Interleukin-2, Autotolerance, and Autoimmunity

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

ACUTE RESPIRATORY DISTRESS IN ADULTS

1967 • 4,096 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Van Damme A.

1986 • 3,477 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Cyclosporine

1989 • 1,340 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON

1987 • 1,062 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

1988 • 793 citations

Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.

1989 • 785 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

1990 • 643 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

1990 • 610 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

IgG1 plasmacytosis in interleukin 6 transgenic mice.

1989 • 597 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Hypertension and hyperuricaemia

1965 • 496 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

High-Dose Recombinant Interleukin 2 in the Treatment of Patients With Disseminated Cancer

1986 • 459 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

The IL-2 Receptor β Chain (p70): Role in Mediating Signals for LAK, NK, and Proliferative Activities

1987 • 444 citations

CYCLOSPORIN INCREASES THE RATE AND LENGTH OF REMISSIONS IN INSULIN-DEPENDENT DIABETES OF RECENT ONSET

1986 • 443 citations

Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.

1990 • 436 citations

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

1988 • 432 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

1982 • 421 citations

Lines of T Lymphocytes Induce or Vaccinate Against Autoimmune Arthritis

1983 • 418 citations

Involvement of IL-6 in mesangial proliferative glomerulonephritis.

1989 • 415 citations

T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis.

1989 • 402 citations

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4

1989 • 372 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.

1987 • 363 citations

The fate of interleukin-2 after in vivo administration.

1983 • 358 citations

T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat.

1986 • 358 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Effects of Cyclosporine A on T Cell Development and Clonal Deletion

1988 • 354 citations

Interleukin 2 Regulates Expression of Its Receptor and Synthesis of Gamma Interferon by Human T Lymphocytes

1984 • 350 citations

The released interleukin 2 receptor binds interleukin 2 efficiently.

1986 • 348 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

1990 • 338 citations

Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice

1989 • 335 citations

Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.

1988 • 335 citations

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

1981 • 334 citations

Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

1980 • 331 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis.

1988 • 321 citations

Hypothyroidism after Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells

1988 • 321 citations

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

1990 • 312 citations

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.

1984 • 302 citations

Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes

1987 • 301 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.

1983 • 285 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.

1990 • 283 citations

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

1988 • 281 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 inhibition.

1988 • 274 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

Genetic susceptibility to post-thymectomy autoimmune diseases in mice

1981 • 265 citations

Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury.

1989 • 255 citations

T Lymphocytes in Collagen II‐Induced Arthritis in Mice

1985 • 253 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

1989 • 246 citations

Calcium and T lymphocyte activation

1989 • 246 citations

The Interleukin 2 Receptor

1989 • 244 citations

Three-Dimensional Structure of Interleukin-2

1987 • 242 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene.

1981 • 237 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

Lymphokines and aging: interleukin-2 production and activity in aged animals.

1981 • 234 citations

Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor.

1987 • 234 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

Pleiotropy and redundancy: T cell-derived lymphokines in the immune response

1989 • 228 citations

Thyroid Autoimmunity in Patients on Long Term Therapy with Leukocyte-Derived Interferon*

1986 • 227 citations

Autoimmune human T lymphocytes specific for acetylcholine receptor

1984 • 224 citations

Developmental Biology of T Cell Receptors

1989 • 223 citations

T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice.

1983 • 221 citations

In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp‐lpr/lpr mouse

1990 • 219 citations

Prevention of vaccinia virus infection in imiminodeficient mice by vector-directed IL-2 expression

1987 • 216 citations

Unique structure of murine interleukin-2 as deduced from cloned cDNAs

1985 • 205 citations

IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans.

1989 • 201 citations

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

1988 • 199 citations

Interleukin 2 deficiency is a common feature of autoimmune mice.

1981 • 198 citations

Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection

1987 • 198 citations

Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease.

1989 • 197 citations

INDUCTION OF GRAFT-VERSUS-HOST DISEASE AFTER AUTOLOGOUS BONE MARROW TRANSPLANTATION

1989 • 196 citations

Immunologic and Genetic Factors in Autoimmune Diseases

1984 • 195 citations

Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy.

1990 • 194 citations

Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.

1985 • 194 citations

T‐Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State

1987 • 190 citations

Interleukin-2 Administration Causes Reversible Hemodynamic Changes and Left Ventricular Dysfunction Similar to Those Seen in Septic Shock

1988 • 186 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses

1986 • 182 citations

Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.

1989 • 180 citations

LOW-DOSE INTERLEUKIN-2 INDUCES SYSTEMIC IMMUNE RESPONSES AGAINST HBsAg IN IMMUNODEFICIENT NON-RESPONDERS TO HEPATITIS B VACCINATION

1989 • 174 citations

Constitutive production of interleukin‐6 and immunologic features in cardiac myxomas

1990 • 172 citations

In vitro production of IL 1β, IL 1α, TNF and IL 2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation

1989 • 172 citations

Soluble interleukin‐2 receptors in systemic lupus erythematosus

1988 • 170 citations

Chronic therapy with recombinant tumor necrosis factor-α in autoimmune NZB/NZW F1 mice

1989 • 169 citations

Modulation of antibody-mediated glomerular injury in vivo by bacterial lipopolysaccharide, tumor necrosis factor, and IL-1.

1989 • 167 citations

Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo.

1981 • 166 citations

Avian immunology : basis and practice

1987 • 166 citations

Structure-function relationships for the IL 2-receptor system. IV. Analysis of the sequence and ligand-binding properties of soluble Tac protein.

