Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

1981 • 1,366 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1986 • 1,150 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Multiple Point Mutations Affecting the Simian Virus 40 Enhancer

1983 • 883 citations

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

1986 • 834 citations

Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.

1984 • 776 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

1988 • 689 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

1987 • 631 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Transcriptional control in the production of liver-specific mRNAs

1981 • 593 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

1986 • 548 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene

1987 • 516 citations

Structure of the human immune interferon gene

1982 • 510 citations

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

1987 • 509 citations

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

1988 • 502 citations

A human T cell-specific molecule is a member of a new gene family.

1988 • 500 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Characterization of junD: a new member of the jun proto-oncogene family.

1989 • 492 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.

1983 • 446 citations

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

1988 • 435 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.

1986 • 335 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes

1987 • 321 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro.

1988 • 309 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

The SV40 enhancer is composed of multiple functional elements that can compensate for one another

1986 • 293 citations

Sequential expression of genes involved in human T lymphocyte growth and differentiation.

1985 • 291 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.

1986 • 285 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding

1984 • 281 citations

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

1985 • 280 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently with two separate octamer-related sequences within the SV40 enhancer.

1987 • 263 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

Cloning of a cDNA for a T Cell-Specific Serine Protease from a Cytotoxic T Lymphocyte

1986 • 247 citations

Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1

1989 • 247 citations

Novel Serine Proteases Encoded by Two Cytotoxic T Lymphocyte-Specific Genes

1986 • 246 citations

Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.

1984 • 239 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

1988 • 234 citations

Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts

1986 • 209 citations

Insulin-like growth factor I and insulin rapidly increase casein kinase II activity in BALB/c 3T3 fibroblasts.

1988 • 207 citations

Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes.

1985 • 203 citations

Regulation of bcl-2 Proto-Oncogene Expression During Normal Human Lymphocyte Proliferation

1987 • 202 citations

Two regulatory elements for immunoglobulin kappa light chain gene expression.

1984 • 197 citations

Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements.

1987 • 197 citations

OBP100 binds remarkably degenerate octamer motifs through specific interactions with flanking sequences.

1988 • 184 citations

Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay

1987 • 176 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.

1986 • 171 citations

Stable expression of the tax gene of type I human T-cell leukemia virus in human T cells activates specific cellular genes involved in growth.

1988 • 169 citations

Sequence-specific interactions between cellular DNA-binding proteins and the adenovirus origin of DNA replication.

1987 • 169 citations

The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

1987 • 164 citations

Phosphorylation of eukaryotic DNA-dependent RNA polymerase. Identification of calf thymus RNA polymerase subunits phosphorylated by two purified protein kinases, correlation with in vivo sites of phosphorylation in HeLa cell RNA polymerase II.

1981 • 159 citations

Lymphocyte activation antigens. I. A monoclonal antibody, anti-Act I, defines a new late lymphocyte activation antigen.

1984 • 156 citations

Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.

1989 • 152 citations

Complexity of the primary genetic response to mitogenic activation of human T cells.

1989 • 149 citations

Potential basis for regulation of the coordinately expressed fibrinogen genes: homology in the 5' flanking regions.

1984 • 148 citations

Hormonal regulation of the bovine prolactin promoter in rat pituitary tumor cells.

1985 • 147 citations

Two functionally different regions in Fos are required for the sequence-specific DNA interaction of the Fos/Jun protein complex

1989 • 147 citations

An immunoglobulin promoter displays cell-type specificity independently of the enhancer

1985 • 144 citations

Structure of the chromosomal gene for murine interleukin 3.

1985 • 129 citations

Functional cooperativity between protein molecules bound at two distinct sequence elements of the immunoglobulin heavy-chain promoter

1989 • 128 citations

The effects of dexamethasone on in vitro collagen gene expression.

1987 • 128 citations

Functional characterization of an antigen involved in an early step of T-cell activation.

1987 • 120 citations

The isolation and sequence of a novel gene from a human functional T cell line.

1987 • 120 citations

Cell-type preference of immunoglobulin kappa and lambda gene promoters.

1985 • 118 citations

Transferrin synthesis by inducer T lymphocytes.

1986 • 107 citations

In vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter.

1987 • 100 citations

Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities

1987 • 89 citations

Cloning and characterization of a novel T cell activation gene.

1987 • 88 citations

CD45-protein tyrosine phosphatase cross-linking inhibits T cell receptor CD3-mediated activation in human T cells.

1989 • 85 citations

Transcriptional and posttranscriptional control of c-myc gene expression in WEHI 231 cells.

1986 • 84 citations

Regulation of expression of the human interferon gamma gene.

1985 • 84 citations

Activation of T lymphocytes results in an increase inH-2-encoded neuraminidase

1985 • 82 citations

Increased efficiency of translation of ornithine decarboxylase mRNA in mitogen‐activated lymphocytes

1987 • 79 citations

Molecular events involved in regulating human interferon-gamma gene expression during T cell activation.

1987 • 78 citations

Expression of a 26,000-dalton glycoprotein on activated human T cells

1981 • 70 citations

Induction of interleukin 2 receptor (TAC) by tumor necrosis factor in YT cells.

1987 • 69 citations

CTLA-1 and CTLA-3 serine esterase transcripts are detected mostly in cytotoxic T cells, but not only and not always.

1987 • 59 citations

Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation.

1989 • 54 citations

Interleukin secretion by B cell lines and splenic B cells stimulated with calcium ionophore and phorbol ester.

1987 • 54 citations

A novel cell surface antigen (T305) found in increased frequency on acute leukemia cells and in autoimmune disease states.

1983 • 51 citations

Hormonally mediated negative regulation of human pro-opiomelanocortin gene expression after transfection into mouse L cells.

1985 • 50 citations

Reaction of T lymphocytes with anti-T3 induces translocation of C-kinase activity to the membrane and specific substrate phosphorylation.

1987 • 47 citations

Cell matrix adhesion-related proteins VLA-1 and VLA-2: regulation of expression on T cells.

1987 • 44 citations

Triggering of the lethal hit in human cytotoxic T lymphocytes: a functional role for a 103‐kDa T cell‐ specific activation antigen

1986 • 37 citations

Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.

1988 • 34 citations

A late-differentiation antigen associated with the helper inducer function of human T cells

1985 • 28 citations

Different Early-Signaling Pathways Coupled to Transcriptional and Posttranscriptional Regulation of Gene Expression during Mitogenic Activation of T Lymphocytes

1987 • 21 citations

Early events in lymphocyte activation as defined by three new monoclonal antibodies.

1986 • 15 citations

MALA-1: a surface antigen expressed on activated murine T and B lymphocytes.

1984 • 14 citations

Characterization of human genomic DNA sequences homologous to the interleukin 2 cDNA

1986 • 3 citations