A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Septic shock: pathogenesis

1991 • 743 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.

1992 • 402 citations

Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.

1991 • 318 citations

Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.

1993 • 302 citations

Internal protein sequence analysis: Enzymatic digestion for less than 10 μg of protein bound to polyvinylidene difluoride or nitrocellulose membranes

1992 • 290 citations

Shared Actions of Endotoxin and Taxol on TNF Receptors and TNF release

1990 • 288 citations

Recognition of endotoxin by cells leading to transmembrane signaling

1994 • 241 citations

Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.

1993 • 211 citations

Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin.

1993 • 183 citations

Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages.

1992 • 180 citations

The role of cytokine mediators in septic shock.

1990 • 172 citations

Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms

1993 • 159 citations

Heterogeneous expression of four MAP kinase isoforms in human tissues

1992 • 143 citations

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

1990 • 110 citations

Enhancement of murine macrophage binding of and response to bacterial lipopolysaccharide (LPS) by LPS-binding protein

1992 • 53 citations

[9] Isolation of tyrosine-phosphorylated proteins and generation of monoclonal antibodies

1991 • 13 citations