1987 • 165 citations

T-cell interactions in autoimmunity

1988 • 163 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus.

1988 • 162 citations

An analysis of the cellular requirements for the production of soluble interleukin-2 receptorsin vitro

1986 • 161 citations

Accessory Cell Signals Involved in T‐Cell Activation

1990 • 160 citations

Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus

1984 • 159 citations

IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death.

1989 • 158 citations

Treatment with gamma-interferon triggers the onset of collagen arthritis in mice

1988 • 158 citations

Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.

1989 • 156 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

Long-term observations of autoimmune-prone mice treated for autoimmune disease by allogeneic bone marrow transplantation.

1989 • 154 citations

IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells.

1990 • 154 citations

Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor.

1989 • 154 citations

Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat.

1983 • 152 citations

Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis

1990 • 149 citations

Tumor necrosis factor in the serum of patients with systemic lupus erythematosus

1989 • 149 citations

An Acquired Chemotactic Defect in Neutrophils from Patients Receiving Interleukin-2 Immunotherapy

1990 • 149 citations

Mechanism of Interleukin-2 Signaling: Mediation of Different Outcomes by a Single Receptor and Transduction Pathway

1989 • 148 citations

Treatment of corticosteroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10) [see comments]

1990 • 148 citations

The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.

1987 • 146 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

Severe Combined Immunodeficiency Due to a Specific Defect in the Production of Interleukin-2

1990 • 146 citations

Neonatal Thymectomy Results in a Repertoire Enriched in T Cells Deleted in Adult Thymus

1989 • 146 citations

Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis.

1988 • 141 citations

Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines.

1988 • 141 citations

Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus

1990 • 140 citations

Delineation of the mechanism of inhibition of human T cell activation by PGE2.

1990 • 140 citations

PREVENTION OF REJECTION OF KIDNEY TRANSPLANTS BY MONOCLONAL ANTIBODY DIRECTED AGAINST INTERLEUKIN 2

1987 • 139 citations

T cell activation in Guillain‐Barré syndrome and in MS

1990 • 137 citations

Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C

1988 • 137 citations

Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol.

1990 • 136 citations

In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration.

1987 • 134 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

Interleukin-2 in Scleroderma: Correlation of Serum Level with Extent of Skin Involvement and Disease Duration

1989 • 134 citations

Plasma interleukin 2 receptor levels in renal allograft recipients

1987 • 132 citations

Molecular Genetics of Murine Lupus Models

1989 • 129 citations

Acquired Defect in Interleukin-2 Production in Patients with Type I Diabetes Mellitus

1986 • 129 citations

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice.

1981 • 128 citations

Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.

1989 • 127 citations

Elevated Concentrations of Soluble Interleukin-2 Receptors in Serum Samples and Bronchoalveolar Lavage Fluids in Active Sarcoidosis

1988 • 127 citations

Treatment of experimental disseminated Mycobacterium avium complex infection in mice with recombinant IL-2 and tumor necrosis factor.

1989 • 125 citations

Modification of T-cell proliferation and interleukin 2 production in mice infected with Trypanosoma cruzi.

1983 • 125 citations

Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors

1987 • 124 citations

Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning

1989 • 122 citations

In vivo induction of gamma interferon and tumor necrosis factor by interleukin-2 infusion following intensive chemotherapy or autologous marrow transplantation

1989 • 122 citations

Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases

1989 • 121 citations

Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease.

1990 • 120 citations

TRANSFER FACTOR IN HODGKIN'S DISEASE

1975 • 119 citations

Cyclosporine-induced autoimmunity. Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats.

1986 • 118 citations

The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation.

1988 • 118 citations

Tolerance in Transgenic Mice Expressing Major Histocompatibility Molecules Extrathymically on Pancreatic Cells

1990 • 117 citations

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

1989 • 117 citations

Elevated soluble interleukin‐2 receptor levels in the sera and synovial fluids of patients with rheumatoid arthritis

1988 • 114 citations

Presence of preactivated T cells in hemodialyzed patients: their possible role in altered immunity.

1986 • 114 citations

The role of interleukin-2 (IL-2) in the differentiatin of cytotoxic T cells: the effect of monoclonal anti-IL-2 antibody and absorption with IL-2 dependent T cell lines.

1981 • 113 citations

Decreased Synthesis of Interleukin-2 (IL-2) in Insulin-dependent Diabetes Mellitus

1984 • 113 citations

CS-A therapy in MRL-lpr/lpr mice: amelioration of immunopathology despite autoantibody production.

1987 • 113 citations

Characterization of T lymphocyte subpopulations responsible for deficient interleukin 2 activity in patients with systemic lupus erythematosus.

1985 • 112 citations

Association of lpr gene with graft-vs.-host disease-like syndrome.

1985 • 112 citations

Hematologic and immunologic effects of the systemic administration of recombinant interleukin-2 after autologous bone marrow transplantation

1990 • 112 citations

Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes

1987 • 112 citations

An autoimmune aetiology for hypothyroidism following interferon therapy for breast cancer

1988 • 111 citations

The interleukin 2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells.

1986 • 111 citations

Expression and role of p75 interleukin 2 receptor on human monocytes.

1990 • 111 citations

Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection.

1990 • 110 citations

Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones.

1990 • 109 citations

Soluble interleukin‐2 receptors in patients with systemic sclerosis

1990 • 108 citations

IL-2, a lectin with specificity for high mannose glycopeptides.

