T-cell apoptosis detected in situ during positive and negative selection in the thymus

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Germinal Centers

1994 • 1,680 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Selective Events in T Cell Development

1994 • 486 citations

Ionizing Radiation and the Immune Response

1976 • 435 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets.

1983 • 231 citations

In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.

1991 • 199 citations

Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells

1990 • 193 citations

A novel MHC class II epitope expressed in thymic medulla but not cortex

1989 • 175 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

Two subsets of epithelial cells in the thymic medulla.

1992 • 116 citations

Ultrastructure of the rat thymus: The micro-environment of T-lymphocyte maturation

1981 • 97 citations

The Thymus

1966 • 82 citations

Recognition and Regulation in Cell-Mediated Immunity

1985 • 79 citations

Tolerance to Self Antigens Shapes the T‐Cell Repertoire

1989 • 62 citations

Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells.

1992 • 54 citations

Mucosal Immunity: IgA and Polymorphonuclear Neutrophils

1986 • 47 citations

The Immune System of Mice Lacking Conventional MHC Class II Molecules

1993 • 41 citations

Ciba Foundation Symposium ‐ The Thymus: Experimental and Clinical Studies

1966 • 37 citations