The Role of p56^ICk and p59^fyn Tyrosine Kinases and CD45 Protein Tyrosine Phosphatase in T‐cell Development and Clonal Selection

Adhesion receptors of the immune system

1990 • 6,585 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

1988 • 930 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Antigen Receptors on B Lymphocytes

1992 • 509 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

1988 • 435 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

1990 • 432 citations

Demonstration that the leukocyte common antigen (CD45) is a protein tyrosine phosphatase

1988 • 425 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Constitutive activation of Src family kinases in mouse embryos that lack Csk

1993 • 401 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

1993 • 394 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Control of transcription factors by signal transduction pathways: the beginning of the end

1992 • 360 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1990 • 346 citations

1002 Protein Phosphatases?

1992 • 330 citations

Activation events during thymic selection.

1992 • 326 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

Protein-tyrosine phosphatases: The other side of the coin

1989 • 308 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1.

1992 • 286 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45

1991 • 269 citations

Phosphatidylinositol membrane anchors and T-cell activation

1991 • 263 citations

Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.

1990 • 259 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

Mechanisms of Alternative Pre-mRNA Splicing

1991 • 257 citations

CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.

1993 • 243 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Functional analysis of T lymphocyte subsets in antiviral host defense.

1987 • 237 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

Inositol phospholipid-specific phospholipase C: interaction of the γ isoform with tyrosine kinase

1991 • 233 citations

Intercellular Communication and Cell-Cell Adhesio n

1992 • 230 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin.

1990 • 225 citations

Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.

1993 • 222 citations

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

1993 • 221 citations

Self-reactive γδ T cells are eliminated in the thymus

1990 • 221 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

Multichain immune recognition receptors: similarities in structure and signaling pathways

1992 • 210 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

1991 • 205 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

Cyclic regulation of CD45 isoform expression in a long term human CD4+CD45RA+ T cell line.

1991 • 186 citations

Changes in CD45 isoform expression accompany antigen-induced murine T-cell activation.

1989 • 185 citations

Inability of CD8α′polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo

1989 • 183 citations

CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

1992 • 179 citations

Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.

1993 • 179 citations

Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.

1988 • 176 citations

CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor

1990 • 174 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

Activation signals regulate heat shock transcription factor 1 in human B lymphocytes

1997 • 169 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck.

1990 • 142 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

Tyrosyl Phosphorylation and Activation of MAP Kinases by p56^lck

1992 • 140 citations

The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

1989 • 140 citations

Association of CD2 and CD45 on human T lymphocytes

1990 • 139 citations

Regulation of TCR Signaling by CD45 Lacking Transmembrane and Extracellular Domains

1993 • 138 citations

Transactivation of c-fos and β-actin genes by raf as a step in early response to transmembrane signals

1990 • 138 citations

VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation.

1992 • 132 citations

Positive selection of CD4+ T cells mediated by MHC class ll-bearing stromal cell in the thymic cortex

1989 • 130 citations

Protein kinase C activation by phorbol esters: do cysteine-rich regions and pseudosubstrate motifs play a role?

1991 • 124 citations

Hyporesponsiveness of “naive” (CD45RA⁺) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

1990 • 118 citations

Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.

1991 • 118 citations

T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor

1991 • 113 citations

Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45

1993 • 112 citations

Activators of Protein Kinase C Induce Dissociation of CD4, But Not CD8, from p56 ^lck

1989 • 111 citations

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.

1991 • 109 citations

Definition of the thymic generative lineage by selective expression of high molecular weight isoforms of CD45 (T200)

1989 • 108 citations

Activation requirements for CD4+ T cells differing in CD45R expression.

1992 • 107 citations

Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8

1993 • 101 citations

The regulation and function of p21ras in T cells

1992 • 98 citations

p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation.

1992 • 94 citations

A human T cell‐specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein‐tyrosine kinases

1986 • 92 citations

Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity.

1991 • 92 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

Isoform‐specific associations of CD45 with accessory molecules in human T lymphocytes

1992 • 84 citations

Analysis of recent thymic emigrants with subse- and maturity-related markers

1990 • 83 citations

Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells.

1992 • 77 citations

Requirement for Tyrosine Kinase p56^lckfor Thymic Development of Transgenic γδ T Cells

1993 • 71 citations

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

1993 • 71 citations

The tyrosine kinase activity of p56^lck is increased in human T cells activated via CD2

1991 • 67 citations

Lymphocyte lineage commitment: Instruction versus selection

1993 • 67 citations

Surface immunoglobulin crosslinking activates a tyrosine kinase pathway in B cells that is independent of protein kinase C.

1991 • 65 citations

Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations.

1992 • 65 citations

A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions.

1990 • 64 citations

Disruption of CD8‐dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

1992 • 57 citations

CD3 antigen‐mediated calcium signals and protein kinase C activation are higher in CD45R0⁺ than in CD45RA⁺ human T lymphocyte subsets

1993 • 56 citations

The role of CD45 in T-cell activation — resolving the paradoxes?

1992 • 49 citations

Rapid re‐expression of CD45RC on rat CD4 T cells in vitro correlates with a change in function

1993 • 47 citations

CD45RA and CD45RBhigh expression induced by thymic selection events.

1992 • 45 citations

Developmental sequence of T200 antigen modifications in murine T cells.

1987 • 44 citations

CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis

1991 • 42 citations

No Requirement for p56^lckin the Antigen-Stimulated Clonal Deletion of Thymocytes

1992 • 40 citations

Subsets of thymopoietic rat thymocytes defined by expression of the CD2 antigen and the MRC OX‐22 determinant of the leukocyte‐common an

1989 • 38 citations

Sequence Conservation in Potential Regulatory Regions of the Mouse and Human Leukocyte Common Antigen Gene

1989 • 35 citations

Integrity of the Exon 6 Sequence Is Essential for Tissue-Specific Alternative Splicing of Human Leukocyte Common Antigen Pre-mRNA

1989 • 34 citations

CD45 modulates T cell receptor/CD3‐induced activation of human thymocytes via regulation of tyrosine phosphorylation

1992 • 34 citations

Regulation of alternative splicing in the generation of isoforms of the mouse Ly-5 (CD45) glycoprotein.

1990 • 29 citations

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.

1993 • 21 citations

Comparison of the Sensitivity of in Vivo and in Vitro Assays for Detection of Antiviral Cytotoxic T Cell Activity

1993 • 20 citations

Expression of high molecular weight isoforms of CD45 by mouse thymic progenitor cells

1990 • 18 citations

Tyrosine kinase triggering in thymocytes undergoing positive selection

1992 • 15 citations

Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA.

1989 • 12 citations

CD45RA antibodies split the CD3bright T cell subset

1991 • 8 citations

The variable occurrence of CD45RA on CD8⁺ thymocytes correlates with the presence of Mtv sequences; its expression on other thymocytes is rare

1992 • 3 citations