1989 • 107 citations

A comparison of PGE2 effects on human suppressor cell function and on interleukin 2 function.

1982 • 107 citations

The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2.

1989 • 107 citations

Immunologic effects of interleukin 2 in primary immunodeficiency diseases

1983 • 107 citations

lnterleukin-2-dependent autocrine proliferation in T-cell development

1989 • 107 citations

The Obese Strain of Chickens: An Animal Model with Spontaneous Autoimmune Thyroiditis

1989 • 106 citations

Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis.

1984 • 106 citations

Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2.

1990 • 103 citations

Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells.

1986 • 102 citations

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

1989 • 100 citations

Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis.

1989 • 100 citations

Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor.

1988 • 99 citations

T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas.

1990 • 98 citations

Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75.

1990 • 98 citations

In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment.

1990 • 98 citations

Defective interleukin 2 production in patients after bone marrow transplantation and in vitro restoration of defective T lymphocyte proliferation by highly purified interleukin 2

1984 • 97 citations

IL-2 protects against anti-CD3-induced cell death in human medullary thymocytes.

1990 • 96 citations

Novel T-Lymphocyte Population in Combined Immunodeficiency with Features of Graft-versus-Host Disease

1989 • 96 citations

Thymic Requirement for Clonal Deletion During T Cell Development

1989 • 95 citations

Immunization with antigen and interleukin 2 in vivo overcomes Ir gene low responsiveness.

1985 • 95 citations

Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.

1988 • 95 citations

IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse.

1988 • 94 citations

Induction of endogenous cytokine-mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients.

1989 • 93 citations

Gene transfer via somatic hybridization in plants

1991 • 93 citations

Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus.

1988 • 92 citations

Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells.

1985 • 92 citations

In vitro study of mediators of inflammation in multiple sclerosis

1989 • 91 citations

T-cell function and specificity in athymic mice

1983 • 90 citations

Impairment of T cell activation in burn patients: a possible mechanism of thermal injury-induced immunosuppression.

1986 • 90 citations

Effects of recombinant murine tumor necrosis factor-alpha on immune function.

1990 • 89 citations

The role of interleukin 2 in autoimmunity

1989 • 89 citations

Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

1988 • 89 citations

The Interleukin‐2 Receptor, its Physiology and a New Approach to a Selective Immunosuppressive Therapy by Anti‐Interleukin‐2 Receptor Monoclonal Antibodies

1986 • 88 citations

Activation of the complement system during immunotherapy with recombinant IL-2. Relation to the development of side effects.

1990 • 87 citations

Significance of Self‐Recognition and Interleukin‐2 for Immunoregulation, Autoimmunity and Cancer

1982 • 87 citations

Self-tolerance to transgenic γδ T cells by intrathymic inactivation

1990 • 87 citations

Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis.

1984 • 86 citations

Passive immunization against tumor necrosis factor partially abrogates interleukin 2 toxicity.

1989 • 85 citations

Lymphokine gene expression in vivo is inhibited by cyclosporin A.

1990 • 85 citations

The Systemic Capillary Leak Syndrome: Appearance of Interleukin-2-Receptor-Positive Cells during Attacks

1990 • 84 citations

Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis.

1988 • 82 citations

T cell antigen receptor expression in athymic (nu/nu) mice. Evidence for an oligoclonal beta chain repertoire.

1987 • 81 citations

Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor

1990 • 81 citations

Role of IL-5 in IL-2-induced eosinophilia. In vivo and in vitro expression of IL-5 mRNA by IL-2.

1990 • 80 citations

Interleultin‐2 treatment‐associated eosinophilia is mediated by interleultin‐5 production

1990 • 80 citations

trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene.

1989 • 80 citations

Soluble IL-2 receptor levels in serum from blood donors seropositive for HIV.

1988 • 79 citations

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1988 • 79 citations

Inhibition of type 1 diabetes in BB rats with recombinant human tumor necrosis factor-alpha.

1990 • 78 citations

CD4⁺CD8⁺ thymocytes are susceptible to DNA fragmentation induced by phorbol ester, calcium ionophore and anti‐CD3 antibody

1990 • 78 citations

Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells.

1990 • 78 citations

The kinetics of immature murine thymocyte development in vivo

1990 • 77 citations

cDNA cloning and characterization of interleukin 2-induced genes in a cloned T helper lymphocyte.

1990 • 77 citations

T lymphocyte activation: a biological model of signal transduction.

1990 • 76 citations

Failure of T Cell Receptor V _β Negative Selection in an Athymic Environment

1989 • 76 citations

Immunologic effects of interleukin 2 in primary immunodeficiency diseases.

1983 • 75 citations

Multichain Interleukin-2 Receptor: A Target for Immunotherapy in Lymphoma

1989 • 75 citations

Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages.

1984 • 73 citations

Thyroiditis after treatment with interleukin-2 and interferon α-2a

1990 • 72 citations

Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.

1985 • 72 citations

Response to and production of interleukin 2 by peripheral blood and cerebrospinal fluid lymphocytes of patients with multiple sclerosis.

1984 • 71 citations

Interleukin-2 Initiates Metabolic Responses Associated with Critical Illness in Humans

1988 • 70 citations

Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody.

1988 • 70 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease

1990 • 70 citations

Activation of peripheral blood T cells via the p75 interleukin 2 receptor.

1989 • 70 citations

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.

1989 • 70 citations

Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice.

