Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

The mitochondrial permeability transition

1995 • 2,412 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

The biochemistry of programmed cell death

1995 • 997 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

1994 • 845 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation

1991 • 454 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

A Specific and Sensitive Assay for Disulfides

1968 • 446 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 442 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Regulation of Ca ²⁺ release from mitochondria by the oxidation-reduction state of pyridine nucleotides

1978 • 364 citations

Physiological roles of nicotinamide nucleotide transhydrogenase

1988 • 348 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

Action of cyclosporine on mitochondrial calcium fluxes

1987 • 329 citations

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

1993 • 315 citations

On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

1993 • 295 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2+ by mitochondria.

1980 • 288 citations

Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition.

1995 • 281 citations

The mitochondrial megachannel is the permeability transition pore

1992 • 262 citations

Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I)

1994 • 236 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

1989 • 224 citations

The role of glutathione in the retention of Ca2+ by liver mitochondria.

1984 • 223 citations

Mitochondrial channel activity studied by patch-clamping mitoplasts

1989 • 206 citations

Hydroperoxides can modulate the redox state of pyridine nucleotides and the calcium balance in rat liver mitochondria

1979 • 205 citations

The mitochondrial permeability transition pore may comprise VDAC molecules

1993 • 172 citations

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

1980 • 157 citations

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide

1995 • 146 citations

An Escherichia coli homologue of eukaryotic potassium channel proteins.

1994 • 130 citations

Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study

1995 • 128 citations

Beta-NADH decreases the permeability of the mitochondrial outer membrane to ADP by a factor of 6.

1994 • 124 citations

Intrinsic uncoupling of mitochondrial proton pumps. 1. Nonohmic conductance cannot account for the nonlinear dependence of static head respiration on .DELTA.~.mu.H

1986 • 114 citations

Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status

1995 • 109 citations

The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides

1980 • 94 citations

Permeability of inner mitochondrial membrane and oxidative stress

1988 • 94 citations

Selective inhibition of the mitochondrial permeability transition pore at the oxidation‐reduction sensitive dithiol by monobromobimane

1995 • 85 citations

Dissociation between mitochondria calcium ion release and pyridine nucleotide oxidation.

1980 • 46 citations

Glutathione-gated K+ channels of Escherichia coli carry out K+ efflux controlled by the redox state of the cell

1990 • 38 citations

Phenylarsine oxide stimulates pyridine nucleotide-linked Ca2+ release from rat liver mitochondria

1994 • 26 citations

Ca²⁺‐triggered membrane permeability transition in deenergized mitochondria from rat liver

1995 • 23 citations

Ca2+-Sensitive reduction of 5,5′-dithiobis-(2-nitrobenzoic acid) by rat liver mitochondria

1992 • 13 citations