Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM

1985 • 1,599 citations

Biogenesis of Mitochondria

1988 • 1,396 citations

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

1992 • 949 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

IMPORT OF PROTEINS INTO MITOCHONDRIA

1991 • 583 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Cell death by apoptosis and its protective role against disease

1992 • 439 citations

Apoptosis: The Molecular Basis of Cell Death

1991 • 425 citations

Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature.

1989 • 318 citations

Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1991 • 307 citations

Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines.

1983 • 240 citations

Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry

1991 • 226 citations

Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.

1992 • 169 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor

1989 • 148 citations

Immortalization of rodent embryo fibroblasts by SV40 Is maintained by the Å gene

1983 • 100 citations

Participation of the mitochondrial genome in the differentiation of neuroblastoma cells

1992 • 98 citations

A carbocyanine dye, DiOC6(3), acts as a mitochondrial probe in human neutrophils

1982 • 88 citations

Cell Lines Established by a Temperature-Sensitive Simian Virus 40 Large-T-Antigen Gene Are Growth Restricted at the Nonpermissive Temperature

1989 • 87 citations

Glucocorticoid action on rat thymic lymphocytes. Experiments utilizing adenosine to support cellular metabolism lead to a reassessment of catabolic hormone actions.

1976 • 71 citations

Mitochondrial DNA is not fragmented during apoptosis.

1992 • 66 citations

A fluorescence-microscopic and flow-cytometric study of HeLa cells with an experimentally induced respiratory deficiency

1992 • 47 citations

Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes

1992 • 36 citations

Mitochondrial maturation during neuronal differentiation in vivo and in vitro

1991 • 28 citations

Anti‐CD3‐induced cell death in T cell hybridomas: mitochondrial failure and DNA fragmentation are distinct events

1991 • 27 citations

Expression of the mammalian mitochondrial genome. Role for membrane potential in the production of mature translation products.

1990 • 27 citations

Mitochondrial dysfunction in yeast expressing the cytoplasmic male sterility T-urf13 gene from maize: analysis at the population and individual cell level

1993 • 23 citations

Apoptosis is antagonized by large T antigens in the pathway to immortalization by polyomaviruses.

1994 • 20 citations

SV40 induced cellular immortalization: phenotypic changes associated with the loss of proliferative capacity in a conditionally immortalized cell line.

1990 • 14 citations

A study of dependence of protein synthesis in mitochondria on the transmembrane potential

1977 • 8 citations

Effects on mitochondrial metabolism of CCA, one inducer of neuroblastoma differentiation

1986 • 7 citations

Transfer of immortality by transfection of genomic DNA from SV40 established cell lines into rat embryo fibroblasts

1990 • 7 citations