1988 • 70 citations

The effect of tumor necrosis factor α and γ‐interferon on the resorption of human articular cartilage and on the production of prostaglandin e and of caseinase activity by human articular chondrocytes

1989 • 69 citations

A secreted form of the human interleukin 2 receptor encoded by an "anchor minus" cDNA.

1986 • 69 citations

Spontaneous Diabetes Mellitus in the BB/W Rat: Effects of Glucocorticoids, Cyclosporin-A, and Antiserum to Rat Lymphocytes

1983 • 68 citations

Toxicity of human recombinant interleukin-2 in rats. Pathologic changes are characterized by marked lymphocytic and eosinophilic proliferation and multisystem involvement.

1989 • 68 citations

The purification and properties of human T cell growth factor.

1982 • 68 citations

Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor.

1990 • 68 citations

Is immunological tolerance (non-responsiveness) a consequence of interleukin 2 deficit during the recognition of antigen?

1984 • 67 citations

IMMUNE MECHANISMS IN CYCLOSPORINE-INDUCED SYNGENEIC GRAFT-VERSUS-HOST DISEASE

1989 • 67 citations

Evidence for additional subunits associated to the mouse interleukin 2 receptor p55/p75 complex.

1990 • 66 citations

IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor.

1989 • 65 citations

Partial agonist/antagonist mouse interleukin-2 proteins indicate that a third component of the receptor complex functions in signal transduction.

1990 • 64 citations

An associated molecule, p64, eith high-affinity interleukin 2 receptor

1990 • 64 citations

Impaired expression of high affinity interleukin 2 receptor on activated lymphocytes from patients with systemic lupus erythematosus.

1987 • 63 citations

Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus.

1989 • 63 citations

Deficient interleukin 2 production in rheumatoid arthritis: association with active disease and systemic complications.

1988 • 63 citations

Production of interleukin 2 (IL 2) by salivary gland lymphocytes in Sjögren's syndrome. Detection of reactive cells by using antibody directed to synthetic peptides of IL 2.

1985 • 63 citations

A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain.

1990 • 62 citations

Identification of IL 2R+ T cells and macrophages within rejecting rat cardiac allografts, and comparison of the effects of treatment with anti-IL 2R monoclonal antibody or cyclosporin.

1987 • 61 citations

Control of IL-2 receptor-alpha expression by IL-1, tumor necrosis factor, and IL-2. Complex regulation via elements in the 5' flanking region.

1990 • 61 citations

Altered expression of self-reactive T cell receptor V beta regions in autoimmune mice.

1990 • 60 citations

Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.

1989 • 60 citations

In vitro correction of the interleukin 2 defect of autoimmune mice

1983 • 60 citations

Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody.

1987 • 60 citations

Aberrant regulation of IL-1 expression in macrophages from young autoimmune-prone mice.

1990 • 59 citations

Expansion of cyclophosphamide-resistant cytotoxic precursors in vitro and in vivo by purified human interleukin 2.

1983 • 59 citations

Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor α-chain-like molecule on pituitary cells

1989 • 58 citations

Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation.

1990 • 58 citations

Spontaneous Thyroiditis in the Obese Strain of Chickens

1970 • 58 citations

Curing BB rats of freshly manifested diabetes by short‐term treatment with a combination of a monoclonal anti‐interleukin 2 receptor antibody and a subtherapeutic dose of cyclosporin A

1987 • 57 citations

Inhibition of pregnancy viability in mice following IL-2 administration.

1989 • 57 citations

Effect of cyclosporin A on spontaneous autoimmune thyroiditis of Obese strain (OS) chickens

1982 • 56 citations

Multiple sclerosis

1986 • 55 citations

Selective immunosuppression of activated T cells with the chimeric toxin IL-2-PE40. Inhibition of experimental autoimmune uveoretinitis.

1989 • 54 citations

Serial levels of soluble interleukin 2 receptor in the peripheral blood of patients with rheumatoid arthritis: correlations with disease activity.

1990 • 54 citations

Interleukin secretion by B cell lines and splenic B cells stimulated with calcium ionophore and phorbol ester.

1987 • 54 citations

A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.

1990 • 53 citations

Inhibitor of interleukin‐2 in rheumatoid synovial fluid

1987 • 53 citations

Interleukin‐1α, interleukin‐2, and soluble interleukin‐2 receptors in polymyositis

1990 • 53 citations

A case of fatalPemphigus Vulgaris in association with beta interferon and interleukin-2 therapy

1989 • 52 citations

Reversal by interferon‐γ of inhibition of delay ed‐type hypersensitivity induction by anti‐CD4 or antiinterleukin 2 receptor (CD25) monoclonal antibodies. Evidence for the physiological role of the CD4⁺ T_H1⁺ subset in mice

1988 • 52 citations

Severe myocarditis following high-dose interleukin-2 administration.

1989 • 52 citations

Antigen-reactive cloned helper T cells. II. Exposure of murine cloned helper T cells to IL 2-containing supernatant induces unresponsiveness to antigenic restimulation and inhibits lymphokine production after antigenic stimulation.

1984 • 51 citations

Enhanced production of interleukin‐2 in patients with progressive systemic sclerosis. hyperactivity of cd4‐positive t cells?

1988 • 51 citations

Analysis of lymphocytes infiltrating the thyroid gland of Obese strain chickens.

1985 • 51 citations

Thymic stromal cell clone with nursing activity supports the growth and differentiation of murine CD4+8+ thymocytes in vitro.

1990 • 50 citations

Intrathymic selection of murine TCRαβ⁺CD4⁻CD8⁻ thymocytes

1990 • 50 citations

Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in rats.

