Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Chapter 30 Cell Cycle Extracts

1991 • 953 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA

1987 • 550 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Biochemical Identification of Apoptosis (Programmed Cell Death) in Granulosa Cells: Evidence for a Potential Mechanism Underlying Follicular Atresia*

1991 • 510 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis

1989 • 438 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

1992 • 336 citations

Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.

1993 • 309 citations

Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase

1993 • 264 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Structure and Function of the Nuclear Pore Complex

1992 • 237 citations

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1994 • 233 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin.

1991 • 222 citations

In vitro transport of a fluorescent nuclear protein and exclusion of non-nuclear proteins.

1986 • 211 citations

Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency.

1994 • 205 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

1994 • 190 citations

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1993 • 185 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

1993 • 150 citations

A trypsin-sensitive receptor on membrane vesicles is required for nuclear envelope formation in vitro.

1988 • 148 citations

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

1990 • 147 citations

Chapter 31 Egg Extracts for Nuclear Import and Nuclear Assembly Reactions

1991 • 143 citations

Spontaneous assembly of pore complex-containing membranes ("annulate lamellae") in Xenopus egg extract in the absence of chromatin.

1991 • 133 citations

Chapter 4 Oogenesis and Oocyte Isolation

1991 • 130 citations

GTP hydrolysis is required for vesicle fusion during nuclear envelope assembly in vitro.

1992 • 119 citations

A procedure for the rapid preparation of mitochondria from rat liver

1982 • 106 citations

Cloning of a Grb2 Isoform with Apoptotic Properties

1994 • 91 citations

Mitochondrial calcium release induced by prooxidants

1993 • 86 citations

Determination of initiation of DNA replication before and after nuclear formation in Xenopus egg cell free extracts.

1993 • 78 citations

Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin

1993 • 75 citations

‘Pore’ formation is not required for the hydroperoxide-induced Ca2+ release from rat liver mitochondria

1992 • 65 citations

Internucleosomal Deoxyribonucleic Acid Cleavage Activity in Apoptotic Thymocytes: Detection and Endocrine Regulation*

1991 • 61 citations

[38] Purification and assay of CD45: An integral membrane protein-tyrosine phosphatase

1991 • 26 citations

Oncogenic Ras blocks cell cycle progression and inhibits p34cdc2 kinase in activated Xenopus egg extracts.

1994 • 16 citations

A strategy for generating monoclonal antibodies against recombinant baculovirus-produced proteins: Application to the Bcl-2 oncoprotein

1992 • 16 citations