Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

Liver cell necrosis: Cellular mechanisms and clinical implications

1995 • 393 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

1992 • 343 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids

1993 • 281 citations

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.

1994 • 270 citations

Apoptosis and hepatobiliary disease

1995 • 268 citations

Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER

1996 • 262 citations

Ceramide: A stress signal and mediator of growth suppression and apoptosis

1995 • 233 citations

Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.

1995 • 231 citations

Sphingolipid metabolism in cultured fibroblasts: microscopic and biochemical studies employing a fluorescent ceramide analogue.

1983 • 194 citations

The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver

1993 • 180 citations

Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.

1992 • 121 citations

pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytes

1993 • 100 citations

Does endotoxin stimulate cells by mimicking ceramide?

1995 • 93 citations

Induction of the mitochondrial permeability transition by protease activity in rats: A mechanism of hepatocyte necrosis

1996 • 88 citations

Mitochondrial dysfunction during anoxia/reoxygenation injury of liver sinusoidal endothelial cells

1994 • 75 citations

Sphingosine: a mediator of acute renal tubular injury and subsequent cytoresistance.

1995 • 59 citations

Ruthenium red delays the onset of cell death during oxidative stress of rat hepatocytes

1992 • 38 citations

A cascade of degradative hydrolase activity contributes to hepatocyte necrosis during anoxia

1996 • 33 citations