1989 • 50 citations

Increased production of interleukin-2 and IL-2 receptor in primary IgA nephropathy

1989 • 49 citations

Failure of infiltrating precursor cytotoxic T cells to acquire direct cytotoxic function in immunologically privileged sites.

1990 • 48 citations

Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice.

1989 • 48 citations

Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus

1984 • 47 citations

HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.

1990 • 47 citations

Elevated titers of cell-free interleukin 2 receptor in serum of lupus mice.

1987 • 47 citations

Evidence for enhanced interleukin 2 (IL-2) secretion and IL-2 receptor presentation by synovial fluid lymphocytes in rheumatoid arthritis.

1986 • 47 citations

Acquired Cyclic Amegakaryocytic Thrombocytopenia Associated with an Immunoglobulin Blocking the Action of Granulocyte–Macrophage Colony-Stimulating Factor

1989 • 47 citations

Viral inhibition of lymphocyte mitogenesis: interference with the synthesis of functionally active T cell growth factor (TCGF) activity and reversal of inhibition by the addition of same.

1983 • 46 citations

Myocarditis or acute myocardial infarction associated with interleukin-2 therapy for cancer

1990 • 45 citations

Expression of interleukin 2 receptors by monocytes from patients with acquired immunodeficiency syndrome and induction of monocyte interleukin 2 receptors by human immunodeficiency virus in vitro.

1990 • 45 citations

Effects of the deregulated expression of human interleukin-2 in transgenic mice

1989 • 45 citations

Role of interleukin 1 and interleukin 2 in rat and mouse arthritis models.

1986 • 44 citations

Involvement of the interleukin 2 pathway in the rearrangement and expression of both alpha/beta and gamma/delta T cell receptor genes in human T cell precursors.

1988 • 44 citations

Autoreactive T cells in MRL/Mpr-lpr/lpr mice. Characterization of the lymphokines produced and analysis of antigen-presenting cells required.

1988 • 43 citations

Analysis of CD3 and antigen receptor expression on T cell subpopulations of aged athymic mice

1988 • 43 citations

Natural suppressor activity in graft-vs-host spleen and normal bone marrow is augmented by IL 2 and interferon-gamma.

1986 • 42 citations

Regulation of interleukin 2 receptors on T cells from multiple sclerosis patients.

1986 • 42 citations

Development of fetal thymocytes in organ cultures. Effect of interleukin 2.

1987 • 42 citations

Impaired T-cell activation in patients with systemic lupus erythematosus

1989 • 42 citations

Characterization of V_β‐bearing cells in athymic (nu/nu) mice suggests an extrathymic pathway for T cell differentiation

1990 • 41 citations

MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice.

1989 • 39 citations

Recent advances in the understanding of humoral and cellular mechanisms implicated in thyroid autoimmune disorders

1989 • 39 citations

Cytotoxicity of tumor necrosis factor for thyroid epithelial cells and its regulation by interferon‐γ

1987 • 39 citations

Antigen‐specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways

1987 • 38 citations

Role of α chain - IL-2 complex in the formation of the ternary complex of IL-2 and high-affinity IL-2 receptor

1990 • 38 citations

Selective inhibition of interleukin 2 gene function following thymocyte antigen/major histocompatibility complex receptor crosslinking: possible thymic selection mechanism.

1987 • 38 citations

Helper-independent CD8+ cytotoxic T lymphocytes express IL-1 receptors and require IL-1 for secretion of IL-2.

1989 • 38 citations

Recombinant interleukin 2 enhances spontaneous insulin‐dependent diabetes in BB rats

1986 • 38 citations

Thymic stroma is required for the development of human T cell lineages in vitro

1989 • 38 citations

Prolongation of murine skin allograft survival by immunologic manipulation with anti-interleukin 2 receptor antibody.

1986 • 38 citations

Interleukin-2-dependent control of disease development in spontaneously diabetic BB rats.

1990 • 37 citations

Defective T cell responsiveness in chronic lymphocytic leukemia: analysis of activation events

1986 • 37 citations

Genetic analysis of the imperfect association of H-2 haplotype with lupus-like autoimmune disease.

1989 • 37 citations

Decreased TcR‐CD3⁺ T cell numbers in healthy aged humans. Evidence that T cell defects are masked by a reciprocal increase of TcR‐CD3⁻CD2⁺ natural killer cells

1988 • 37 citations

Administration of Recombinant Interleukin-2 Reduces the Local Parasite Load of Patients with Disseminated Cutaneous Leishmaniasis

1990 • 37 citations

Interleukin 2 inhibits in vitro growth of human T cell lines carrying retrovirus.

1985 • 37 citations

Suppression and augmentation of rat adjuvant arthritis with monoclonal anti-interferon-gamma antibody.

1989 • 36 citations

Inducibility of interleukin-2 RNA expression in individual mature and immature T lymphocytes.

1987 • 35 citations

Production of Tumor Necrosis Factor/Cachectin by Peripheral Blood Mononuclear Cells in Patients with Systemic Lupus erythematosus

1989 • 34 citations

“In vivo” activated splenic T cells are refractory to interleukin 2 growth “in vitro”

1987 • 34 citations

Mutual cell interactions and the selection of immune repertoires

1988 • 34 citations

Interleukin-2 production and interleukin-2 receptor expression in children with newly diagnosed diabetes

1988 • 33 citations

Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3: role of interleukin-1

1990 • 33 citations

Evidence of enhanced recombinant interleukin-2 sensitivity in thymic lymphocytes from patients with myasthenia gravis: possible role in autoimmune pathogenesis

1989 • 32 citations

Immune abnormalities associated with HLA-B8: Lymphocyte subsets and functional correlates

1986 • 32 citations

Influence of activating stimulus on functional phenotype: interleukin 2 mRNA accumulation differentially induced by ionophore and receptor ligands in subsets of murine T cells.

