Cell acidification in apoptosis

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

POLYAMINES

1984 • 2,996 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

The biochemistry of programmed cell death

1995 • 997 citations

Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.

1976 • 913 citations

Ionic Mechanisms of Neuronal Excitation by Inhibitory GABA _A Receptors

1995 • 800 citations

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

1989 • 774 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein

1977 • 532 citations

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

1996 • 488 citations

Disassembly and Reassembly of the Yeast Vacuolar H+-ATPase in Vivo

1995 • 454 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.

1994 • 420 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

Regulation of Plasma Membrane V-ATPase Activity by Dissociation of Peripheral Subunits

1995 • 337 citations

Intracellular Alkalinization Suppresses Lovastatin-induced Apoptosis in HL-60 Cells through the Inactivation of a pH-dependent Endonuclease

1995 • 306 citations

The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites.

1994 • 305 citations

Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification.

1993 • 286 citations

Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.

1994 • 257 citations

Apoptosis induced by inhibition of intercellular contact.

1994 • 256 citations

Tissue Transglutaminase and Apoptosis: Sense and Antisense Transfection Studies with Human Neuroblastoma Cells

1994 • 253 citations

Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase.

1995 • 248 citations

The Metabolism of Sphingomyelin

1966 • 248 citations

Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification

1995 • 243 citations

Acid-induced death in neurons and glia

1991 • 241 citations

Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.

1996 • 233 citations

The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells.

1989 • 195 citations

Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells.

1994 • 183 citations

Transglutaminase: Mechanistic features of the active site as determined by kinetic and inhibitor studies

1966 • 181 citations

Endonuclease activation during apoptosis: The role of cytosolic Ca2+ and pH

1992 • 179 citations

Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis.

1996 • 172 citations

A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells.

1993 • 167 citations

Growth factor activation and “H(+)-sensing” of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation.

1994 • 166 citations

Inhibition of vacuolar H(+)-ATPase by disulfide bond formation between cysteine 254 and cysteine 532 in subunit A.

1994 • 156 citations

Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.

1993 • 141 citations

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein

1993 • 131 citations

Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions.

1990 • 119 citations

The growth factor-activatable Na+/H+ exchange system: a genetic approach

1985 • 119 citations

Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement.

1993 • 114 citations

Activation of vacuolar-type proton pumps by protein kinase C. Role in neutrophil pH regulation

1992 • 110 citations

Events in Apoptosis

1996 • 109 citations

N-methyl-D-aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons

1994 • 103 citations

Studies on Acid Deoxyribonuclease. II. Isolation and Characterization of Spleen-Acid Deoxyribonuclease^*

1964 • 100 citations

Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle

1993 • 96 citations

Product of the steel locus suppresses apoptosis in hemopoietic cells. Comparison with pathways activated by granulocyte macrophage colony-stimulating factor.

1994 • 90 citations

Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor.

1992 • 87 citations

Specific Inhibitors of Vacuolar Type H+-ATPases Induce Apoptotic Cell Death

1995 • 84 citations

Heat induces intracellular acidification in human A-431 cells: role of Na(+)-H+ exchange and metabolism

1990 • 75 citations

Apoptosis Induced by IL-2 Withdrawal Is Associated with an Intracellular Acidification

1995 • 72 citations

Properties of some nuclear nucleases of rat thymocytes and their changes in radiation‐induced apoptosis

1993 • 68 citations

Acid activation of immediate early genes in renal epithelial cells.

1994 • 67 citations

Interleukin-1 Increases Vacuolar-type H+-ATPase Activity in Murine Peritoneal Macrophages

1996 • 64 citations

Efflux of protons from acidic vesicles contributes to cytosolic acidification of hepatocytes during ATP depletion

1991 • 58 citations

The acid deoxyribonuclease of neutrophils: a possible participant in apoptosis-associated genome destruction

1995 • 53 citations

Modulation of calcium homeostasis in cultured rat aortic endothelial cells by intracellular acidification

1993 • 52 citations

The gene encoding vacuolar H+-ATPase subunit C is overexpressed in multidrug resistant HL60 cells

1992 • 44 citations

Transcriptional repression of band 3 and CAII in v-erbA transformed erythroblasts accounts for an important part of the leukaemic phenotype.

