Signal transduction through lipid second messengers

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

1994 • 715 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin

1995 • 537 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

1995 • 469 citations

An update of the enzymology and regulation of sphingomyelin metabolism

1990 • 460 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1994 • 273 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

Signal transduction and membrane traffic: The PITP/phosphoinositide connection

1995 • 261 citations

Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.

1994 • 253 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.

1990 • 230 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)

1995 • 209 citations

Phospholipase D signaling is essential for meiosis.

1995 • 208 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

An essential role for phosphatidylinositol transfer protein in phospholipase C-Mediated inositol lipid signaling

1993 • 205 citations

Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.

1995 • 197 citations

GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipids.

1994 • 192 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L.

1994 • 185 citations

Requirement for Phosphatidylinositol Transfer Protein in Epidermal Growth Factor Signaling

1995 • 180 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

1994 • 174 citations

Ceramide: a signal for apoptosis or mitogenesis?

1995 • 173 citations

Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.

1994 • 169 citations

ARF signaling: A potential role for phospholipase D in membrane traffic

1993 • 161 citations

Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate

1995 • 161 citations

Lysophosphatidic acid possesses dual action in cellproliferation.

1994 • 151 citations

Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.

1994 • 147 citations

Partial Purification and Characterization of Arf-sensitive Phospholipase D from Porcine Brain

1995 • 143 citations

Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells

1994 • 142 citations

Purification and characterization of phosphatidylcholine phospholipase D from pig lung.

1994 • 137 citations

Direct Stimulation of Vav Guanine Nucleotide Exchange Activity for Ras by Phorbol Esters and Diglycerides

1994 • 132 citations

Resolved Phospholipase D Activity Is Modulated by Cytosolic Factors Other than Arf

1995 • 129 citations

Ceramide and the induction of apoptosis.

1996 • 128 citations

Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed.

1993 • 124 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.

1994 • 113 citations

Processing of human acid sphingomyelinase in normal and I-cell fibroblasts.

1994 • 90 citations

Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Ceramide 1‐Phosphate Phosphatase Activity in Brain

1993 • 80 citations

Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane.

1993 • 78 citations

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.

1994 • 76 citations

Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase

1994 • 68 citations

Characterization of a novel intracellular sphingolipid-gated Ca(2+)-permeable channel from rat basophilic leukemia cells.

1994 • 66 citations

Intracellular signalling mediated by protein-tyrosine kinases: Networking through phospholipid metabolism

1993 • 49 citations

Augustus De Morgan

1871 • 7 citations