1988 • 32 citations

A role for interleukin 4 in the differentiation of mature T cell receptor gamma/delta + cells from human intrathymic T cell precursors.

1990 • 31 citations

Decreased interleukin 2 inhibitor in sera of patients with autoimmune disorders.

1986 • 31 citations

Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3 in clinically healthy individuals.

1989 • 31 citations

Multiple cytokine activities and loss of interleukin 2 inhibitor in synovial fluids of patients with rheumatoid arthritis.

1988 • 31 citations

Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice. L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity.

1988 • 31 citations

Immunogenetic analysis of spontaneous autoimmune thyroiditis of obese strain chickens

1989 • 30 citations

Are the IL-2 Receptors Expressed in the Murine Fetal Thymus Functional?

1989 • 30 citations

Regulation of expression of T cell γ chain, L3T4 and Ly-2 messages in Abelson/moloney virus-transformed T cell lines

1988 • 30 citations

Changes in inducibility of IL-2 receptor alpha-chain and T cell-receptor expression during thymocyte differentiation in the mouse.

1989 • 29 citations

Distinct Reactivities of Four Monoclonal Antibodies with Human Interleukin 2 Receptor

1985 • 29 citations

Soluble interleukin 2 receptors are released by long term-cultured insulin-specific T cells transiently after contact with antigen.

1987 • 29 citations

Interleukin 2 activity in chronic liver disease and the effect of in vitro alpha-interferon.

1986 • 29 citations

The regulatory effects of cytokines on the induction of a peripheral immunologic tolerance in mice.

1990 • 28 citations

Deficient phytohemagglutinin‐induced interleukin‐2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate

1988 • 28 citations

Interleukin-1 and interleukin-2 production by peripheral blood mononuclear cells in multiple sclerosis patients

1988 • 28 citations

Familial Occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus

1989 • 28 citations

Defective IL2 production in active rheumatoid arthritis. Regulation by radiosensitive suppressor cells.

1986 • 28 citations

T cells from autoimmune "IL 2-defective" MRL-lpr/lpr mice continue to grow in vitro and produce IL 2 constitutively.

1984 • 27 citations

Human interleukin 2 (IL 2) receptor β chain allows transduction of IL 2-induced proliferation signal(s) in a murine cell line

1989 • 27 citations

Tolerance in vivo and in vitro

1990 • 27 citations

Importance of disulfide linkage for constructing the biologically active human interleukin-2

1987 • 27 citations

Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes

1983 • 27 citations

Reconstitution of a functional IL-2 receptor by the beta-chain cDNA. A newly acquired receptor transduces negative signal.

1989 • 26 citations

DEVELOPMENT OF SUPPRESSOR LYMPHOCYTES DURING ACUTE REJECTION OF RAT CARDIAC ALLOGRAFTS AND PRESERVATION OF SUPPRESSION BY ANTI-IL-2-RECEPTOR MONOCLONAL ANTIBODY

1986 • 26 citations

IL-2 receptor subunit, p75: direct demonstration of its IL-2 binding ability by using a novel monoclonal antibody

1989 • 26 citations

Interleukin-2 Protects Neonatal Mice from Lethal Herpes Simplex Virus Infection: A Macrophage-Mediated, Interferon-Induced Mechanism

1989 • 26 citations

In vitro T cell hyperreactivity in Obese strain (OS) chickens is due to a defect in nonspecific suppressor mechanism(s).

1985 • 26 citations

Therapy for systemic juvenile rheumatoid arthritis with γ‐interferon: A pilot study of nine patients

1989 • 26 citations

Interleukin 2 defect in the peripheral blood and the lung in patients with Sjögren's syndrome.

1986 • 26 citations

Molecular Indices of Functional Competence in Developing T Cells

1988 • 26 citations

Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus

1989 • 26 citations

Suppression of P2- T cell line-mediated experimental autoimmune neuritis by interleukin-2 receptor targeted monoclonal antibody ART 18

1989 • 25 citations

Defective interleukin-2 induction of lymphokine-activatedkiller (LAK) activity in peripheral blood T lymphocytesof patients with monoclonal gammopathies

1990 • 25 citations

Autoreactivity accelerates the development of autoimmunity and lymphoproliferation in MRL/Mp-lpr/lpr mice.

1987 • 24 citations

Interleukin 2 is a proliferative signal for B cells from autoimmune mice

1986 • 24 citations

Enumeration of cytokine‐secreting cells at the single‐cell level

1989 • 23 citations

Clonal anergy in self‐reactive α/β T cells is abrogated by heat‐shock protein‐reactive γ/δ T cells in aged athymic nude mice

1990 • 23 citations

Soluble interleukin 2 receptors in autoimmune chronic active hepatitis.

