Ceramide: a signal for apoptosis or mitogenesis?

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Interleukin l and T Cell Activation

1982 • 622 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Sphingomyelins in bilayers and biological membranes

1980 • 367 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Sphingomyelin and derivatives as cellular signals

1991 • 275 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs

1991 • 210 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1994 • 198 citations

CD28 signals through acidic sphingomyelinase.

1995 • 194 citations

Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

1993 • 179 citations

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

1994 • 174 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

Direct Stimulation of Vav Guanine Nucleotide Exchange Activity for Ras by Phorbol Esters and Diglycerides

1994 • 132 citations

Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.

1993 • 124 citations

Phosphorylation of Ceramide by Diglyceride Kinase Preparations from Escherichia coli

1973 • 86 citations

Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.

1994 • 75 citations

Human acid sphingomyelinase

2003 • 57 citations

Signaling mechanisms in T cells.

1991 • 53 citations

Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells

1994 • 39 citations

Second Messengers: Sphingolipid signalling

1994 • 34 citations

Production and Assay of Interleukin-1 (IL-1)

1982 • 17 citations