Calcium-dependent, Interleukin 1β-converting Enzyme Inhibitor-insensitive Degradation of Lamin B1 and DNA Fragmentation in Isolated Thymocyte Nuclei

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease

1973 • 1,176 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Do all programmed cell deaths occur via apoptosis?

1993 • 545 citations

Calcium‐activated DNA fragmentation kills immature thymocytes

1989 • 533 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Programmed cell death in Caenorhabditis elegans

1994 • 379 citations

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase.

1994 • 345 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Calcium-activated DNA Fragmentation in Rat Liver Nuclei

1989 • 281 citations

Periodicity of DNA folding in higher order chromatin structures.

1990 • 275 citations

Oncogenes and cell death

1994 • 266 citations

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

1995 • 243 citations

Intracellular free calcium rise triggers nuclear envelope breakdown in the sea urchin embryo

1988 • 243 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes.

1992 • 225 citations

Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes.

1994 • 202 citations

Diffusion Across the Nuclear Envelope Inhibited by Depletion of the Nuclear Ca ²⁺ Store

1995 • 192 citations

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

1994 • 190 citations

Apoptosis by a cytosolic extract from Fas-activated cells.

1995 • 167 citations

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.

1996 • 164 citations

Endogenous nuclease. Properties and effects on transcribed genes in chromatin.

1982 • 159 citations

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

1991 • 157 citations

Translational control of InsP3-induced chromatin condensation during the early cell cycles of sea urchin embryos

1988 • 152 citations

Involvement of multiple proteases during Fas‐mediated apoptosis in T lymphocytes

1995 • 136 citations

Ubiquitin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis.

1993 • 124 citations

Mg(2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis.

1994 • 116 citations

The apoptosis endonuclease and its regulation.

1992 • 108 citations

An interleukin‐1β‐converting enzyme‐like protease is a common mediator of apoptosis in thymocytes

1995 • 101 citations

Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation.

1994 • 98 citations

Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation

1994 • 96 citations

Multiple Proteases Are Involved in Thymocyte Apoptosis

1995 • 82 citations

High molecular weight DNA fragmentation: a critical event in nucleoside analogue-induced apoptosis in leukemia cells.

1995 • 74 citations

Signalling and Chromatin Fragmentation in Thymocyte Apoptosis

1994 • 67 citations

T-Cell Tumor Elimination as a Result of T-Cell Receptor-Mediated Activation

1987 • 54 citations

A pre‐existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli

1995 • 53 citations

An inducible lymphocyte nuclear Ca2+/Mg(2+)-dependent endonuclease associated with apoptosis.

1996 • 50 citations

Ca(2+)-regulated serine protease associated with the nuclear scaffold.

1992 • 45 citations

Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2.

1995 • 36 citations

Predominance of the metastatic phenotype in somatic cell hybrids of the K-1735 murine melanoma.

1991 • 23 citations

Regulation of nuclear scaffold protease activity by calcium

1990 • 19 citations

An inhibitor of nuclear scaffold protease blocks chemical transformation of fibroblasts.

1993 • 11 citations

Induction of a novel Ca²⁺-dependent protease in preneoplastic and neoplastic liver tissues during rat liver carcinogenesis

1987 • 6 citations

Induction of a Novel Ca 2+-Dependent Chymotrypsin-Like Serine Protease by Tumor Promoters in Rat Livers<xref ref-type="fn" rid="FN1">2</xref>

1986 • 6 citations