1990 • 23 citations

Eosinophilic myocarditis associated with high-dose interleukin-2 therapy

1990 • 23 citations

Altered Expression of Lymphocyte 11–2 Receptors in Burned Patients

1988 • 22 citations

5‐Azacytidine inhibits the lpr gene‐induced lymphadenopathy and acceleration of lupus‐like syndrome in MRL/MpJ‐lpr/lpr mice

1990 • 22 citations

Blocking of interleukin 2 (IL 2) binding to the IL 2 receptor is not required for the in vivo action of anti‐IL 2 receptor monoclonal antibody (mAb). I. The production, characterization and in vivo properties of a new mouse anti‐rat IL 2 receptor mAb that reacts with an epitope different to the one that binds to IL 2 and the mAb ART‐18

1987 • 21 citations

Soluble interleukin‐2 receptors in children with kawasaki syndrome

1990 • 21 citations

Cutaneous response to recombinant interleukin 2 in human immunodeficiency virus 1-seropositive individuals.

1990 • 21 citations

Systemic lupus erythematosus sera antilymphocyte reactivity: detection of antibodies to Tac-antigen positive T cell lines.

1986 • 21 citations

Modification of Emerging Repertoires by Immunosuppression in Immunodeficient Mice Results in Autoimmunity

1986 • 21 citations

The effects of interleukin 2 on early and late thymocyte differentitaion in foeatl thymus organ culture

1990 • 21 citations

Immunoregulation through CD8 (Ly‐2): state of aggregation with the α/β/CD3 T cell receptor controls interleukin 2‐dependent T cell growth

1989 • 20 citations

Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2.

1989 • 20 citations

Severe intrahepatic cholestasis in patients treated with recombinant interleukin-2 and lymphokine-activated killer cells

1989 • 20 citations

Effect of recombinant human interleukin-2 on the course of experimental chronic respiratory tract infection caused by Klebsiella pneumoniae in mice

1988 • 20 citations

Expansion of large granular lymphocytes in IL-2-driven 14-day-old fetal thymocytes in organ culture.

1990 • 19 citations

Adoptive immunotherapy with IL-2 results in the loss of delayed-type hypersensitivity responses and the development of immediate hypersensitivity to recall antigens

1989 • 19 citations

Interleukin 2 Activates BB/W Diabetic Rat Lymphoid Cells Cytotoxic to Islet Cells

1987 • 19 citations

IL-2 normalizes defective suppressor T cell function of patients with systemic lupus erythematosus in vitro.

1986 • 19 citations

Phenotypical characterization of the cells invading pancreatic islets of diabetic BB/OK rats: effect of interleukin 2 receptor‐targeted immunotherapy

1988 • 19 citations

Reactivation of rheumatoid arthritis during continuous infusion of interleukin 2: evidence of lymphocytic control of rheumatoid disease.

1990 • 18 citations

Suppression of the local graft‐vs.‐host reaction in ratsby treatment with a monoclonal antibody specific for the interleukin 2 receptor

1986 • 18 citations

Control of lymphokine expression in T helper 2 cells.

1989 • 18 citations

Generation of interleukin-2-dependent T cell lines from synovial fluids in rheumatoid arthritis.

1984 • 18 citations

Production of and response to interleukin-2 in Graves' disease

1988 • 18 citations

Measurement of cytokine release by human cells A quantitative analysis at the single cell level using the reverse haemolytic plaque assay

1990 • 18 citations

Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency.

1986 • 17 citations

In vivo and in vitro repertoire of CD3⁺CD4−CD8–thymocytes

1990 • 17 citations

Global or directed exocytosis?

1988 • 17 citations

Are Ly1 B cells responsible for the IL2-hyperresponsiveness of B cells in autoimmune-prone NZB × NZW F1 mice?

1989 • 17 citations

B cell hyperresponsiveness to interleukin 2 and the age-associated decline in murine lupus

1989 • 17 citations

Role of IL-2 in the generation of CD4+ suppressors of human B cell responsiveness.

1989 • 17 citations

Changes in laboratory results for cancer patients treated with interleukin-2

1990 • 16 citations

Quantitative studies on T-cell functions in mice

1984 • 16 citations

Insights into autoimmunity: from classical models to current perspectives.

1990 • 16 citations

Adoptive Immunotherapy of Diabetes in Autologous Nonobese Diabetic Mice With Lymphoid Cells Ex Vivo Exposed to Cyclosporin Plus Interleukin 2

1988 • 15 citations

Minireview serum inhibitors of interleukin-2

1988 • 15 citations

Two types of antibodies inhibiting interleukin‐2 production by normal lymphocytes in patients with systemic lupus erythematosus

1989 • 15 citations

Delineation of human thymocytes with or without functional potential by CD1-specific antibodies

1989 • 15 citations

GENETIC ANALYSIS OF EXTRATHYROIDAL FEATURES OF OBESE STRAIN (OS) CHICKENS WITH SPONTANEOUS AUTOIMMUNE THYROIDITIS

1988 • 14 citations

Expression of the p75 interleukin 2‐binding protein on CD34^‐8^‐Tac^‐ cells from autoimmune MRL/MP‐lpr/lpr mice

1989 • 14 citations

The phylogeny of interleukin-2

1985 • 14 citations

Low doses of interleukin 2 induce bystander cell lysis by antigen‐specific CD4 inflammatory T cell clones in short‐term assay

1988 • 14 citations

T lymphocyte subsets, suppressor and contrasuppressor cell functions, and production of interleukin-2 in the peripheral blood of rheumatic fever patients and their apparently healthy siblings

1990 • 14 citations

How Many Genes Code for Organ-Specific Autoimmunity?

1990 • 14 citations

Mechanisms of T cell hyperreactivity in obese strain (OS) chickens with spontaneous autoimmune thyroiditis: lack in nonspecific suppression is due to a primary adherent cell defect.

