 citations

The presence of two classes of high‐affinity cyclosporin A binding sites in mitochondria

1990 • 104 citations

Modification of Cyclosporin A (CS): Generation of an enolate at the sarcosine residue and reactions with electrophiles

1993 • 84 citations

Calcium ion-dependent signalling and mitochondrial dysfunction: mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition

1995 • 84 citations

Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization.

1993 • 83 citations

The 3D structure of a cyclosporin analogue in water is nearly identical to the cyclophilin‐bound cyclosporin conformation

1994 • 78 citations

Evidence for the Involvement of a Membrane‐Associated Cyclosporin‐A‐Binding Protein in the Ca²⁺‐Activated Inner Membrane Pore of Heart Mitochondria

1995 • 53 citations

The Ca2+-induced permeability transition pore is involved in Ca2+-induced mitochondrial oscillations

1994 • 40 citations

Evidence for the Involvement of a Membrane-Associated Cyclosporin-A-Binding Protein in the Ca2+-Activated Inner Membrane Pore of Heart Mitochondria

1995 • 38 citations

pH Titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands

1994 • 37 citations

The nonspecific inner membrane pore of liver mitochondria: Modulation of cyclosporin sensitivity by ADP at carboxyatractyloside-sensitive and insensitive sites

1991 • 37 citations

An ADP‐sensitive cyclosporin‐A‐binding protein in rat liver mitochondria

1994 • 36 citations

Improved Binding Affinity for Cyclophilin A by a Cyclosporin Derivative Singly Modified at Its Effector Domain

1994 • 30 citations

Interaction of cyclosporin A and two cyclosporin analogs with cyclophilin: relationship between structure and binding

1994 • 22 citations

The X-ray structure of (MeBm₂t)¹-cyclosporin complexed with cyclophilin A provides an explanation for its anomalously high immunosuppressive activity

1994 • 19 citations

Flow-force relationships during energy transfer between mitochondrial proton pumps

1991 • 10 citations