Thymocyte apoptosis induced by p53-dependent and independent pathways

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12.

1979 • 238 citations

The mouse Pgk-1 gene promoter contains an upstream activator sequence

1991 • 200 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Analysis of the gene coding for the murine cellular tumour antigen p53.

1984 • 182 citations

Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression.

1991 • 137 citations

Antiproliferative Activity of a Pregnancy Recognition Hormone, Ovine Trophoblast Protein-1

1991 • 132 citations

Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing

1983 • 105 citations

The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes

1992 • 95 citations

Regulation of T lymphocyte apoptosis. Signals for the antagonism between activation- and glucocorticoid-induced death.

1991 • 91 citations

A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor δ-chain-encoding gene

1991 • 36 citations

Effect of Gamma-irradiation on DNA-dependent RNA Polymerase Activity in Rat Thymus Cells

1982 • 7 citations