1987 • 14 citations

Suppression of concanavalin A-induced responses in splenic lymphocytes by activated macrophages in the non-obese diabetic mouse

1989 • 14 citations

EXOGENOUS RECOMBINANT INTERLEUKIN-2 ABROGATES ANTERIOR-CHAMBER-ASSOCIATED IMMUNE DEVIATION

1987 • 13 citations

Cytotoxic activity of interleukin-2 (IL-2) activated killer cells toward thyroid epithelial cells.

1989 • 13 citations

Interplay between IL-2 and IL-4 in human thymocyte differentiation: antagonism or agonism

1991 • 13 citations

IL-2 antibody production in lupus mice

1989 • 12 citations

Acalculus lymphoeosinophilic cholecystitis associated with interleukin-2 and lymphokine-activated killer cell therapy.

1990 • 12 citations

Monitoring of interleukin-2 receptor (IL-2R) expression in vivo and studies on an IL-2R-directed immunosuppressive therapy of active and adoptive adjuvant-induced arthritis in rats.

1988 • 12 citations

Deficits in T helper cells after total lymphoid irradiation (TLI): Reduced IL-2 secretion and normal IL-2 receptor expression in the mixed leukocyte reaction (MLR)

1990 • 12 citations

Lymphocyte infiltration into cerebellum in transgenic mice carrying human IL-2 gene

1989 • 12 citations

A novel role for interleukin 2 in antibody responses: down-regulation of T helper cell activation.

1987 • 11 citations

Interleukin-2 production in Brown-Norway rats with HgCl2-induced autoimmune disease: paradoxical in vivo versus in vitro findings.

1988 • 11 citations

Ontogeny of T cell development in avian scleroderma

1990 • 11 citations

Developmental regulation of serum interleukin-2 receptor concentrations: Attenuation of the childhood peak in patients at risk for developing or having recently developed type I diabetes mellitus

1989 • 11 citations

IL-2 production in the autologous mixed lymphocyte reaction of patients with juvenile rheumatoid arthritis.

1988 • 11 citations

Analysis of T-cell subpopulations in human IL-2Rα transgenic mice: Expansion of Thy1.2- thymocytes and depletion of double-positive T-cell precursors

1989 • 10 citations

Pretreatment of cloned helper T lymphocytes with IL-2 induces unresponsiveness to antigen and concanavalin A, associated with decreased inositol phosphate and diacylglycerol production.

1989 • 10 citations

Cellular aspects of myasthenia gravis

1988 • 10 citations

Interleukin 2 activates BB/W diabetic rat lymphoid cells cytotoxic to islet cells

1987 • 10 citations

Structure of the functional interleukin-2 receptor: Evidence for the association of human p55 and murine p75 molecules in a mouse T cell line

1989 • 10 citations

Reversible interleukin-2 response defects in systemic lupus erythematosus.

1989 • 9 citations

Synergistic induction by calcium ionophore and phorbol ester of interleukin-2 (IL-2) receptor expression, IL-2 production, and proliferation in autoimmune MRL/MP-lpr mice.

1986 • 9 citations

Deficient interleukin-2-activated killer cell cytotoxicity in patients with systemic lupus erythematosus

1989 • 8 citations

The evidence for the IL-2 recptor β Chain processing from p70 to p75

1990 • 8 citations

Suppression of T‐Cell Mediated Autoimmune Disease with Antibodies against the Interleukin‐2 Receptor Effect of Hybridoma ART‐18 on T Line Mediated Experimental Autoimmune Encephalomyelitis

1986 • 8 citations

Induction of anomalous killing activity from antigen-specific CTL clones by adding high doses of human recombinant interleukin 2

1988 • 8 citations

Adoptive immunotherapy of diabetes in autologous nonobese diabetic mice with lymphoid cells ex vivo exposed to cyclosporin plus interleukin 2

1988 • 8 citations

Lysis of Autologous Human Macrophages by Lymphokine-Activated Killer Cells: Interaction of Effector Cell and Target Cell Conjugates Analyzed by Scanning Electron Microscopy

1990 • 7 citations

CD4-targeted immune intervention: a strategy for the therapy of AIDS and autoimmune disease

1991 • 7 citations

Autoimmune T-lymphocytes with specificity for pancreatic islet antigens

1985 • 7 citations

Suppression of antigen-specific interleukin 2 production in the MRL/MpJ-lpr/lpr Mouse

1986 • 7 citations

IL-2 receptor expression in autoimmune MRL-lpr/lpr mice. The expanded L3T4-, Lyt-2- population does not express p75 and cannot generate functional high-affinity IL-2 receptors.

1989 • 7 citations

[Hypothyroidism after treatment with interleukin-2].

1989 • 7 citations

Interleukins and T-cell development

1990 • 7 citations

Mechanisms of cyclosporine protection against spontaneous diabetes mellitus in the BB/Wor rat

1989 • 6 citations

Lymphokines in Inflammation

1989 • 6 citations

Suppression of antigen-specific interleukin 2 production in the MRL/MpJ-lpr/lpr mouse.

1986 • 4 citations

Murine models of autoimmune diabetes: Nonspecific cytotoxic lymphocytes derived from pancreatic islets in the presence of IL-2

1989 • 3 citations

70–75 kd molecules expressed on LGL and T cells recognized by a mitogenic monoclonal antibody YTA-1; co-modulation and functional association with the interleukin 2 receptor p75

1990 • 3 citations

Deleted Work

1955 • 0 citations