Crk is required for apoptosis in Xenopus egg extracts

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Protein modules and signalling networks

1995 • 2,447 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Ovarian Follicle Atresia: A Hormonally Controlled Apoptotic Process*

1994 • 728 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

INVOLVEMENT OF APOPTOSIS IN OVARIAN FOLLICULAR ATRESIA AND POSTOVULATORY REGRESSION

1991 • 650 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

c-Abl kinase regulates the protein binding activity of c-Crk.

1994 • 362 citations

The cell-death machine

1996 • 351 citations

Structural and Signaling Requirements for BCR-ABL-Mediated Transformation and Inhibition of Apoptosis

1995 • 282 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Two species of human CRK cDNA encode proteins with distinct biological activities.

1992 • 269 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Cell death in health and disease: the biology and regulation of apoptosis

1995 • 245 citations

Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins

1995 • 233 citations

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1994 • 211 citations

Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

1994 • 205 citations

SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl

1994 • 189 citations

Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells

1994 • 187 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

The product of the cellular crk gene consists primarily of SH2 and SH3 regions.

1992 • 147 citations

Regulation of the Fas Apoptotic Cell Death Pathway by Abl

1995 • 146 citations

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

1995 • 142 citations

Direct demonstration of an intramolecular SH2—phosphotyrosine interaction in the Crk protein

1995 • 130 citations

Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation

1990 • 128 citations

Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosis

1995 • 123 citations

Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line

1994 • 120 citations

The Product of the cbl Oncogene Forms Stable Complexes In Vivo with Endogenous Crk in a Tyrosine Phosphorylation-Dependent Manner

1996 • 117 citations

Two Species of Human CRK cDNA Encode Proteins with Distinct Biological Activities

1992 • 58 citations

Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors.

1994 • 57 citations

CRK Protein Binds to Two Guanine Nucleotide-Releasing Proteins for the Ras Family and Modulates Nerve Growth Factor-Induced Activation of Ras in PC12 Cells

1994 • 50 citations

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

1996 • 49 citations

The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase.

1994 • 45 citations

v-Abl-mediated Apoptotic Suppression Is Associated with SHC Phosphorylation without Concomitant Mitogen-activated Protein Kinase Activation

1995 • 45 citations

Lineage-specific Induction of B Cell Apoptosis and Altered Signal Transduction by the Phosphotyrosine Phosphatase Inhibitor Bis(maltolato)oxovanadium(IV)

1995 • 36 citations

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl- 2 suppressible mechanism

1995 • 11 citations