1992 • 44 citations

Regulation of intracellular pH in neuronal and glial tumour cells, studied by multinuclear NMR spectroscopy

1994 • 41 citations

Novel Cl--Dependent Intracellular pH Regulation in Murine MDR 1 Transfectants and Potential Implications

1994 • 39 citations

Transient acidosis induces delayed neurotoxicity in cultured hippocampal slices

1995 • 38 citations

³¹P NMR characterization of cellular metabolism during dexamethasone induced apoptosis in human leukemic cell lines

1994 • 37 citations

A computer-based servo system for controlling isotonic contractions of muscle

1993 • 37 citations

LAK Cell Mediated Apoptosis of Human Bladder Cancer Cells Involves a pH-Dependent Endonuclease System in the Cancer Cell: Possible Mechanism of BCG Therapy

1995 • 34 citations

Oxidant stress decreases Na+/H+ antiport activity in bovine pulmonary artery endothelial cells

1994 • 33 citations

High intracellular pH in CFPAC: A pancreas cell line from a patient with cystic fibrosis is lowered by retrovirus-mediated CFTR gene transfer

1991 • 33 citations

Protection against Apoptosis in Chicken Bursa Cells by Phorbol Ester in Vitro

1993 • 32 citations

Altered sulfate transport via anion exchange in CFPAC is corrected by retrovirus-mediated CFTR gene transfer

1992 • 31 citations

The pH kinetic studies of bovine brain hexokinase

1980 • 30 citations

Transforming growth factorβ1 increases the number of apoptotic bodies and decreases intracellular pH in isolated periportal and perivenular rat hepatocytes

1995 • 30 citations

Fas-mediated apoptosis and sphingomyelinase signal transduction: the role of ceramide as a second messenger for apoptosis.

1996 • 29 citations

Agents that activate protein kinase C rescue sheep ileal Peyer's patch B cells from apoptosis

1993 • 28 citations

Crossover plot study of glycolytic intermediates in the ischemic canine heart.

1982 • 28 citations

Hepatocellular Na+/H+ exchange is activated at transcriptional and posttranscriptional levels in rat biliary cirrhosis

1994 • 26 citations

Bafilomycin A1 Inhibits IL-1-Stimulated Proteoglycan Degradation by Chondrocytes Without Affecting Stromelysin Synthesis

1995 • 24 citations

Effect of ursodeoxycholic acid on intracellular pH in a bile duct epithelium-like cell line

1994 • 23 citations

Pyridine nucleotide redox potential modulates cystic fibrosis transmembrane conductance regulator Cl- conductance.

1994 • 23 citations

Effect of intracellular pH on cytosolic free [Ca2+] in human epidermoid A-431 cells

1991 • 22 citations

Reduced surface area in apoptotic rounding of human chang liver cells from serum deprivation

1994 • 19 citations

The action of v-src on gap junctional permeability is modulated by pH.

1990 • 19 citations

Phorbol ester treatment stimulates tyrosine phosphorylation of a sea urchin egg cortex protein.

1990 • 17 citations

Independent changes of intracellular calcium and pH in identified leech glial cells

1993 • 16 citations

Structure and Properties of the Coated Vesicle Proton Pump

1992 • 15 citations

Regulation of intracellular pH in crypt cells from rabbit distal colon

1994 • 11 citations

Biphasic changes in intracellular pH induced by thyrotropin-releasing hormone in pituitary cells.

1993 • 10 citations

Myocardial buffering capacity and high-energy phosphate utilization during hypothermic circulatory arrest and recovery in the newborn lamb in vivo

1994 • 9 citations

Regulation of Na+-H+ exchange in normal NIH-3T3 cells and in NIH-3T3 cells expressing the ras oncogene

1989 • 9 citations

Regulation of Fas-Mediated Apoptosis

1997 • 8 citations

Computer simulation of energy metabolism in acidotic cardiac ischemia

1982 • 7 citations

Lymphocyte Death, p53, and the Problem of the “Undead” Cell

1995 • 3 citations